Publications by authors named "Akihiro Inoue"
Background: The EF-14 clinical trial demonstrated the safety and efficacy of tumor-treating fields (TTFields) for newly diagnosed glioblastoma. This study aimed to clarify the current status, safety, and efficacy of TTFields in Japanese patients who meet the EF-14 inclusion criteria.
Methods: This was a multicenter retrospective cohort study.
Article Synopsis
- * Patient symptoms included fever, headache, and hearing loss, with tests revealing infection indicators and abnormal brain lesions confirmed through advanced imaging techniques.
- * Rapid pathological diagnosis, including immunohistochemistry and PCR, played a vital role in distinguishing the cryptococcoma from a potential malignant tumor, leading to successful antifungal treatment.
Article Synopsis
- - The study focuses on improving the diagnosis of primary central nervous system lymphoma (PCNSL) during surgery by using intraoperative rapid immunohistochemistry (IHC), along with cytology and flow cytometry (FCM) for quicker and more accurate treatment decisions.
- - In a trial involving 35 patients from April 2020 to January 2024, the addition of cytology and FCM to rapid IHC significantly sped up the time from surgery to chemotherapy initiation for PCNSL (1.6 days versus 7.3 days), demonstrating the benefits of this combined approach.
- - Final pathological diagnoses confirmed the consistency of intraoperative rapid IHC results, and the combined method resulted in changes in treatment strategy in certain
Aim: The unique feature of Fontan circulation is elevated central venous pressure, which causes Fontan-associated liver disease (FALD). FALD is associated with a high incidence of hepatocellular carcinoma (HCC). Performing biopsies in patients with FALD is difficult as a result of warfarinization; gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI), a noninvasive examination, is useful for characterizing liver disease and detecting HCC.
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- A multicenter study by the Neurospinal Society of Japan examined treatment strategies for spinal cord astrocytomas (WHO grade II), aiming to determine the best methods and predictors for improved outcomes.
- Out of 1033 patients with spinal cord intramedullary tumors, 57 had diffuse astrocytoma; their treatment approaches included surgery alone, or combined with radiation or chemoradiotherapy, with outcomes analyzed based on treatment type and tumor proliferation rates.
- The findings indicated that surgery (with or without radiation) led to better survival rates compared to chemoradiotherapy, with a significant correlation between tumor resection extent and longer survival; an MIB-1 SI under 4.0%
Article Synopsis
- The study investigates treatment options and costs for malignant brain tumors (GBM and PCNSL) in Japan through a survey of 47 institutions.
- For GBM, the most common treatment is 'Surgery + radiotherapy with temozolomide', costing approximately 7.50 million JPY, with additional treatments raising costs significantly.
- PCNSL treatments, especially R-MPV therapy, also incur high costs, with some regimens exceeding 1 million JPY per month, highlighting the need for better cost-effectiveness assessments in future health studies.
An 87-year-old woman was hospitalized for liver abscesses and cholangitis due to common bile duct stones. She developed worsening anemia and abdominal pain. Contrast-enhanced computed tomography revealed an intrahepatic pseudoaneurysm and an arteriovenous fistula between the hepatic arteries and inferior vena cava.
View Article and Find Full Text PDFBackground: This study evaluated right ventricular (RV) volume, strain, and morphology using cardiac 4-dimensional computed tomography (4D-CT) to detect pulmonary hypertension (PH) in adults with repaired tetralogy of Fallot (TOF) scheduled for transcatheter pulmonary valve implantation (TPVI).
Methods And Results: Using cardiac 4D-CT data, we calculated RV strain in 3 different geometries and RV outflow tract (RVOT) mass in 42 patients with repaired TOF. We compared RV strain and RVOT mass between patients with and without PH.
Objectives: On F-Fludeoxyglucose (FDG) PET/CT, active sarcoid lesions are often difficult to differentiate from malignant lesions. We investigated the potential of the glucose metabolic rate (MR, mg/min/100 mL), a new quantification of glucose metabolic kinetics derived from direct reconstruction based on linear Patlak analysis, to distinguish between sarcoidosis and malignant lesions.
Materials And Methods: A total of 100 patients with cardiac sarcoidosis (CS) and 67 patients with cancer who underwent four-dimensional FDG PET/CT were enrolled.
Rationale And Objectives: This study investigated the use of deep learning-generated virtual positron emission tomography (PET)-like gated single-photon emission tomography (SPECT) for assessing myocardial strain, overcoming limitations of conventional SPECT.
Materials And Methods: SPECT-to-PET translation models for short-axis, horizontal, and vertical long-axis planes were trained using image pairs from the same patients in stress (720 image pairs from 18 patients) and resting states (920 image pairs from 23 patients). Patients without ejection-fraction changes during SPECT and PET were selected for training.
This study aims to elucidate the clinical and molecular characteristics, treatment outcomes and prognostic factors of patients with histone H3 K27-mutant diffuse midline glioma. We retrospectively analyzed 93 patients with diffuse midline glioma (47 thalamus, 24 brainstem, 12 spinal cord and 10 other midline locations) treated at 24 affiliated hospitals in the Kansai Molecular Diagnosis Network for CNS Tumors. Considering the term "midline" areas, which had been confused in previous reports, we classified four midline locations based on previous reports and anatomical findings.
