Publications by authors named "Aki Yoshii"
Article Synopsis
- This study evaluated the effectiveness of anabolic agents (romosozumab and teriparatide) versus alendronate in preventing subsequent vertebral body fractures (SVBFs) after balloon kyphoplasty (BKP) in patients with osteoporosis.
- Results showed that both anabolic agents significantly reduced SVBF incidence compared to alendronate, with romosozumab being the most effective in increasing bone mineral density (BMD) and preventing distant vertebral fractures.
- The study included 603 patients and highlighted that those on anabolic agents had a lower risk of repeat BKP and better BMD improvements compared to those on alendronate.
Study Design: Retrospective cohort study.
Purpose: To evaluate the efficacy of our current prophylactic strategy by investigating the incidence of subsequent vertebral body fractures (SVBFs) following balloon kyphoplasty (BKP).
Overview Of Literature: Although extensive studies have investigated the risk factors for SVBFs after BKP, few have reported on postoperative therapies to prevent SVBFs and have evaluated their effectiveness.
Crohn's disease (CD) is an intractable inflammatory bowel disease, and dysbiosis, disruption of the intestinal microbiota, is associated with CD pathophysiology. ER stress, disruption of ER homeostasis in Paneth cells of the small intestine, and α-defensin misfolding have been reported in CD patients. Because α-defensins regulate the composition of the intestinal microbiota, their misfolding may cause dysbiosis.
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