Publications by authors named "Akhil Kesaraju"
Globally, half a billion people are employed in animal agriculture and are directly exposed to the associated microorganisms. However, the extent to which such exposures affect resident human microbiomes is unclear. Here we conducted a longitudinal profiling of the nasal and faecal microbiomes of 66 dairy farmers and 166 dairy cows over a year-long period.
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- Microbes and antimicrobial resistance genes (ARGs) can move between different environments on dairy farms, but the implications of this transfer are not fully understood.
- Researchers studied manure from dairy cows, examining its journey from fresh manure to manure pits and then to field soil across 15 farms.
- Their findings showed that the composition of microbes changed significantly when manure was stored, but there was no evidence of ARG transfer to field soil, indicating that soil microbes remained stable despite the introduction of manure.
We genetically manipulated the major platelet vesicle-associated membrane proteins (VAMP2, VAMP3, and VAMP8) to create mice with varying degrees of disrupted platelet secretion. As previously shown, loss of VAMP8 reduced granule secretion, and this defect was exacerbated by further deletion of VAMP2 and VAMP3. VAMP238 platelets also had reduced VAMP7.
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