Advances in Understanding How RhoB Regulates Akt Inhibition Efficacy in NSCLC.

Objectives: Increasing the effectiveness and reliability of Akt inhibition in lung cancer treatment may pave the way for a more favorable use of this method in the future. Therefore, we aimed to evaluate the possible role of RhoB in the regulation of Akt inhibition in NSCLC.

Material And Methods: The study was conducted using the NSCLC cell line A549.

Role of macronutrients, dairy products, fruits and vegetables in occurrence and progression of endometriosis: A summary of current evidence in a systematic review.

Background: Current evidence on the role of macro- and micronutrients in the aetiopathogenesis of endometriosis is controversial.

Objectives: In this systematic review, we aimed to investigate the effect of macronutrients, dairy products, fruits, and vegetables on the occurrence and progression of endometriosis.

Materials And Methods: A systematic literature review of eligible articles retrieved from medical databases, including PubMed, Cochrane, and Academic Search, was performed from inception to May 2023.

Avanafil Mitigates Testicular Ischemia/Reperfusion Injury via NLRP3 Pathway Modulation in Rats.

Objective: In our study, the effectiveness of avanafil, a second-generation phosphodiesterase-5 (PDE5) inhibitor, on testicular torsion (TT) related ischemia/reperfusion injury via NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3), which triggers inflammatory response, are studied molecularly, biochemically and histopathologically.

Material And Method: This study was performed on 24 male Wistar albino rats randomized into four groups. Testicular ischemia/reperfusion (I/R) model was created for groups 2, 3 and 4.

Management of menopause in women with a history of endometriosis.

Due to increasing life expectancy, women spend a significant part of their lives in menopause. Women with a history of endometriosis are more likely to become menopausal at an early age due to bilateral oophorectomy or repeated ovarian surgery. In addition, some medical therapies used for endometriosis, such as gonadotropin releasing hormone agonists or progestins reduce bone mineral density.

The effect of dietary habits on oocyte/sperm quality.

The effects of diet and nutritional habits on reproductive cells can be categorized in a variety of ways. In this review, the literature is divided, based on the dietary consumption effects on oocytes and sperm. Topics on dietary patterns and the intrauterine effect of maternal nutrition are covered.

Investigation of Head Shake Sensory Organization Test (HS-SOT) in three planes: Test-retest reliability and age-related differences.

Background: In recent years, it has been determined that SOT sensitivity is insufficient in patients who develop vestibular compensation and therefore the Head Shake Sensory Organization Test (HS-SOT) has been developed.

Research Question: How differs the balance performance of healthy adults that is tested with HS-SOT according to age and test planes? What is the test-retest reliability level of the HS-SOT in three planes?

Methods: Our prospective study, which has a methodological research design, included 80 participants divided into three groups by age range (Group 1: 20-39 years (n = 30); Group 2: 40-49 years (n = 30) and Group 3: 50-64 years (n = 20)). SOT and HSSOT ( yaw, pitch, roll) were performed to all participants.

Sepsis: Immunopathology, Immunotherapies, and Future Perspectives.

Sepsis is a syndrome that includes physiological, pathological, and biochemical abnormalities resulting from the host immune response to infection. Despite the improved treatment modalities in recent years, the incidence and mortality of sepsis are still increasing. Sepsis immunopathology is increasingly attracting the attention of researchers.

Avanafil as a Novel Therapeutic Agent Against LPS-Induced Acute Lung Injury via Increasing CGMP to Downregulate the TLR4-NF-κB-NLRP3 Inflammasome Signaling Pathway.

Aim: We demonstrate the effect of PDE5 inhibitors in cases of acute lung injury via the relationship between cGMP/NO and the TLR4-NF-κB-NLRP3 pathway.

Materials And Methods: This study was performed with 30 male Wistar albino rats. Lipopolysaccharide (LPS) was administered intratracheally to the rats and acute lung injury (ALI) was induced.

Do Meteorological Variations and Climate Changes Affect Hyperemesis Gravidarum?

