[Transurethral resection and buccal mucosal graft for the treatment of refractory bladder neck contracture].

Bladder neck contracture after prostate surgery is a rare but feared complication. The treatment of choice is endoscopic incision or resection of fibrotic tissue. In case of ineffective transurethral correction, bladder neck reconstruction has to be done.

The effect of flaxseed oil consumtion on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials.

We systematically reviewed randomized clinical trials (RCTs) to elucidate the overall effects of flaxseed oil consumption on blood pressure (BP) in patients with metabolic syndrome and related disorders. PubMed, Scopus, Cochrane Library, and ISI Web of Science databases were systematically searched until March 31, 2020, to find RCTs that examined the effect of flaxseed oil consumption on BP. Weighed mean difference (WMD) was pooled using a random-effects model.

Synapse Formation Activates a Transcriptional Program for Persistent Enhancement in the Bi-directional Transport of Mitochondria.

Mechanisms that regulate the bi-directional transport of mitochondria in neurons for maintaining functional synaptic connections are poorly understood. Here, we show that in the pre-synaptic sensory neurons of the Aplysia gill withdrawal reflex, the formation of functional synapses leads to persistent enhancement in the flux of bi-directional mitochondrial transport. In the absence of a functional synapse, activation of cAMP signaling is sufficient to enhance bi-directional transport in sensory neurons.

Analysis of the course of rheumatoid arthritis depending on the climatic and geographic zones of Uzbekistan.

The aim of this study was to evaluate the features of rheumatoid arthritis (RA) as well as other health problems and treatment necessities in various climatic and geographic zones of Uzbekistan. The data on 2013 patients with a confirmed diagnosis of RA were collected retrospectively. The results showed that the Khorezm and Surkhandarya regions dominated by indicators of disease activity and severity, such as a more expressed progressive course; in addition, marked alterations in the reproductive system, especially in women, were observed as well.

New approach to capture and characterize synaptic proteome.

Little is known regarding the identity of the population of proteins that are transported and localized to synapses. Here we describe a new approach that involves the isolation and systematic proteomic characterization of molecular motor kinesins to identify the populations of proteins transported to synapses. We used this approach to identify and compare proteins transported to synapses by kinesin (Kif) complexes Kif5C and Kif3A in the mouse hippocampus and prefrontal cortex.

Huntingtin is critical both pre- and postsynaptically for long-term learning-related synaptic plasticity in Aplysia.

Patients with Huntington's disease exhibit memory and cognitive deficits many years before manifesting motor disturbances. Similarly, several studies have shown that deficits in long-term synaptic plasticity, a cellular basis of memory formation and storage, occur well before motor disturbances in the hippocampus of the transgenic mouse models of Huntington's disease. The autosomal dominant inheritance pattern of Huntington's disease suggests the importance of the mutant protein, huntingtin, in pathogenesis of Huntington's disease, but wild type huntingtin also has been shown to be important for neuronal functions such as axonal transport.

Asymmetric localization of natural antisense RNA of neuropeptide sensorin in Aplysia sensory neurons during aging and activity.

Despite the advances in our understanding of transcriptome, regulation and function of its non-coding components continue to be poorly understood. Here we searched for natural antisense transcript for sensorin (NAT-SRN), a neuropeptide expressed in the presynaptic sensory neurons of gill-withdrawal reflex of the marine snail Aplysia californica. Sensorin (SRN) has a key role in learning and long-term memory storage in Aplysia.

Aplysia Ganglia preparation for electrophysiological and molecular analyses of single neurons.

A major challenge in neurobiology is to understand the molecular underpinnings of neural circuitry that govern a specific behavior. Once the specific molecular mechanisms are identified, new therapeutic strategies can be developed to treat abnormalities in specific behaviors caused by degenerative diseases or aging of the nervous system. The marine snail Aplysia californica is well suited for the investigations of cellular and molecular basis of behavior because neural circuitry underlying a specific behavior could be easily determined and the individual components of the circuitry could be easily manipulated.

Decreased response to acetylcholine during aging of aplysia neuron R15.

