Comprehensive insights into mechanism of nanotoxicity, assessment methods and regulatory challenges of nanomedicines.

Nanomedicine has the potential to transform healthcare by offering targeted therapies, precise diagnostics, and enhanced drug delivery systems. The National Institutes of Health has coined the term "nanomedicine" to describe the use of nanotechnology in biological system monitoring, control, diagnosis, and treatment. Nanomedicine continues to receive increasing interest for the rationalized delivery of therapeutics and pharmaceutical agents to achieve the required response while reducing its side effects.

Prescription Precision: A Comprehensive Review of Intelligent Prescription Systems.

Intelligent Prescription Systems (IPS) represent a promising frontier in healthcare, offering the potential to optimize medication selection, dosing, and monitoring tailored to individual patient needs. This comprehensive review explores the current landscape of IPS, encompassing various technological approaches, applications, benefits, and challenges. IPS leverages advanced computational algorithms, machine learning techniques, and big data analytics to analyze patient-specific factors, such as medical history, genetic makeup, biomarkers, and lifestyle variables.

The Use of Lipid-based Nanocarriers to Improve Ovarian Cancer Treatment: An Overview of Recent Developments.

Ovarian cancer poses a formidable health challenge for women globally, necessitating innovative therapeutic approaches. This review provides a succinct summary of the current research status on lipid-based nanocarriers in the context of ovarian cancer treatment. Lipid-based nanocarriers, including liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs), offer a promising solution for delivering anticancer drugs with enhanced therapeutic effectiveness and reduced adverse effects.

Unveiling the correlation between structural and magnetic ordering in nano CoNiTeO.

Nanomaterials with unique structures and exotic magnetic phenomena are always intriguing; however, the direct correlation of structural and magnetic ordering up to a few nanometers remains critical. We report structural and magnetic properties of sol-gel grown CoNiTeO ( = 0, 0.5 and 1) nanoparticles.

Nearly compensated ferrimagnetic behaviour and giant exchange bias of hexagonal MnPtAl: experimental and theoretical studies.

We have investigated the MnPtAl Heulser alloy to unravel its structural, magnetic, calorimetric and electronic structure properties. At room temperature, the alloy crystallizes in a hexagonal structure. Magnetization reveals a weak martensitic transition at 307 K, followed by a long range ferrimagnetic transition at 90 K.

Magnetic behavior of Ru substituted skyrmion metal MnSi.

We report on the structural and magnetic properties of Ru substituted skyrmion metal MnSi i.e. Mn1-xRuSi for the nominal compositions of0⩽x⩽0.

Experimental and Theoretical Investigations of Fe-Doped Hexagonal MnNiGe.

We report a comprehensive investigation of MnNiFeGe Heusler alloy to explore its magnetic, caloric, and electrical transport properties. The alloy undergoes a ferromagnetic transition across ∼ 212 K and a weak-antiferromagnetic transition across ∼ 180 K followed by a spin-glass transition below ∼ 51.85 K.

Non-collinear antiferromagnetism to compensated ferrimagnetism in Ti(FeCo) ( = 0, 0.5 and 1) alloys: experiment and theory.

The manifestation of the structural and magnetic properties of Co substituted TiFe2 is investigated using powder X-ray diffraction, magnetization and density functional theory calculations. The alloys TiFe2 and TiFeCo crystallize in the hexagonal structure (P63/mmc) with a reduction in the lattice parameters of TiFeCo (by about 0.51% in a and 0.

Anomalous magnetic properties in LaFeAl.

We report the magnetic relaxation, DC magnetization, heat capacity, and X-ray powder diffraction studies of a melt-spun LaFeAl compound executed across a temperature range of 5 to 300 K. We have found three magnetic transitions (at temperatures T, T, and T) in this compound in the zero-field cooled (ZFC) mode, and two magnetic transitions (at T and T) in the field-cooled cooling/warming (FCC/FCW) mode. The ferromagnetic transition (FM) at temperature T indicating hysteresis alludes to a magnetic transition of the first-order (FOT) at lower temperatures.

Magnetism of 3d and 4d doped MnTNiGe (T = Fe, Co, Ru and Rh): bulk magnetization and ab initio calculations.

