Publications by authors named "Akemi Tanemoto"
Article Synopsis
- Ejaculated mammalian sperm undergo a maturation process called capacitation, necessary for fertilization, and proteins from the sPLA2 family are thought to play a crucial role in this process.
- Research found that mouse group X sPLA2 (mGX) is a key enzyme in the acrosome of sperm that gets activated during capacitation and is crucial for successful fertilization.
- mGX-deficient male mice showed reduced fertility, indicating that mGX enhances sperm function and helps eliminate less viable sperm, thereby improving overall fertilization rates.
Prostaglandin E synthase (PGES), which converts cyclooxygenase (COX)-derived prostaglandin H(2) (PGH(2)) to PGE(2), is known to comprise a group of at least three structurally and biologically distinct enzymes. Two of them are membrane-bound and have been designated as mPGES-1 and mPGES-2. mPGES-1 is a perinuclear protein that is markedly induced by proinflammatory stimuli and downregulated by anti-inflammatory glucocorticoids as in the case of COX-2.
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