Publications by authors named "Akihito Koseki"
Article Synopsis
- Primary central nervous system vasculitis (PCNSV) is a rare condition affecting the brain and spinal cord, presenting with varied symptoms and lacking specific biomarkers.
- A case of a 40-year-old Japanese male initially misdiagnosed with multiple sclerosis (MS) later revealed PCNSV after experiencing unusual symptoms and spontaneous resolution of some lesions.
- The diagnosis was confirmed through a biopsy showing vasculitis, and after treatment with methylprednisolone and oral prednisolone, the patient showed no relapses or new MRI lesions, highlighting the importance of considering PCNSV in similar cases.
Background: Human T-cell leukemia virus type 1 (HTLV-1) causes HTLV-1-associated myelopathy (HAM), adult T-cell leukemia/lymphoma (ATL), HTLV-1-associated uveitis, and pulmonary diseases. Although both HAM and ATL show proliferation of infected cells, their pathogeneses are quite different. In particular, the pathogenesis of HAM is characterized by hyperimmune responses to HTLV-1-infected cells.
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- The study focuses on HAM (HTLV-1-associated myelopathy), a neuroinflammatory disease that causes various neurological issues, to evaluate its impact on patients' health-related quality of life (HRQoL).
- Researchers analyzed data from 538 HAM patients using the Short Form-36 (SF-36) and the SF-6D to assess the effects of major symptoms like gait dysfunction and urinary issues on HRQoL.
- Results indicated that HAM patients had significantly lower HRQoL scores compared to the national average, with gait dysfunction notably impacting physical functioning, but no significant effect on mental health was found.