Publications by authors named "Akika Sato"
Article Synopsis
- Exosomes from SW480 colorectal cancer cells were found to be taken up by HepG2 liver cancer cells via a specific cellular process called dynamin-dependent endocytosis, and they localized to the lysosomes of these recipient cells.
- After uptake, these exosomes triggered the activation of a signaling pathway known as ERK1/2 phosphorylation in the HepG2 cells, indicating a quick response to the exosome treatment.
- The SW480-derived exosomes also increased the migration of HepG2 cells in a wound-healing experiment, and this migration could be inhibited by using a drug (U0126) that blocks the ERK1/2 pathway, highlighting the role of exosomes in enhancing cellular movement.
