Publications by authors named "Akhila Ramakrishna"
Pathogenicity of visceral adipose tissue (VAT) has been linked to the metabolic stress of enlarging mature adipocytes and a limited ability to recruit new adipocytes. One of the major distinguishing features of VAT preadipocytes is the high expression of the zinc metalloprotease, pregnancy-associated plasma protein-A (PAPP-A), when compared to subcutaneous adipose tissue (SAT). In this study we used 2 different approaches to investigate the effect of PAPP-A inhibition on different fat depots in mice on a high-fat diet (HFD) for 15 weeks.
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- - Heart Rhythm Society guidelines recommend thyroid function tests (TFTs) for adults on amiodarone, but there are no clear recommendations for pediatric patients, despite untreated hypothyroidism posing risks to young children's development.
- - A study analyzed 527 pediatric patients on amiodarone from 1997 to 2017, finding that about 50% showed elevated thyroid-stimulating hormone (TSH) levels, with the highest levels observed in neonates.
- - The findings indicate that younger children, particularly neonates, experience more thyroid dysfunction when treated with amiodarone, highlighting the need for improved monitoring guidelines specifically for pediatric patients.