[The analysis of self-evaluation of stomatological health in patients with partial absence of teeth].

The aspects related to self-assessment of dental health in patients with partial absence of teeth were analyzed using questionnaire survey, clinical examination of patients and extracting data from health questionnaires from patient's medical records were studied. Patients with a partial absence of teeth most often admit to dental medical organization with complaints about impaired chewing function. At the same time, most of respondents with largest number of such complaints belong to older age groups: 45-54 and 55-62 years.

[Biochemical markers of myocardium damage in children with cardiomyopathy.].

The article presents the results of studies of 104 patients with cardiomyopathy hospitalized in the cardiorheumatological departments of the Republican Specialized Scientific and Practical Medical Center of Pediatrics in Tashkent and the Republican Children's Multidisciplinary Medical Center of the Republic of Karakalpakstan. An analysis of the results of the study showed that in children with cardiomyopathy there is an increase in the level of tissue (LDH, CPK) and cardiospecific (CPK-MB) enzymes, regardless of the region of residence and the form of the disease, which indicate myocardial dysfunction. Therefore, these enzymes can be regarded as highly specific biochemical markers of myocardial damage, and an increase in their activity can be used as criteria for the diagnosis of heart disease.

[Impairement of the platelet lipid membrane composition in severe angina pectoris].

Investigation was performed on 54 patients with angina pectoris. The patients were divided into three groups. Group 1 included patients with angina pectoris of functional classes I-II, group 2 consisted of the patients with angina pectoris classes III-IV, and group 3--unstable angina pectoris.

[Hemolytic effect of phospholipase A2 and orientotoxin from venom of the great hornet, Vespa orientalis].

The effect of toxic phospholipase A2 and orientotoxin from the venom of the giant hornet Vespa orientalis on human erythrocytes was studied. It was shown that these venom components are potent hemolytic agents, the efficiency of the latter being by about two orders of magnitude as high as that of phospholipase A2. The hemolytic function of the both components is enhanced in the presence of low concentrations of Ca2+, whereas high concentrations of this cation exert an inhibiting action.

[Low molecular weight peptides from the venom of the giant hornet Vespa orientalis. Structure and function].

Three 14-member linear peptides (HR-1, HR-2 and HR-3) capable of degranulating mast cells and thus initiating histamine release were isolated from the venom of the giant hornet Vespa orientalis, using reverse phase high performance liquid chromatography. The complete amino acid sequence of the peptides HR-1 and HR-2 molecules and partial structure of peptide HR-3 were determined, using automatic degradation by the Edman method. It was shown that peptide HR-1 at relatively low concentrations (2-20 micrograms/ml) selectively liberated histamine from rat mast cells and, when taken at higher doses (50-100 micrograms/ml), exerted a non-selective cytotoxic action.

[Use of a portable drug administration system for long-term insulin administration to diabetics].

The efficacy of a prolonged (an average of 24.2 days) subcutaneous insulin administration using a Soviet apparatus NDL (a portable drug dosing apparatus) of paracorporal type was studied in 30 patients with type I diabetes mellitus. As a result of therapy a stable compensation of carbohydrate metabolism was achieved in 26 patients, subcompensation in 4 patients; glycemia circadian variations and requirements in insulin in most cases decreased.

[Fluorescence proper of phospholipase A2 and orientotoxin from the venom of the giant hornet in the presence of ionic modulators of their membrane activity].

The own fluorescence of phospholipase A2 and orientotoxin at interaction of these components from Oriental hornet venom with calcium, strontium, lantan, magnesium ions has been investigated. Ca2+, La3+, Sr2+--activators of phospholipase activity--increase the quantum output of fluorescence. In the presence of Ca2+ the temperature of semitransitional process of thermoinactivation of investigated polypeptides increases by 2 degrees C.

[Sugar transport regulation in vitro by new calcium ionophores].

The influence of calcium ionophores--tenoyltrifluoroacetate (TTFA) and divaleryldibenzo-18-crown-6(divaleryl) on the glucose consumption, D-xylose transport and glycogen content in rat diaphragm was studied. TTFA caused a clear dose-dependent inhibition of carbohydrate transport and glycogenolysis stimulation. Divaleryl, on the other hand, raised glucose consumption, D-xylose transport without influencing glycogen content.

[Characterization of some membrane-active components of Vespa orientalis venom].

The molecular weight distribution of the components of giant hornet (Vespa orientalis) venom was studied, using gel-filtration on a column with Sephadex G-50. The effects of the venom and its constituent fractions on the permeability and stability of artificial bilayer phospholipid membranes, potassium ions release from the erythrocytes and mitochondrial oxidative phosphorylation parameters, as well as on the activity and stability of polyenzymic systems of the mitochondrial respiratroy chain, were studied. The data obtained suggest that the high molecular weight fractions contain phospholipases, whose activities are much higher than those of presently known venoms.