Changes in blood biochemical parameters in highly productive cows with ketosis.

Background And Aim: Biochemical blood testing is the main diagnostic indicator of the clinical condition of highly productive animals and a method of determining changes in metabolic disorders. This study focuses on metabolic changes (ketosis), which are of the utmost importance in the assessment of the health status of animals, as well as differences in intergroup characteristics. The main focus of this study is to demonstrate the influence of subclinical ketosis in highly productive cows on changes in biochemical blood parameters during different physiological periods to further prevent this disease, adjust feeding rations, and prevent premature culling of animals.

[Experience with the treatment of diabetic coma].

To investigate the effect of low-dose versus high-dose insulin treatment of Kussmaul's coma, the authors treated 2 groups of relevant patients. Group I treated with low-dose insulin in combination with other therapeutic measures achieved a progressive decrease of glycemia within 8 hours. Complications were not registered.

[Comparative characteristics of the lipid composition of lipoproteins of the blood plasma and ascitic fluid in liver cirrhosis].

Comparison of phospholipid content in different fractions of lipoproteins of the ascitic fluid and blood plasma showed selective accumulation of high density lipoproteins (HDLP) in the ascitic fluid. The ascitic fluid HDLP differed from blood plasma HDLP in a larger fraction of triglycerides and cholesterol oleate. No significant difference was revealed in the lipoprotein (LP) low density lipid spectrum in the two fluids.

[The role of structural heterogeneity of circulating lipids in the regulation of lipoprotein metabolism in the plasma and lymph in hypercholesterolemia in dogs].

Fatty acid spectrum of lipoproteins was studied in intestinal steam lymph and blood plasma of dogs with alimentary hypercholesterolemia. Mechanism of cholesterol accumulation in blood plasma appears to relate to increase in content of cholesterol palmitate which is secreted from intestine into lymph and hydrolyzed slowly in liver tissue. Alterations in composition of fatty acid acyls of cholesterol esters, of phosphatidyl cholines and triacyl glycerides as well as effect of these alterations on the lecithin-cholesterol acyl-transferase reaction and lipoprotein lipolysis are discussed.

[Clinical and experimental study of the effect of obsidan and hemiton on the blood kallikrein-kinin system].

In 52 patients with labile hypertension and also in experimental hypertension in 52 rats dynamics of kallikrein-kinin system in the blood during obsidan and hemiton treatment has been studied to find relationship between the hypotensive action of these drugs and the blood kinins activity. It was found that there exist counter-directional shifts in the kallikrein-kinin system of the blood as a result of treatment depending on their initial level. Adequate therapy contributed to the maintenance of optimum kinin concentration for preservation of homeostasis.

[Lipid peroxides and atherosclerosis. Free radical peroxidation of polyene lipids in the blood in ischemic heart disease].

Examination of blood in 114 males (35--60 years of age) with stage III of lipid hydroperoxides, acylhydroperoxides, intermol ecular cross-links in the aminophosphatides and secondary products of lipoperoxidation was increased considerably as compared to that in practically healthy males (30) of the same age. The activity of blood glutathione lipoperoxidase in the examined group of patients was sharply reduced.

[Lipid peroxides and atherosclerosis. The content of lipid peroxidation products in the blood in ischemic heart disease].

It was established that the content of primary (acylhydroperoxide) and secondary (intermollecular "seams" in aminophospholipids) products of lipid peroxide oxidation in blood of patients with ischemic heart disease is increased against the background of hyperlipidemia and hypercholesterolemia. It is suggested that intensification of lipid peroxide oxidation may play a role in the pathogenesis of atherosclerosis.