Publications by authors named "Akihiko Yuki"
Neurocutaneous melanosis (NCM) is a rare congenital neurocutaneous syndrome characterized by congenital melanocytic nevus of skin and abnormal proliferation of leptomeningeal melanocytes. Early acquisition of post-zygotic somatic mutations has been postulated to underlie the pathogenesis of NCM. The pathogenesis of NCM remains to be fully elucidated, and treatment options have not been established.
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- Deep dermatophytosis is a serious fungal infection that typically affects immunocompromised individuals, linked recently to a deficiency in the CARD9 protein.
- In a reported case, an 80-year-old Japanese man developed this infection after presenting with skin lesions, leading to severe complications despite antifungal treatment, including the amputation of his left leg.
- Genetic testing confirmed a specific mutation in the CARD9 gene, highlighting the connection between this deficiency and the exacerbated fungal infection.
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- Dermoscopy is an effective diagnostic tool for basal cell carcinoma (BCC), particularly in Japanese patients, with a sensitivity of 92.2% and specificity of 96.0%.
- The study analyzed 934 BCC cases from a larger pool of skin lesions, revealing that the most common misdiagnoses included seborrheic keratosis and melanocytic nevus.
- Lower sensitivity was noted for BCCs located on the trunk and extremities with less pigmentation, highlighting the importance of experience for dermatologists to improve diagnostic accuracy.
Cutaneous syncytial myoepithelioma (CSM) is a recently recognized variant of myoepithelioma characterized by an intradermal syncytial proliferation of spindled, ovoid, and histiocytoid cells. Immunohistochemically, tumor cells usually show strong expression of S-100 protein and epithelial membrane antigen (EMA). Here we report a case of CSM in the thigh of a 51-year-old Japanese woman.
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- Botryomycosis is a rare bacterial infection that mimics mycetoma and can affect both immunocompromised and immunocompetent individuals, commonly presenting as a chronic granulomatous infection with sulfur granules.
- An 8-year-old boy with a 4-mm subcutaneous tumor on his heel was diagnosed with botryomycosis after surgical removal and histopathological analysis revealed Gram-positive cocci and the Splendore-Hoeppli phenomenon.
- The patient was treated effectively with surgical excision and antibiotics, and the case highlights the importance of early detection and investigation of small lesions to prevent more severe infections.
Background: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. Early-stage MF patches or plaques often resemble inflammatory skin disorders (ISDs), including psoriasis and atopic dermatitis. Cell adhesion molecule 1 gene (CADM1), which was initially identified as a tumor suppressor gene in human non-small cell lung cancer, has been reported as a diagnostic marker for adult T-cell leukemia/lymphoma.
View Article and Find Full Text PDFNivolumab is an antibody against programmed cell death 1 and functions as an immune checkpoint inhibitor for various malignancies, including unresectable melanomas. Nivolumab causes several immune-related adverse events, which typically include skin rash, pneumonitis, thyroid dysfunction, hepatitis, and colitis; in rare cases, anemia may be present. There are several reports of autoimmune hemolytic anemia that has developed in response to nivolumab; however, there are few reports of pure red cell aplasia (PRCA).
View Article and Find Full Text PDFTie-over bolster dressing after skin grafting can prolong operative time, and cause hematoma and seroma formation because of uneven pressure application. To describe the possibility of discontinuing the use of tie-over dressing, we carried out a retrospective comparative study of patients who underwent skin grafting at an institution between January 2009 and December 2014. We investigated and compared the take rate, healing period, wound infection rate and hematoma formation rate for the tie-over dressing group and the non-tie-over dressing group.
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