View Article and Find Full Text PDFBackground: Alveolar rhabdomyosarcoma (ARMS) shows a predilection for the peripheral extremities and is very rarely identified as a primary in the brain. Here, we report a case of ARMS with multiple lesions exclusively within the central nervous system (CNS).
Case Description: A 20-year-old man presented to our hospital with a gradually increasing headache and disturbance of consciousness.
Background: Heart transplantation (HTx) is a definitive therapy for refractory heart failure. Cardiac allograft vasculopathy (CAV), characterized by diffuse arteriopathy involving the epicardial coronary arteries and microvasculature, is the major cause of death for patients with HTx. N-ammonia positron emission tomography (NH-PET) can offer diagnostic and prognostic utility for CAV.
View Article and Find Full Text PDFThis study aimed to evaluate the clinical usefulness of zero-echo time(ZTE)-based magnetic resonance imaging(MRI)in planning an optimal surgical approach and applying ZTE for anatomical guidance during transcranial surgery. P atients who underwent transcranial surgery and carotid endarterectomy and for whom ZTE-based MRI and magnetic resonance angiography(MRA)data were obtained, were analyzed by creating ZTE/MRA fusion images and 3D-ZTE-based MRI models. We examined whether these images and models could be substituted for computed tomography imaging during neurosurgical procedures.
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- Primary intramedullary spinal cord lymphoma (PISCL) is a rare condition that is challenging to diagnose early due to vague symptoms and imaging results, necessitating a biopsy for confirmation.
- A case study of a 70-year-old woman who exhibited symptoms like lower-limb paralysis and abnormal sensations revealed a spinal mass and high β2-microglobulin levels, pointing toward PISCL.
- The study emphasizes that in cases resistant to treatment, PISCL should be considered, and spinal cord biopsy should be performed if PET scans show increased FDG uptake and elevated β2-microglobulin in cerebrospinal fluid.
Article Synopsis
- The study aims to improve fluorescence-guided surgery for glioblastoma (GBM) by using berberine (BBR) to enhance 5-aminolevulinic acid (ALA) fluorescence, especially in glioma stem cells (GSCs) that typically don't fluoresce well.
- Methods included analyzing the effects of BBR on 5-ALA fluorescence through flow cytometry and examining its impact on the heme synthesis pathway's enzyme expression.
- Results showed that combining BBR with 5-ALA significantly increases fluorescence in GSCs, with BBR enhancing ALA synthetase 1 expression and showing promising results in animal studies, suggesting potential clinical applications.
Article Synopsis
- Glioblastoma (GBM) is highly invasive, making complete surgical removal difficult, which leads to inevitable tumor recurrence, often driven by glioma stem-like cells (GSCs) that resist treatments.
- The molecule CD44 plays a key role in this process by enhancing both tumor invasion and growth through various signaling pathways, particularly influenced by oxygen levels in the tumor environment.
- The hypoxic conditions around GBM change before and after surgery, with severe hypoxia promoting invasion via CD44 and moderate hypoxia encouraging tumor proliferation through HIF-2α, suggesting a critical link between oxygen levels and GBM recurrence.
Recurrent glioblastoma multiforme (GBM) is largely attributed to peritumoral infiltration of tumor cells. As higher CD44 expression in the tumor periphery correlates with higher risk of GBM invasion, the present study analyzed the relationship between CD44 expression and magnetic resonance imaging (MRI)-based invasiveness of GBM on a large scale. We also quantitatively evaluated GBM invasion using 5-aminolevulinic acid (5-ALA) spectroscopy to investigate the relationship between CD44 expression and tumor invasiveness as evaluated by intraoperative 5-ALA intensity.
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- This study examined the effectiveness and safety of perampanel (PER) as a prophylactic treatment to prevent early seizures in patients with brain tumors, including glioblastoma (GBM).
- A total of 45 patients received PER after tumor resection, with no early seizures reported and minimal side effects observed, such as somnolence and vertigo.
- The results indicated that PER was as effective and safe as levetiracetam (LEV) in preventing seizures, with no major complications or adverse reactions noted in either group.
Introduction And Importance: Spindle cell oncocytoma (SCO) of the pituitary gland is very difficult to differentiate from other pituitary neoplasms and is often misdiagnosed based on imaging procedure features. We report a rare case of SCO arising from the neurohypophysis and suggest a useful diagnostic criterion for accurate diagnosis and surgical pitfalls.
Case Presentation: A 53-year-old man was admitted to our hospital with slight headache and diplopia.
Background: The ventriculus terminalis (VT) is a cystic embryological remnant of the conus medullaris that usually regresses after birth. This structure rarely persists into adulthood and may produce neurological symptoms. We recently encountered three cases of symptomatic enlarging VT.
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- The study aimed to assess the effectiveness of zero-echo-time (ZTE)-based MRI in helping plan surgeries and providing anatomical guidance during transcranial procedures.
- Researchers analyzed data from 11 out of 26 patients who had undergone transcranial surgery, comparing ZTE/MRA fusion images and 3D ZTE MRI models to traditional imaging methods.
- Results showed ZTE-based imaging offered clear views of cranial anatomy without radiation or contrast, aiding in planning for certain conditions while proving less effective for others, particularly those involving the skull base.