CeO@NH functionalized electrodes for the rapid detection of SARS-CoV-2 spike receptor binding domain.

A detection method based on an electrochemical aptasensor has been developed as an alternative fast, portable, simple, inexpensive, and high-accuracy detection method for detecting the SARS-CoV-2 Spike Receptor Binding Domain (spike RBD). The CeO@NH functionalized Screen Printed Carbon Electrode (SPCE) was used to immobilize an aminated aptamer of spike RBD protein glutaraldehyde as a linker. The aptamer's interaction with the SARS-CoV-2 Spike RBD was measured the [Fe(CN)] redox system signal.