Weak magnetic vestibular stimulation decreases postural sway.

Background: Perceptible galvanic vestibular stimulation (GVS) causes nystagmus and postural sway deterioration. Conversely, imperceptible GVS improves postural stability, suggesting the presence of stochastic resonance.

Research Question: Similar to GVS, strong magnetic vestibular stimulation of 7 T induces nystagmus and increases body sway.

CYP11A1 silencing suppresses HMGCR expression via cholesterol accumulation and sensitizes CRPC cell line DU-145 to atorvastatin.

Statins, which are cholesterol synthesis inhibitors, are well-known therapeutics for dyslipidemia; however, some studies have anticipated their use as anticancer agents. However, epithelial cancer cells show strong resistance to statins through an increased expression of HMG-CoA reductase (HMGCR), an inhibitory target of statins. Castration-resistant prostate cancer (CRPC) cells synthesize androgens from cholesterol on their own.

Alterations in the omics profiles in mevalonate pathway-inhibited cancer cells.

Aims: Statins, cholesterol-lowering drugs, are potential therapeutic agents for inhibiting cancer proliferation. However, the mechanisms that mediate the effects of statins, the homeostatic responses of tumor cells to statin therapy, and the modes underlying the antitumor effects of statins remain unclear.

Main Methods: To uncover the effects of statins on cancer cells in vitro, we performed transcriptome and metabolome analyses on atorvastatin-treated statin-resistant and statin-sensitive lung cancer cells.

[Analysis of Characteristics of Eye Movement While Viewing Movies and Its Application].

In this article, we present the following: a background of visually induced motion sickness (VIMS), the goal of our study, and descriptions of three recent studies conducted by our group on the measurement and analysis of eye movement while viewing movies and the relationship of eye movement with VIMS. First, this study focuses on the relationship between eye movement and motion sickness susceptibility. We investigated the relationship between the motion sickness susceptibility and the frequency of optokinetic nystagmus (OKN) with peripheral viewing.

Chondroitin sulfate E downregulates N-cadherin and suppresses myotube formation.

Myogenesis, the formation of muscle fibers, is affected by certain glycoproteins, including chondroitin sulfate (CS), which are involved in various cellular processes. We aimed to investigate the mechanism underlying CS-E-induced suppression of myotube formation using the myoblast cell line C2C12. Differentiated cells treated with 0.

Estrogen modulates the skeletal muscle regeneration process and myotube morphogenesis: morphological analysis in mice with a low estrogen status.

The purpose of this study was to elucidate the functions of estrogen and two estrogen receptors (ERs; ERα and ERβ) in the myoregeneration process and morphogenesis. Cardiotoxin (CTX) was injected into the tibialis anterior (TA) muscles of ovariectomized (OVX) mice to induce muscle injury, and subsequent myoregeneration was morphologically assessed. The diameter of regenerated myotubes in OVX mice was significantly smaller than that in intact mice at all time points of measurement.

Atorvastatin preferentially inhibits the growth of high ZEB-expressing canine cancer cells.

The epithelial-to-mesenchymal transition (EMT) is fundamental in cancer progression and contributes to the acquisition of malignant properties. The statin class of cholesterol-lowering drugs exhibits pleiotropic anticancer effects in vitro and in vivo, and many epidemiologic studies have reported a correlation between statin use and reduced cancer mortality. We have shown previously that sensitivity to the anti-proliferative effect of statins varies among human cancer cells and statins are more effective against mesenchymal-like cells than epithelial-like ones in human cancers.

Concomitant attenuation of HMGCR expression and activity enhances the growth inhibitory effect of atorvastatin on TGF-β-treated epithelial cancer cells.

Epithelial-mesenchymal transition (EMT) in primary tumor cells is a key prerequisite for metastasis initiation. Statins, cholesterol-lowering drugs, can delay metastasis formation in vivo and attenuate the growth and proliferation of tumor cells in vitro. The latter effect is stronger in tumor cells with a mesenchymal-like phenotype than in those with an epithelial one.

[Effect of Reading a Book on a Tablet Computer on Cerebral Blood Flow in the Prefrontal Cortex].

Objectives: By measuring cerebral blood flow in the prefrontal cortex, we aimed to determine how reading a book on a tablet computer affects sleep.

Methods: Seven students (7 men age range, 21-32 years) participated in this study. In a controlled illuminance environment, the subjects read a novel in printed form or on a tablet computer from any distance.

[Change in the Fusion Limit by Insertion of a Middle Image Equally Dividing the Parallactic Angle of 3D Stereoscopic Images].

Objectives: The purpose of this study was to identify and clarify the requirements for 3D stereoscopic images that do not cause viewing discomfort to the human eye even when the protrusion distance is large.

Methods: A total of 140 healthy men and women aged 14 to 79 years participated in this study. We first measured the fusion limits in these participants using two 3D stereoscopic images.

[Effect of Viewing a Long Stereoscopic Film on Equilibrium Function and Autonomic Nervous System].

Objectives: Owing to the recent rapid advancements in image processing and three-dimensional (3-D) technologies, stereoscopic images can now be viewed on television as well as in theaters and on gaming consoles among others. However, with these advancements, there have also been reports on motion sickness and asthenopia induced by viewing stereoscopic films. Human equilibrium function deteriorates when viewing stereoscopic films, which may lead to motion sickness; however, the exact cause of such motion sickness remains unknown.

[Temporal Analysis of Body Sway during Reciprocator Motion Movie Viewing].

Objectives: We aimed to investigate the effect of stereoscopic viewing and the degree of awareness of motion sickness on posture by measuring body sway during motion movie viewing.

Methods: Nineteen students (12 men and 7 women; age range, 21-24 years) participated in this study. The movie, which showed several balls randomly positioned, was projected on a white wall 2 m in front of the subjects through a two-dimensional (2-D)/three-dimensional (3-D) convertible projector.

[Assessing the influence of reconstruction kernel in plaque imaging in computed tomography].

Plaque imaging using computed tomography (CT) is an important diagnostic method for predicting the risk of vascular events. However, the CT value variability of plaques, which depends on the scan parameters, remains a key challenge. The aim of this study was to evaluate the effect of reconstruction properties on the CT value, area, and shape reproducibility of plaques.

Study on improvement of signal detectability considering noise characteristics in medical X-ray images.

The purpose of this study is to develop method for improvement of low-contrast signal detectability of general X-ray images used for observing overviews, included noise reduction technique and signal amplification technique, that are difficult to detect in the observing overview. The proposal method consists signal amplification part and noise reduction part. The noise reduction part first identifies and mathematizes the characteristics of the noise attributed to the X-ray imaging system before the subject is imaged.

[Development of automatic navigation measuring system using template-matching software in image guided neurosurgery].

An image-guided neurosurgery and neuronavigation system based on magnetic resonance imaging has been used as an indispensable tool for resection of brain tumors. Therefore, accuracy of the neuronavigation system, provided by periodic quality assurance (QA), is essential for image-guided neurosurgery. Two types of accuracy index, fiducial registration error (FRE) and target registration error (TRE), have been used to evaluate navigation accuracy.

Evaluation of errors influencing accuracy in image-guided neurosurgery.

Neurosurgeons sometimes find it difficult to locate tumors precisely during microsurgery, particularly tumors located in the brain parenchyma because of the absence of boundaries in this region. Image-guided neurosurgical techniques conducted with the help of neuronavigation systems have been developed and have gained importance recently. Accuracy is vital during image-guided neurosurgery.