Exploring of anisotropy of acousto-optic interaction in lead molybdate crystals.

The dependence of the elastic and acousto-optic properties of lead molybdate crystals on the direction of the wave vector and the polarization of acoustic and optical waves has been studied. The effective photoelastic constants were determined by the Dixon method for various geometries of the Bragg light diffraction. The dependence of the acousto-optic quality factor on the direction of the wave vector of longitudinal acoustic waves in the symmetry plane has been studied in detail.

Pneumonitis After Concurrent Chemoradiation and Immune Checkpoint Inhibition in Patients with Locally Advanced Non-small Cell Lung Cancer.

Aims: Pneumonitis is a common and potentially deadly complication of combined chemoradiation and immune checkpoint inhibition (CRT-ICI) in patients with locally advanced non-small cell lung cancer (LA-NSCLC). In this study we sought to identify the risk factors for pneumonitis with CRT-ICI therapy in LA-NSCLC cases and determine its impact on survival.

Materials And Methods: We conducted a retrospective chart review of 140 patients with LA-NSCLC who underwent curative-intent CRT-ICI with durvalumab between 2018 and 2021.

Incidence and Risk Factors for Pneumonitis Associated With Checkpoint Inhibitors in Advanced Non-Small Cell Lung Cancer: A Single Center Experience.

Introduction: Immune checkpoint inhibitor (ICI) pneumonitis causes substantial morbidity and mortality. Estimates of real-world incidence and reported risk factors vary substantially.

Methods: We conducted a retrospective review of 419 patients with advanced non-small cell lung cancer (NSCLC) who were treated with anti-PD-(L)1 with or without anti-CTLA-4 therapy.

Selinexor in combination with weekly paclitaxel in patients with metastatic solid tumors: Results of an open label, single-center, multi-arm phase 1b study with expansion phase in ovarian cancer.

Objective: Selinexor is a first-in-class, oral selective inhibitor of nuclear export (SINE) compound which blocks Exportin-1 (XPO1). Our objective was to determine maximum tolerated dose (MTD) and recommended phase II dose (RP2D) of selinexor and weekly paclitaxel.

Methods: This was an open label, single-center, multi-arm phase 1b study utilizing a "3 + 3" design and a "basket-type" expansion in recurrent solid tumors.

Role of Abdominal and Pelvic CT Scans in Diagnosis of Patients with Immunotherapy-Induced Colitis.

Introduction: Colitis is one of the most common immune-related adverse events in patients receiving immune checkpoint inhibitors. Although radiographic changes on computed tomography (CT), such as mild diffuse bowel thickening, mesenteric fat stranding, and mucosal enhancement, have been reported, the utility of CT in diagnosis of patients with suspected immune-related colitis is not well documented. The aim of this retrospective study was to determine the value of CT scans in diagnosis of immunotherapy-induced colitis.

Pneumonitis after immune checkpoint inhibitor therapies in patients with acute myeloid leukemia: A retrospective cohort study.

Background: Immune checkpoint inhibitors (ICI), combined with hypomethylating agents, can be used to treat acute myeloid leukemia (AML), but this strategy results in a high rate of pneumonitis. The authors sought to determine risk factors for pneumonitis development and whether pneumonitis increased mortality.

Methods: The authors conducted a retrospective review of 258 AML patients who received ICI-containing regimens from 2016 to 2018.

Phase II Clinical Trial of Pembrolizumab in Patients with Progressive Metastatic Pheochromocytomas and Paragangliomas.

Metastatic pheochromocytomas and paragangliomas (MPPGs) are rare endocrine malignancies that are associated with high rates of morbidity and mortality because of their large tumor burden and location, progression, and release of catecholamines. Systemic therapies for MPPGs are limited. MPPGs are characterized by pseudohypoxia that may prevent immune system recognition.

[Retrospective analysis of the efficiency of radiation studies in closed injury to the lower cervical spine (C3-C7)].

The paper presents the results of an analysis of the efficiency of radiation diagnostic techniques in 101 patients with closed injury to the lower cervical spine. The analysis was made by comparing the data of study protocols with surgical findings and pathologists' reports. The sensitivity, specificity, and toxicity of X-ray study, computed tomography (CT), and magnetic resonance imaging (MRI) are presented in bony, soft tissue, and neural structural damages.

[Role of spiral computed tomographic angiography in the diagnosis of aortic aneurysmal complications].

The paper considers the basic diagnostic capacities of computed tomographic angiography (CTA) in aortic aneurysmal complications. The results of emergency of CTA were analyzed In 63 patients with suspected aortic aneurysmal dissection and rupture. CTA provides complete information on the site, extent, and spread, form and sizes of an aneurismal process, on the presence of intraluminal thrombi, on the presence or absence of aortic wall dissection and rupture, on the involvement of aortic branches, and the state of adjacent tissues and organs.

[Structum therapy of patients with rheumatoid arthritis].

Aim: To study efficacy of the chondroprotector chondroitin sulphate (structum, Pier Fabr Medicament Production, France) in patients with rheumatoid arthritis (RA) and secondary osteoarthrosis of the knee joints.

Material And Methods: 15 women with a long history of RA (mean duration 11.9 years) entered an open non-randomized trial of structum.