Publications by authors named "Akihiro Shinkai"
Article Synopsis
- Chronic inflammation is significant in proliferative diabetic retinopathy (PDR), with retinal glial cells undergoing biological changes, particularly regarding the phosphorylation of αB-crystallin (CRYAB) that affects its function and secretion.
- The study utilized human retinal Müller cells (MIO-M1) and assessed gene/protein expressions through techniques like real-time quantitative PCR and ELISA, while also examining cell apoptosis through specific assays.
- Findings revealed that IL-1β reduces CRYAB mRNA in MIO-M1 cells but not the protein, and phosphorylation of serine 59 (Ser59) of αB-crystallin occurs, indicating αB-crystallin has
Prcis: Decreasing aqueous outflow resistance at trabecular meshwork is the main mechanism of modified 360-degree suture trabeculotomy (ST), and the preoperative C-value, which shows aqueous outflow resistance, is likely to be useful for predicting intraocular pressure (IOP) reduction.
Purpose: To clarify the mechanism of IOP reduction and the preoperative prognostic predictor of modified 360-degree ST.
Materials And Methods: Forty-three eyes of 32 patients with glaucoma who underwent ST at Hokkaido University Hospital between April 2017 and February 2020 were enrolled.
Prcis: A Kaplan-Meier survival curve analysis showed no significant differences in success rates between uveitic glaucoma (UG) and primary open angle glaucoma (POAG) 120 months after modified 360-degree suture trabeculotomy, which was effective for both groups in the long term.
Purpose: The aim of this study was to examine the outcomes of modified 360-degree suture trabeculotomy in patients with UG as compared with those with POAG.
Patients And Methods: This was a retrospective, nonrandomized, and comparative case series study.
Purpose: Cerebrospinal fluid hypovolemia syndrome (CHS) is a rare clinical entity that can be caused by spontaneous cerebrospinal fluid (CSF) leakage. The aim of this study is to report a rare case of CHS after a traffic accident in a patient who presented with diplopia and ptosis with fluctuation and was initially diagnosed with ocular myasthenia gravis.
Observeations: A 29-year-old man exhibited fluctuating left ptosis and diplopia after a traffic accident.
Background: Cyclodialysis cleft is an uncommon finding due to blunt ocular trauma. A larger and more chronic cyclodialysis requires surgical repair. The aim of this study was to introduce a minimally invasive suturing technique for the lens-sparing repair of traumatic cyclodialysis cleft and evaluate outcomes.
View Article and Find Full Text PDFPurpose: To evaluate the long-term outcomes of trabeculectomy with mitomycin C (MMC-TLE) in patients with uveitic glaucoma (UG). This was a retrospective, nonrandomized case series study. MMC-TLE was performed on 50 eyes with UG between February 2001 and January 2015 at Hokkaido University Hospital.
View Article and Find Full Text PDFPurpose: To describe a rare case of cerebrospinal fluid hypovolemia syndrome after a traffic accident with abnormal eye movements.
Observations: A 19-year-old man was referred to our clinic after being hit by a car five months ago while riding a bicycle. After the accident, he sometimes noticed oscillopsia, and had postural headaches and reading difficulties.
Optical coherence tomography (OCT) is an imaging technique used to obtain three-dimensional information on the retina. In this article, we evaluated the structural neuro-retinal abnormalities, especially the thickness in the ganglion cell complex (GCC), in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). The GCC thickness in MELAS patients was significantly thinner than that in normal controls even when they had no history of transient homonymous hemianopia.
View Article and Find Full Text PDFMorphological features of macular telangiectasia type 2 in Japanese patients.
Graefes Arch Clin Exp Ophthalmol
May 2021
Article Synopsis
- The study researched the clinical progression of macular telangiectasia type 2 (MacTel-2) in 8 Japanese patients over an average follow-up of 42.8 months, measuring changes in visual acuity, macular thickness, and other ocular parameters.
- While the overall changes in best-corrected visual acuity and ellipsoid zone loss were not statistically significant, central macular thickness showed a meaningful increase compared to baseline measurements.
- A notable percentage of patients experienced improvements in macular findings, indicating that Japanese patients might have less severe clinical forms of MacTel-2 compared to Caucasian patients described in previous studies.
Background: The relationship between anti-estrogen drugs and macular telangiectasia type 2 (MacTel-2) remains unknown. Here we report a case with anti-estrogen maculopathy resembling MacTel-2 with improved visual function and macular morphology following cessation of anti-estrogen drugs.
Case Presentation: A 53-year-old woman presented with a 5-month history of central vision loss and anorthopia in both eyes.