The frequent variant A57F in the gene in patients from Russia has Finno-Ugric Mari origin.

Introduction: GNE-myopathy is a distal myopathy with adult-onset and initial involvement of anterior leg compartment. A founder effect has been demonstrated for some patients from several large cohorts in different countries.

Methods: In this study, we investigated the allele frequency of the c.

[Bioregulatory drug Newrexan in the treatment of anxiety and dissomnia. Resolution of the Council of Experts (June 8, 2023)].

Bioregulatory drug Newrexan in the treatment of anxiety and dissomnia. Resolution of the Council of Experts.

[Treatment of cognitive, behavioral and mental disorders in patients with vascular dementia: results of a multicenter, randomized, double-blind, placebo-controlled clinical trial].

Objective: Evaluation of the efficacy and safety of Prospect in the treatment of cognitive, behavioral and mental disorders in patients with vascular dementia (VSD).

Material And Methods: In a double-blind, placebo-controlled, parallel-group randomised clinical trial, 406 patients aged 60-85 years old with a diagnosis of mild/moderate vascular dementia (10-24 on the Mini-Mental State Examination (MMSE)) and without signs of depression (Cornell Scale for Depression in Dementia (CSDD) scores ≤10) were included. At Visit 1, complaints and medical history were collected, vital signs were recorded, cognitive impairment was assessed using MMSE and MoCA, NPI-C and CSDD were completed, and an MRI brain scan was performed.

Can miRNAs Be Considered as Diagnostic and Therapeutic Molecules in Ischemic Stroke Pathogenesis?-Current Status.

Ischemic stroke is one of the leading causes of death worldwide. Clinical manifestations of stroke are long-lasting and causing economic burden on the patients and society. Current therapeutic modalities to treat ischemic stroke (IS) are unsatisfactory due to the intricate pathophysiology and poor functional recovery of brain cellular compartment.

The role of microglia in the development of neurodegeneration.

Microglia-mediated central nervous system (CNS) inflammation is one of the key features of various neurodegenerative diseases, including Parkinson's and Alzheimer's diseases. In the last few years, a number of studies have investigated the link between neurodegenerative diseases and CNS glial cells, in particular microglia. Microglial cells are the main resident immune cells and comprise approximately 10-15% of all CNS cells.

[Migraine burden and clinical inertia: what can we do?].

Aim: To study the compliance of neurologists and headache specialists to chronic headache and chronic migraine (CM) diagnosis and treatment guidelines.

Material And Methods: The survey included 634 neurologists from all regions of the Russian Federation. Mean age of respondents was 40.

['Point of no return' in diabetic neuropathies: a dangerous delusion].

Polyneuropathy in patients with diabetes mellitus is manifested by a lesion of peripheral sensory, motor and autonomic nervous system. Different severity of damage of sensory, motor and autonomic fibers in typical and atypical forms of diabetic polyneuropathy, requires a differentiated approach to therapy, but not the rejection of its implementation. In an interdisciplinary consensus, consultations are held with physicians from different regions of the Russian Federation, and modern methods of diagnosing and assessing the severity of diabetic polyneuropathies, which determine the algorithm for treating patients, are discussed.

[Sleep disorders in neurological department and Kleine-Levin syndrome].

The authors present a case-report of a 22-year-old man with Kleine-Levin syndrome (KLS) and consider the historical description of the syndrome, its symptoms, diagnostic criteria, its place in modern classifications of sleep disorders and KLS pathogenesis. Own data on the frequency of different sleep disorders in inpatients of a neurological unit are presented.

[Efficiency of post-stroke rehabilitation measures at hospital: quantitative analysis of motor function recovery].

Background: Mobility recovery is one of the main purposes of physical rehabilitation after acute stroke and in a number of other neurological diseases.

Aim: To quantify the efficiency of rehabilitation measures in patients after stroke and to compare the effectiveness of motor function restoration in patients in the acute phase of stroke and in the early recovery period.

Methods: Examinations were made in 116 patients aged 27 to 88 years who had experienced a stroke (75% of ischemic stroke cases) and been admitted to the Department of Medical Rehabilitation.

[An impact of affective and cognitive impairment on the quality of life in patients with lymphoproliferative diseases].

Aim: To assess the neurological and cognitive status, identify the frequency of anxiety and depression in patients with lymphoproliferative diseases, and analyze their impact on the quality of life of patients.

Material And Methods: Fifty-eight patients, including 35 (60.34%) men and 23 (39.

[Ways of optimizing the management of patients with migraine in Russia (resolution of the council of experts)].

Migraine is the third most common disease in the world. The overall prevalence of migraine in the Russian Federation is estimated at 20% with an estimated global prevalence of 14.7%.

Individualism-Collectivism, Social Self-Control and Adolescent Substance Use and Risky Sexual Behavior.

Individualism and collectivism are cultural syndromes that have been associated with adolescent problem behavior in studies conducted in the U.S. and Southeast Asia.

[Depression and depression-related disorders after a subarachnoid hemorrhage].

Psychiatric disorders often develop after subarachnoid hemorrhage (SAH); the most frequent of them are depression and depression-related disorders (anxiety, apathy, pathological fatigue, posttraumatic stress disorder, etc.). Both biological and psychological mechanisms may underlie the development of these disorders.

[Pathological fatigue and fatigability after stroke].

Aim: To compare the phenomena of pathological fatigue and fatigability in patients after stroke.

Material And Methods: Forty-two patients were examined 6-24 months after stroke onset. Fatigue and fatigability were assessed by Russian versions of the Fatigue Assessment Scale and the Dutch Exertional Fatigue Scale, respectively.

[The early post-stroke mobilization].

Early mobilization is an important prerequisite for the successful recovery after stroke. However, it is unclear at present how early mobilization should be started after stroke. Three randomized controlled trials were devoted to the comparison of the effectiveness and safety of very early (within the first day after stroke) and early (within two days after stroke) mobilization.

[Impairment of attention in post-stroke fatigue and depression].

Objective: To study the relationship between impairment of attention and development of pathological fatigue and depression after non-disabling stroke.

Material And Methods: Thirty patients were examined. Attention was assessed by the Attention Network Test (ANT).

[Confusion assessment method for intensive care unit (CAM-ICU)].

Delirium is a serious complication of disorders of nervous system and requires early detection for successful treatment. Confusion assessment method for intensive care unit (CAM-ICU) is a fast and reliable tool for detection of delirium. We performed screening for delirium among patients of neurological ward using CAM-ICU.

[Delirium in the clinical practice of a therapist].

Delirium is a neuropsychiatric condition that may complicate any visceral disease. Its rate is especially high among patients with inflammatory diseases or metabolic disturbances and in the elderly. Brain injury concurrent with an abnormal stress response underlies the development of delirium.

[Posttraumatic stress disorder in patients after stroke].

Objective. To assess the frequency of main symptoms of posttraumatic stress disorder (PTSD) in post stroke patients. Material and methods.

[Delirium in the acute phase of stroke: frequency and predisposing factors].

Delirium is a common complication of stroke worsening its prognosis. In this work we have analyzed the frequency of delirium and factors, predisposing to its development in the population of Russian patients in hyperacute phase of stroke. Twenty two of 96 (around 23%) recruited patients revealed symptoms of delirium according to DSM-IV criteria.

Immediate and six-month effects of Project EX Russia: a smoking cessation intervention pilot program.

This study evaluates the performance of the Project EX tobacco use cessation program in Russian summer recreational camps. An eight-session clinic-based tobacco use cessation program for adolescents was tested during the summer of 2011 in an experimental pilot trial that involved different youth that rotated through camps. Conditions were nested within camps.