Publications by authors named "Akifumi Goto"
Article Synopsis
- - Aging leads to a condition called sarcopenia, characterized by the loss of skeletal muscle mass and function, significantly affecting the quality of life for older adults and increasing hospitalization rates.
- - Caloric restriction (CR) has been found to counteract age-related changes and may delay the onset of sarcopenia, but research on its long-term effects on muscle atrophy is limited.
- - In a study comparing different age groups of rats, it was discovered that while advanced aging notably diminished muscle size and health, long-term CR successfully preserved muscle mass and fiber integrity, reducing the negative impacts of sarcopenia.
Despite the similar phenotypes, including weight loss, reduction of food intake, and lower adiposity, associated with caloric restriction (CR) and cancer cachexia (CC), CC is a progressive wasting syndrome, while mild CR improves whole body metabolism. In the present study, we compared adipose metabolic changes in a novel rat model of CC, mild CR (70% of the food intake of control rats, which is similar to the food consumption of CC rats), and severe CR (30% of the food intake of controls). We show that CC and severe CR are associated with much smaller adipocytes with significantly lower mitochondrial DNA content; but, that mild CR is not.
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