Publications by authors named "Akhil Bhargava"
Article Synopsis
- This study focuses on identifying different immune profiles in sepsis patients based on their body temperature patterns to potentially enable more targeted treatments.
- Researchers categorized 3,576 hospitalized patients with suspected infections into four distinct temperature trajectory subphenotypes and assessed their clinical outcomes and biomarker levels.
- Findings revealed significant differences in mortality rates among these subphenotypes, with the highest mortality in hypothermic patients and notable differences in 20 specific biomarkers across the temperature groups, highlighting the complexity of sepsis.
Objectives: To identify and validate novel COVID-19 subphenotypes with potential heterogenous treatment effects (HTEs) using electronic health record (EHR) data and 33 unique biomarkers.
Design: Retrospective cohort study of adults presenting for acute care, with analysis of biomarkers from residual blood collected during routine clinical care. Latent profile analysis (LPA) of biomarker and EHR data identified subphenotypes of COVID-19 inpatients, which were validated using a separate cohort of patients.