Publications by authors named "Akihiro Kawai"
Article Synopsis
- * Results showed that the ERAS protocol significantly shortened hospital stays, improved bowel recovery, and reduced POI in non-frail patients, but it did not have the same benefits for frail patients.
- * The findings suggest that while ERAS is effective for non-frail patients, frail patients might require additional strategies, like prehabilitation, to better manage POI post-surgery.
Article Synopsis
- The study explores how using kidney donors after cardiac death (DCD) can address organ shortages and highlights the importance of understanding delayed graft function (DGF), which is a common issue in these transplants.* -
- Researchers analyzed plasma samples from patients who received kidneys from living donors (LD), brain-dead donors (BD), and DCD donors, finding that total cell-free DNA (tCF-DNA) levels were significantly higher in DCD and BD transplants compared to LD transplants.* -
- The study concludes that elevated tCF-DNA levels are associated with DGF and could serve as a predictive biomarker for kidney recovery after DCD transplantation.*
Article Synopsis
- An 82-year-old woman with a history of uterine prolapse developed a rare condition involving complete bladder eversion and presented with vulvar bleeding and a protruding uterus.
- Diagnosis was confirmed through pelvic examination and imaging, leading to the initial surgical treatment involving robotic techniques for bladder and uterine repair.
- Despite a recurrence of the condition 10 months later, subsequent surgeries successfully corrected the issue, with no further recurrences reported.
Background: The pool of brain-dead donors (BDDs) was increased with the revision to the relevant law in 2010, and islet transplantation from BDDs was started in 2013. The present study assessed the influence of using pancreases from BDDs on islet transplantation in Japan.
Methods: The donor information registered with the secretariat of islet transplants from 2012 was reviewed, and the results of 86 clinical islet isolations performed in Japan between 2003 and 2018 with non-heart-beating donors (NHBDs) ( = 71) and BDDs ( = 15) were investigated.
Objectives: The aim of this study was to compare the outcomes of pancreatic transplantation from pediatric donors younger than 15 years of age to the outcomes of pancreatic transplantation from adult donors.
Methods: Sixty patients underwent pancreatic transplantation in our facility from August 2012 to June 2019. These patients were divided into two groups according to the age of the donor: Cases in which the donor was younger than 15 years of age were classified into the PD group ( = 7), while those in which the donor was older than 15 years of age were classified into the AD group ( = 53).
Objectives: To evaluate the prognostic value of the warm ischemic time and the validity of the Kidney Donor Profile Index/Kidney Donor Risk Index for predicting the survival of donors after cardiac death grafts.
Methods: We retrospectively assessed 315 kidneys retrieved from donors after cardiac death at Fujita Health University Hospital, Toyoake, Aichi, Japan. The Kidney Donor Profile Index/Kidney Donor Risk Index was calculated and the grafts were enrolled.
Objectives: Contrast-enhanced ultrasonography can evaluate microcirculation. Thus, we used contrast-enhanced ultrasonography in evaluating pancreas graft perfusion and examined the relationship between graft circulation and function.
Methods: Contrast-enhanced ultrasonography was performed in 17 cases within 24 hours and at 1, 3, 5, 7, 14, 21, and 28 days after transplantation (Tx).
Background: Despite progress in the current genetic manipulation of donor pigs, most non-human primates were lost within a day of receiving porcine lung transplants. We previously reported that carbon monoxide (CO) treatment improved pulmonary function in an allogeneic lung transplant (LTx) model using miniature swine. In this study, we evaluated whether the perioperative treatment with low-dose inhalation of CO has beneficial effects on porcine lung xenografts in cynomolgus monkeys (cynos).
View Article and Find Full Text PDFBackground: Strategies that reduce ischemia-reperfusion injury (IRI) have the potential to expand the numbers of available organs for transplantation. Recent reports in rodent models have demonstrated that high-mobility group box 1 (HMGB1) acts as an alarm in initiating the inflammatory response resulting from ischemic injury. The aim of this study was to evaluate the cytoprotective effects of anti-HMGB1 antibodies on renal IRI in preclinical large animals.
View Article and Find Full Text PDFKidneys procured by donation after cardiac death (DCD) may increase the donor pool but are associated with high incidence of delayed graft function (DGF). Urinary liver-type fatty acid-binding protein (L-FABP) level is an early biomarker of renal injury after kidney transplantation (KTx); however, its utility is limited in DGF cases owing to urine sample unavailability. We examined whether serum L-FABP level predicts functional recovery of transplanted DCD kidneys.
View Article and Find Full Text PDFAlthough adult sycamore lace bugs Corythucha ciliata (Say) show no sign of aggregation, nymphs at all developing stages are gregarious. When an individual nymph in the center of a colony was squashed with a needlepoint, proximate nymphs showed evasive behavior. The same evasive reaction was produced by exposing aggregated nymphs to nymph hexane extract.
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