Background: To estimate a possible association between the effects of daily meteorological variation and climatological changes (temperature, air pressure, humidity, sunniness level) on pregnant women with hyperemesis gravidarum (HG) according to symptoms grade and hospitalization state.

Methods: A retrospective study was conducted with 118 patients diagnosed and hospitalized with HG. HG patients were graded as mild, moderate, or severe according to the Pregnancy Unique Quantification of Emesis (PUQE-24) scale.

The effect of weather variables on the severity, duration, and frequency of headache attacks in the cases of episodic migraine and episodic tension-type headache.

Background/aim: Although many headache patients report that the frequency and severity of attacks vary according to the season or weather in clinical practice, the relationship between the characteristics of the attacks and the weather is not very clear in episodic headaches. We aimed to compare the effects of weather variables (temperature, wind speed, wind direction, humidity, pressure, ultraviolet index, and sunshine duration) on episodic migraine (EM) and episodic tension-type headache (ETTH) attacks (incidence, duration, and severity).

Materials And Methods: Fifty patients with EM and fifty patients with ETTH diagnosed according to International Classification of Headache Disorders-II are included in the study.

Exploring regional differences in cyclist safety at roundabouts: A comparative study between the UK (based on Northumbria data) and Belgium.

The level of safety for cyclists at roundabouts may vary according to national differences not only in the design itself but also sociodemographic, cyclist and driver behaviour as well as environmental factors. This paper investigates the national influence on cyclist casualty severity at roundabouts by comparing the United Kingdom (using Northumbria as a representative sample) and Belgium. The data included speed limits, socio-demographic characteristics, environmental conditions and driver/cyclist behaviour-related contributory factors.

The efficacy of transversus abdominis plane block for post-operative analgesia after the cesarean section performed under general anesthesia.

Objective: Several methods are used to control the pain after cesarean operations. Recently, the transverse abdominis plane block (TAP) has been proposed to compensate for the problems developed by preexisting methods. In the present study, we compared the analgesic efficacy of the TAP block after caesarean section in a prospective, randomized, double-blinded controlled trial.

Cyclist casualty severity at roundabouts - To what extent do the geometric characteristics of roundabouts play a part?

Introduction: In general, priority junctions are converted into roundabouts to increase capacity and reduce vehicle accidents. However, previous research has indicated that roundabouts are dangerous for vulnerable users, especially cyclists.

Method: This paper investigates which design factors influence cyclist casualty severity at give way (non-signalized) roundabouts with mixed traffic, using the UK STATS19 National dataset of cyclist casualties.

Integrated Pulmonary Index (IPI) monitorization under sedation in cataract surgery with phacoemulsification technique.

Purpose: We aimed to investigate that change of IPI values after sedation of patients undergoing cataract surgery under sedation.

Methods: We included 50 patients (ASA I-III) undergoing cataract surgery under sedation by phacoemulsification method in this prospective observational study. IPI, SpO, ETCO, respiratory rate (RR), peripheral pulse rate (PR), hemodynamic data and BIS values and perioperative complications were recorded.

Prevalence and Angiographic Characteristics of Coronary Vasospasm Detected at Surveillance Coronary Angiograms Among Patients With Heart Transplants.

Objectives: Coronary vasospasm in heart transplant recipients occurs through various mechanisms. It has been linked to allograft rejection and coronary vasculopathy, which can result in mortality during follow-up. Here, we investigated the prevalence of coronary vasospasm among heart transplant recipients undergoing surveillance coronary angiography procedures.

Posttransplant Pulmonary Hypertension Is Correlated With Acute Rejection and Death Among Cardiac Transplant Recipients: A Single Center Study.

Objectives: Endomyocardial biopsy sampling is used to check acute rejection after cardiac transplant. However, it may lead to tricuspid valve injury and cardiac perforation; therefore, less invasive tools may be useful. Right heart catheterization provides valuable information about cardiac hemodynamics.

Investigation of possible maternal and fetal factors which affect umbilical coiling index.

Aim: The aim of this study was to investigate the possible maternal and fetal factors, which affect the Umbilical Coiling Index (UCI).