How aging affects the communication between neurons is poorly understood. To address this question, we have studied the electrophysiological properties of identified neuron R15 of the marine mollusk Aplysia californica. R15 is a bursting neuron in the abdominal ganglia of the central nervous system and is implicated in reproduction, water balance, and heart function.

Age-associated bidirectional modulation of gene expression in single identified R15 neuron of Aplysia.

Background: Despite the advances in our understanding of aging-associated behavioral decline, relatively little is known about how aging affects neural circuits that regulate specific behaviors, particularly the expression of genes in specific neural circuits during aging. We have addressed this by exploring a peptidergic neuron R15, an identified neuron of the marine snail Aplysia californica. R15 is implicated in reproduction and osmoregulation and responds to neurotransmitters such as acetylcholine, serotonin and glutamate and is characterized by its action potential bursts.

Effective management of combined renewable energy resources in Tajikistan.

Water is needed mostly in summer time for irrigation and in winter time for generation of electric power. This results in conflicts between downstream countries that utilize water mostly for irrigation and those upstream countries, which use water for generation of electric power. At present Uzbekistan is blocking railway connection that is going to Tajikistan to interfere to transportation of the equipment and materials for construction of Rogun hydropower plant.

Observed influence of nitroglycerine on myocardial perfusion scintigraphy in patients with multiple vessel coronary artery disease and well-developed collaterals.

The objective of this scientific work was to evaluate the extent and severity of perfusion abnormalities on myocardial perfusion scintigraphy (MPS) at rest and with sublingual nitroglycerine, in relation to the presence and anatomical location of collaterals demonstrated by selective coronary angiography (SCA). Twenty-eight patients with unstable angina underwent selective coronary angiography. Eighteen of them were diagnosed with myocardial infarction (MI) 2-15 days prior to examination.

[Effect of combined therapy using complex of natural cytokines and antimicrobial peptides in urogenital infections caused by Chlamydia and Mycoplasma].

Aim: To study efficacy of complex therapy of urogenital infections caused by Chlamydia and Mycoplasma using immunomodulator Superlimph.

Materials And Methods: Fifty males and thirty six females ages 22 - 47 years old with chronic urogenital infections--cervicitis and vulvovaginitis (females), prostatitis (males)--were studied. PCR and bacteriologic methods were used for diagnostics of mixed infection and microbiota efficiency.

[Genetic aspects of microphylogeny of black-and-white cattle of Uzbekistan].

The genetic aspects of microphylogeny of herds of black and white cattle of Asian and European populations have been studied on the basis of distribution analysis of frequency in 62 antigens of 11 systems of blood groups.

[The action of the venom of the spider Eresus niger on the neuromuscular synapses of the frog].

The effect of Eresus niger spider venom on frog neuromuscular preparations has been studied using the intracellular microelectrodes. The spider venom has been found to block both spontaneous and elicited transmitter release and possesses the phospholipase activity. It has been suggested that the venom blocking synaptic transmission results from its phospholipase activity by analogy with the action of snake presynaptic neurotoxins.

[Capillary filtration coefficient and the distensibility of the venous vessels of the small intestine in the process of high-altitude adaptation].

In acute experiments on cats, the increase of capillary filtration coefficient and venous distensibility in small intestine was revealed after 3-5, 14-16 and 29-31 days of high altitude adaptation (The Pamirs, 3370 m above sea level), the changes being more obvious (by 78% and 45%, resp.) after 3-5 days in comparison with low altitude control. The effects of noradrenaline on the small intestine precapillary sphincters and venous distensibility were preserved at high altitude, whereas regional blockade of alpha- or beta-adrenoreceptors exerted no effect on the results.

[Adrenoreactivity of the vessels of the small intestine during adaptation to high altitude in the cat].

Responses of the resistance and capacitance vessels of small intestine to adrenergic stimulation and blockade were studied in acute experiments on cats after 3-30 days of high altitude adaptation (the Pamirs, 3370 m). In comparison to control (Dushanbe, 830 m) constrictor responses of the resistance vessels to noradrenaline and adrenaline were significantly increases at high altitude, whereas the dilator responses to beta-stimulator propranolol were obviously reduced. Changes of venous blood outflow from small intestine in response to catecholamines at high altitude exceeded the control values.