CD69 Signaling in Eosinophils Induces IL-10 Production and Apoptosis via the Erk1/2 and JNK Pathways, Respectively.

Introduction: Eosinophils contribute to the pathogenesis of allergic diseases, including asthma, allergic rhinitis, and atopic dermatitis. We previously reported that human tissue eosinophils have high CD69 expression compared to blood eosinophils, and its expression is correlated with disease severity and the number of infiltrated eosinophils. However, biological CD69 signaling activity in eosinophils remains unclear.

Identification of Risk Factors for Mortality and Prolonged Hospitalization in Patients Treated With Surgical Drainage for Otogenic Intracranial Complications: A Nationwide Study Using a Japanese Inpatient Database.

Objective: Data on risk factors for otogenic intracranial complications including cerebral abscess have been limited. Using a nationwide database, the aim was to identify the factors related to mortality and delayed discharge.

Study Design: Retrospective.

Effect of the Alumina Particle Filler Structure and Particle Size on the Dielectric Constant and Dielectric Loss in the Millimeter-Wave Band.

The sixth-generation communication system (6G) is the next-generation communication system and is expected to be operational in 2030. The following areas will use 6G: the frequency band employed in 6G is expected to be 100 GHz or higher, necessitating additional reduction of the dielectric constant and dielectric loss in the substrate material. In this study, we examined the effects of compounding various phases of alumina with different shapes and crystal phases on the dielectric constant and dielectric loss of cyclo-olefin polymer (COP) compounds.

Omalizumab is effective for a patient with pollen-food allergy syndrome who experienced intractable lip edema.

Pollen-food allergy syndrome (PFAS) is an immunoglobulin E (IgE)-mediated allergic reaction caused when patients with pollen allergy ingest food having cross-reactivity with pollen. To date, no effective treatment method for this has been established. Here we report the case of a patient with PFAS who experienced lip edema, causing difficulties in treatment.

Long-term sublingual immunotherapy provides better effects for patients with Japanese cedar pollinosis.

Objective: Japanese cedar pollinosis is an endemic disease affecting a large proportion of Japan's population. Five seasons have passed since sublingual immunotherapy (SLIT) for Japanese cedar pollinosis was included in the public insurance coverage in Japan. In this study, we evaluated the clinical effects of long-term SLIT for Japanese cedar pollinosis on upper respiratory symptoms primarily represented by nasal symptoms and inflammation of the respiratory tract in the 2019 season, in which considerable amount of cedar pollen was dispersed.

Improving the thermal conductivity of epoxy composites using a combustion-synthesized aggregated β-SiN filler with randomly oriented grains.

Electrically insulating and thermally conductive polymer matrix composites are desirable for industry applications as they improve the reliability of high-performance electronic devices, particularly via heat dissipation in devices loaded with several electronic components. In this study, an aggregated β-SiN filler with randomly oriented grains was produced via combustion synthesis to improve the thermal conductivity of epoxy composites. The thermal conductivities of the prepared composites were investigated as a function of the filler content, and the values were compared to those of composites loaded with commercial β-SiN (non-aggregated) Negligible difference was observed in the thermal conductivities of both types of composites when the SiN content was below 40 vol%; however, above 40 vol%, the aggregated β-SiN filler-loaded composites showed higher thermal conductivities than the commercial β-SiN-loaded composites.

Anionic surfactant enhanced phosphate desorption from Mg/Al-layered double hydroxides by micelle formation.

Desorption of interlayer hydrogen phosphate (HPO4) from hydrogen phosphate intercalated Mg/Al-layered double hydroxide (LDH-HPO4) by anion exchange with surfactant anions has been investigated under controlled conditions. Three types of surfactant, Dodecylbenzenesulphonate (DBS), Dodecylsulphate (DS) and 1-Octanesulphonate (OS), anions were used for intercalation experiments over a range of concentrations, and for all solutions, it was shown that the desorption of hydrogen phosphate is enhanced at concentrations close to the critical micelle concentration (CMC). Intercalation of the surfactant anions into LDH-HPO4 was confirmed by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning electron microscopy (SEM).