Visualizing active fungicide formulation mobility in tomato leaves with desorption electrospray ionisation mass spectrometry imaging.

Newer and safer agrochemicals are always in demand to meet the increasing needs of a growing population for affordable food. Spatial chemical monitoring of the active mobility of an agrochemical is essential to this agrochemical development process and mass spectrometry imaging (MSI) is proposed as a safer, easier alternative to the existing standard of autoradiography for the same. With desorption electrospray ionisation mass spectrometry imaging (DESI MSI) using leaf imprints, we were able to visualize the active agrochemical mobility of a commercial fungicide formulation with the active ingredient Azoxystrobin in whole tomato leaves.

Tailoring of 1T Phase-Domain MoS Active Sites with Bridging S/Apical S Phase-Selective Precursor Modulation for Enriched HER Kinetics.

Molybdenum disulfide (MoS) is a promising alternative electrocatalyst for hydrogen evolution reaction (HER) due to its relatively near zero hydrogen adsorption free energy (Δ = 0.08) and availability as a metallic (1T) phase. The superior catalytic activity of the 1T phase over 2H is owing to the availability of dense active sites, 10 fold higher conductivity, and greater hydrophilicity.

Mass Spectrometry Imaging for Spatial Chemical Profiling of Vegetative Parts of Plants.

The detection of chemical species and understanding their respective localisations in tissues have important implications in plant science. The conventional methods for imaging spatial localisation of chemical species are often restricted by the number of species that can be identified and is mostly done in a targeted manner. Mass spectrometry imaging combines the ability of traditional mass spectrometry to detect numerous chemical species in a sample with their spatial localisation information by analysing the specimen in a 2D manner.

Mass Spectrometry Imaging Deciphers Dysregulated Lipid Metabolism in the Human Hippocampus Affected by Temporal Lobe Epilepsy.

Temporal lobe epilepsy (TLE) is the most prevalent form of human epilepsy, often accompanied by neurodegeneration in the hippocampus. Like other neurological diseases, TLE is expected to disrupt lipid homeostasis. However, the lipid architecture of the human TLE brain is relatively understudied, and the molecular mechanism of epileptogenesis is poorly understood.

Chemical analysis of the human brain by imaging mass spectrometry.

Analysis of the chemical makeup of the brain enables a deeper understanding of several neurological processes. Molecular imaging that deciphers the spatial distribution of neurochemicals with high specificity and sensitivity is an exciting avenue in this aspect. The past two decades have witnessed a significant surge of mass spectrometry imaging (MSI) that can simultaneously map the distribution of hundreds to thousands of biomolecules in the tissue specimen at a fairly high resolution, which is otherwise beyond the scope of other molecular imaging techniques.