We compare the magnetic properties of 3d (Fe and Co) and 4d (Ru and Rh) transition metals doped MnNiGe using the combined results of magnetization and ab initio calculations. The alloys crystallize in austenite NiIn-type hexagonal phase (space group: P6/mmc) with insignificant difference in the lattice parameters. MnFeNiGe and MnCoNiGe exhibit spin-glass behavior, resulting from the competing ferro- and antiferromagnetic interactions.

Relation of systolic and diastolic epicardial adipose tissue thickness with presence and severity of coronary artery disease (The EAT CAD study).

Background: Recent studies have shown EAT to be an indicator of cardiovascular risk and atherosclerotic plaque development. However, such data is sparse from Indian sub-continent. The present study evaluated the relationship of EAT as determined by echocardiography to the presence and severity of coronary artery disease (CAD).

Real World Experience of a Biodegradable Polymer Sirolimus-Eluting Stent (Yukon Choice PC Elite) in Patients with Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Angioplasty: A Multicentric Observational Study (The Elite India Study).

Background: The durable polymer drug-eluting stents (DPDES) reduce the risk of repeated target vessel revascularisation (TLR) compared with BMS, but are associated with increased risk of late adverse events. In broadly inclusive populations, the biodegradable-polymer drug-eluting stents (BPDES) have favourable results compared with DPDES in the long term. However, its use in primary angioplasty has not been adequately studied, and data of real-world clinical experience is lacking.

Vertebral Hemangioma an Extremely Rare Cause of Spinal Cord Compression in Children: A Case Report.

Symptomatic benign vascular tumors of the bone are rare. Vertebral hemangiomas are rare detectable spinal tumors. Those presenting with neurological deficits are extremely rare.

Revelation of spin glass behavior in Ru doped MnNiGe: experiment and theory.

We report on the nature of the magnetism in Ru substituted MnNiGe using the combined results of x-ray diffraction, dc-magnetization, ac-susceptibility and ab initio calculations. MnRuNiGe crystallizes in NiIn-type hexagonal structure (P6/mmc) at room temperature with lattice parameters a  =  b  =  4.099 [Formula: see text] and c  =  5.

Epidermoid Cyst of the Cerebellopontine Angle Presenting with Contralateral Trigeminal Neuralgia: Extremely Rare Case and Review of Literature.

Background: An epidermoid cyst is a rare tumor of the cerebellopontine angle region. It usually presents with ipsilateral compressive symptoms. The contralateral trigeminal neuralgia is an unusual presentation in such cases.

Extradural Spinal Hamartoma Causing Spinal Cord Compression in an Adolescent Male: An Extremely Rare Case and Review of the Literature.

Spinal hamartoma is an extremely rare, benign spinal lesion occurring in children. It may cause spinal cord compression and subsequent neurological deficits. On reviewing the literature, of a total of 20 cases, only 2 cases are reported in an adolescent age group.

Magnetization, resistivity, specific heat and ab initio calculations of GdSb.

We report on the combined results of the structural, magnetic, transport and calorimetric properties of MnSi-type hexagonal GdSb, together with ab initio calculations. It exhibits a ferromagnetic (FM)-like transition at 265 K, antiferromagnetic (AFM) Néel transition at 95.5 K followed by a spin-orientation transition at 62 K.

Clinical utility of office-based cognitive predictors of fitness to drive in persons with dementia: A systematic review.

Objectives: To perform a systematic review of evidence available regarding in-office cognitive tests that differentiate safe from unsafe drivers with dementia.

Design: A comprehensive literature search of multiple databases including Medline, CINAHL, PsychInfo, AARP Ageline, and Sociofile from 1984 to 2005 was performed. This was supplemented by a search of Current Contents and a review of the bibliographies of all relevant articles.

Systematic review of the optimal frequency of follow-up in persons with mild dementia who continue to drive.

Fitness-to-drive guidelines commonly indicate that persons with mild dementia may be safe to drive but that periodic reevaluation is required. This paper presents the findings of a systematic review of primary evidence regarding the optimal timing of follow-up in persons with mild dementia who continue to drive. A search of Medline, CINAHL, PsychInfo, AARP Ageline, and Sociofile from 1984 to 2005 was performed.