Publications by authors named "Akika Kubota"
Hyperthermia is known to enhance the effects of radiotherapy and chemotherapy. We have previously shown that hyperthermia also enhances the effects of molecular targeted therapy, immune cell therapy, and immune checkpoint inhibitors (ICI). Here, we present the recent clinical data and research results that suggest the mechanism of enhancement.
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- A total of 3,164 patients with advanced cancer received dendritic cell therapy from July 2005 to March 2020, showing an overall effectiveness rate of 19.0% for those treated more than 3 times.
- Among 133 patients treated with a combination of immune checkpoint inhibitors and dendritic cell therapy during the study period, the effectiveness rate rose significantly to 54.1%.
- For 98 patients receiving dendritic cell therapy with neoantigens, the effectiveness rate was 38.7%, compared to 18.3% for those without neoantigens, indicating that combining both immune checkpoint inhibitors and neoantigens further improved the effectiveness to 60.7%.