Methods: This prospective, observational, analytic study was conducted using the data of 380 women with term pregnancy and newborns who presented at a University Hospital. Hemoglobin (Hb), ferritin, iron, and the total iron binding capacity (TIBC) of the maternal blood were measured, and transferrin saturation was estimated based on the ratio between serum iron and TIBC.

Body Mass Index Effects Kruger's Criteria in Infertile Men.

Background: The aim of this study is to evaluate the relationship between sperm parameters and body mass index (BMI) in the male spouses with infertility complaints, who had reffered to our clinic.

Materials And Methods: The male spouses from 159 couples reffering to our clinic because of infertility, during a six-month period, were included in the study. In this prospective case control study, the included men were categorized as non-obese (BMIP<25 kg/m), overweight (BMI 25-29 kg/m) and obese (BMI ≥30 kg/m) according to their BMIs.

Chemokine (C-C motif) ligand-2 (CCL2) and oxidative stress markers in recurrent pregnancy loss and repeated implantation failure.

Purpose: The main purpose of this study is to evaluate the inflammatory response and oxidative stress together in the cases of recurrent pregnancy loss (RPL) and repeated implantation failure (RIF).

Methods: This is a cross-sectional study conducted to compare infertile patients who have RIF and patients with RPL histories in terms of CCL2, TAS, TOS, and OSI. To this end, two study groups were formed by primary-infertile women with RIF history and women with nulliparous RPL history who consulted a university hospital between 2014 and 2016, and a control group was formed by multiparous women who had no pregnancy loss.

Factors affecting pregnancy weight gain and relationships with maternal/fetal outcomes in Turkey.

To determine the effects of pre-pregnancy body mass index (BMI) and gestational weight gain on maternal and fetal complications, and to examine whether Turkish women achieve the recommended gestational weight gain. We also investigated the relationship between pregnancy weight gain and mode of delivery, with an examination of maternal anthropometry.  Methods: A retrospective cross-sectional study was conducted on a population of 986 pregnant women between November 2011 and November 2015 at Atatürk Education and Research Hospital, Ankara, Turkey.

[Analgesia Nociception Index for perioperative analgesia monitoring in spinal surgery].

Background And Objectives: The Analgesia Nociception Index is an index used to measure the levels of pain, sympathetic system activity and heart rate variability during general anesthesia. In our study, Analgesia Nociception Index monitoring in two groups who had undergone spinal stabilization surgery and were administered propofol-remifentanil (Total Intravenous Anesthesia) and sevoflurane-remifentanyl anesthesia was compared regarding its significance for prediction of postoperative early pain.

Methods: BIS and Analgesia Nociception Index monitoring were conducted in the patients together with standard monitoring.

Can soluble transferrin receptor be used in diagnosing iron deficiency anemia and assessing iron response in infants with moderate acute malnutrition?

Objective: To evaluate the efficacy of soluble transferrin receptor (sTfR) in diagnosing iron deficiency anemia (IDA) and evaluating iron response in infants with moderate acute malnutrition (MAM).

Population And Methods: Infants with hemoglobin (Hb) levels lower than threshold values for anemia for their ages and hypochromic/ microcytic anemia on peripheral smear were recruited. MAM was defined as weight/height z score < -2 to -3.

The relationship between postmenopausal women's sclerostin levels and their bone density, age, body mass index, hormonal status, and smoking and consumption of coffee and dairy products.

Purpose: To investigate the relationship between postmenopausal women's sclerostin levels and bone density and the factors that may affect this relationship.

Materials And Methods: 135 postmenopausal patients' ages, BMIs, hormonal statuses, BMD values, and smoking, and consumption of coffee and dairy products were compared with their sclerostin levels.

Results: No statistical relationship was found between sclerostin level and age in the group with osteoporosis (p = 0.

The incidence of pressure ulcer in patients on mechanical ventilation andeffects of selected risk factors on pressure ulcer development.

Background/aim: This study aimed to determine the incidence of pressure ulcers in patients on mechanical ventilation and selected risk factors likely to play a role in pressure ulcer development.

Materials And Methods: The study included 110 patients recruited from an anesthesia critical care unit of a university hospital. Data were collected with a demographic and clinical characteristics form.