Publications by authors named "Akihiko Misawa"

Article Synopsis
  • The preoperative diagnosis of ovarian lymphoma is challenging, often leading to surgeries intended for ovarian cancer due to misdiagnosis.* -
  • A case study details a 55-year-old woman where single-port laparoscopic surgery helped accurately diagnose primary ovarian lymphoma after initial imaging suggested ovarian cancer.* -
  • The successful diagnosis through this minimally invasive technique underscores its importance for early treatment in cases of advanced ovarian cancer.*
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Pregnant patients have an increased risk of torsion compared to that seen in nonpregnant patients, and those with larger cysts undergo torsion more frequently, which can cause obstructions during labor. The risks associated with emergent surgery are higher than those with elective surgery. Laparoscopic surgery can be safely performed during pregnancy.

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Introduction: In advanced epithelial ovarian cancer (AEOC), it is often difficult to achieve optimal surgery at primary debulking surgery (PDS) due to intra-abdominal dissemination and/or metastasis. When it is determined that optimal surgery is not possible, neoadjuvant chemotherapy (NAC) is performed prior to subsequent debulking surgery. Also, a histological diagnosis of the tumor is very important before initiation of NAC.

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Teratomas of extragonadal origin are extremely rare. The most common extragonadal site is the greater omentum. A 36-year-old woman was referred to our department for treatment of bilateral ovarian tumors.

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Ovarian epidermoid cyst, an extremely rare tumor occurring mostly in older females, is lined by mature stratified squamous epithelium and distinguishable from mature teratoma by the absence of skin adnexae and other tissues. In imaging, these tumors resemble solid tumors, necessitating most patients to undergo oophorectomy to verify malignancy. We herein present the case of an ovarian epidermoid cyst in a pregnant woman who underwent laparoscopic cystectomy after delivery with preserved ovarian function.

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Standard chemotherapy for endometrial cancer, including therapy with adriamycin and cisplatin (AP therapy), has not been established. However, recently, many studies have reported the efficacy of taxanes. We retrospectively investigated 46 patients with endometrial cancer who were diagnosed and treated in our hospital.

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The current initial standard chemotherapy for advanced ovarian cancer is a regimen with a combination of platinum and taxane. However, the 5-year survival rate remains at 40% or lower, and the recurrence rate is as high as 70-80%. Second-line chemotherapy for recurrent cases has not yet been established.

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The cell line designed JHUCS-1 was established from a carcinosarcoma (malignant mixed mesodermal tumor) of the uterus that was surgically removed from a 57-year-old Japanese woman. We carefully examined the histopathology of the original tumor after the cell line was established and noted differentiation into a neuroendocrine carcinoma within the tumor's epithelial components. Immunohistochemical staining of the tumorous tissue that had been heterotransplanted was positive for Leu7.

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We report herein on the efficacy and toxicity of docetaxel and carboplatin in patients with epithelial ovarian cancer. Fifteen patients with FIGO stage I c-IV epithelial ovarian cancer were administered docetaxel (70 mg/m2) and carboplatin (AUC 5) every 3 weeks as 1 course. Eleven patients received this regimen as a first-time chemotherapy, and the other 4 as therapy for recurrence.

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