Publications by authors named "Akemi Ishida Yamamoto"
Eczematous paradoxical reactions are commonly associated with anti-interleukin-17A (anti-IL-17A) antibodies. However, IL-23 p19 inhibitors can also cause similar cutaneous manifestations. We present a case of a 77-year-old Japanese woman with palmoplantar pustulosis (PPP), who developed eczematous lesions on her face, neck, and dorsum of the hands 10 weeks after initiating guselkumab treatment.
View Article and Find Full Text PDFVerrucous skin lesions in diabetic neuropathy (VSLDN) are rare and typically occur at weight-bearing sites due to chronic mechanical stress. This case report describes a 35-year-old man with type 2 diabetes mellitus who developed a verrucous lesion on the dorsum of his left foot following toe amputation and skin grafting. Histological analysis identified pseudoepitheliomatous hyperplasia with no evidence of malignancy or human papillomavirus infection.
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- The diagnosis of systemic amyloidosis typically involves detecting amyloid deposits in tissue samples, often taken from abdominal skin due to the non-invasive nature of the procedure.
- Various staining techniques, including Thioflavin T (ThT), Congo Red, and Direct Fast Scarlet (DFS), are used for visualization, but ThT can produce false-positive results when lipomembranous fat necrosis (LFN) is present.
- To avoid misdiagnosis, it's important to know that LFN can interfere with amyloid screening tests, hence skin samples should be taken from areas not affected by such changes and using multiple stains is advisable for more accurate results.
Background Psoriasis is a chronic inflammatory skin disease with multiple organ manifestations such as arthritis and cardiovascular diseases. While recent therapeutic advancements in systemic biologics have demonstrated efficacy against psoriasis, a complete cure has not been achieved and patients require lifelong treatment to control symptoms. Objective This study aimed to clarify the clinical characteristics of psoriasis patients treated with biologics at an extended interval.
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- Pseudo-Kaposi sarcoma (PKS) is a benign vascular condition resembling Kaposi's sarcoma, caused by arteriovenous malformation (AVM) and chronic venous insufficiency, characterized by reddish-brown papules and requiring histopathological differentiation for diagnosis.
- A case study presents an 83-year-old man with diabetes, who suffered from an ulcer on his second toe due to severe ischemia linked to an AVM and occlusion of the dorsalis pedis artery, resulting in a pathological diagnosis of PKS after skin biopsy.
- Although the initial ulcer healed, it recurred two years later, leading to infection; attempts to manage blood flow through procedures
Article Synopsis
- Autosomal recessive congenital ichthyoses (ARCI) is a genetic skin condition caused by mutations in at least 12 genes, primarily ABCA12, resulting in different types like congenital ichthyosiform erythroderma and lamellar ichthyosis.
- This study aimed to identify previously unknown pathogenic variants in ABCA12 and update the understanding of how these genetic changes affect patient symptoms.
- Researchers discovered 11 new ABCA12 variants and confirmed their impact through genetic sequencing, increasing the knowledge of disease severity and phenotypes associated with these genetic mutations in ichthyosis patients.
Recessive dystrophic epidermolysis bullosa (RDEB) is a genodermatosis caused by variants in COL7A1-encoded type VII collagen, a major component of anchoring fibrils. In this study, we developed an ex vivo gene therapy for RDEB using autologous mesenchymal stromal cells (MSCs). On the basis of our previous studies, we first attempted to isolate MSCs from the blister fluid of patients with RDEB and succeeded in obtaining cells with a set of MSC characteristics from all 10 patients.
View Article and Find Full Text PDFEvasion from immunity is a major obstacle to the achievement of successful cancer immunotherapy. Hybrids derived from cell-cell fusion are theoretically associated with tumor heterogeneity and progression by conferring novel properties on tumor cells, including drug resistance and metastatic capacity; however, their impact on immune evasion remains unknown. Here, we investigated the potency of tumor-macrophage hybrids in immune evasion.
View Article and Find Full Text PDFBackground/aim: Malignant melanoma is a fatal skin cancer and is among the most immunogenic malignancies expressing melanoma-differentiation antigens and neoantigens. SRY-related HMG-box 10 (SOX10) is a transcription factor and a neural-crest differentiation marker that is used as a diagnostic marker for melanoma whilst playing a role in melanoma initiation through activation of the SOX10-MITF axis. SOX10 was shown to play a role in melanoma initiation by inducing expression of immune checkpoint molecules (e.
View Article and Find Full Text PDFAutoimmune diseases triggered by coronavirus disease 2019 (COVID-19) mRNA vaccination have been emerging. Here, we report the case of a 27-year-old Japanese man with autoimmunity-related neutrophilic dermatosis, occurring as an initial cutaneous manifestation of systemic lupus erythematosus with Sjögren syndrome after the second dose of the Pfizer/BioNTech COVID-19 vaccination. The patient presented with urticarial erythema and partially annular erythema on the trunk and extremities with severe pruritus.
View Article and Find Full Text PDFThe formation of mature vasculature through angiogenesis is essential for adequate wound healing, such that blood-borne cells, nutrients, and oxygen can be delivered to the remodeling skin area. Neovessel maturation is highly dependent on the coordinated functions of vascular endothelial cells and perivascular cells, namely pericytes (PCs). However, the underlying mechanism for vascular maturation has not been completely elucidated, and its role in wound healing remains unclear.
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