Subungual Hematoma.

The authors present the case of a 64-year-old male who presented to the emergency department due to foot trauma. He sustained a large subungual hematoma, which was drained. Following the procedure, the patient achieved complete resolution of his pain.

Sickle cell disease promotes sex-dependent pathological bone loss through enhanced cathepsin proteolytic activity in mice.

Sickle cell disease (SCD) is the most common hereditary blood disorder in the United States. SCD is frequently associated with osteonecrosis, osteoporosis, osteopenia, and other bone-related complications such as vaso-occlusive pain, ischemic damage, osteomyelitis, and bone marrow hyperplasia known as sickle bone disease (SBD). Previous SBD models have failed to distinguish the age- and sex-specific characteristics of bone morphometry.

Classifying Multi-Level Stress Responses From Brain Cortical EEG in Nurses and Non-Health Professionals Using Machine Learning Auto Encoder.

Objective: Mental stress is a major problem in our society and has become an area of interest for many psychiatric researchers. One primary research focus area is the identification of bio-markers that not only identify stress but also predict the conditions (or tasks) that cause stress. Electroencephalograms (EEGs) have been used for a long time to study and identify bio-markers.

Machine learning algorithms for predicting coronary artery disease: efforts toward an open source solution.

Aim: The development of coronary artery disease (CAD), a highly prevalent disease worldwide, is influenced by several modifiable risk factors. Predictive models built using machine learning (ML) algorithms may assist clinicians in timely detection of CAD and may improve outcomes.

Materials & Methods: In this study, we applied six different ML algorithms to predict the presence of CAD amongst patients listed in 'the Cleveland dataset.

Modulation of Brain Pathology by Enhancer RNAs in Cerebral Ischemia.

Recent studies have reported widespread stimulus-dependent transcription of mammalian enhancers into noncoding enhancer RNAs (eRNAs), some of which have central roles in the enhancer-mediated induction of target genes and modulation of phenotypic outcomes during development and disease. In cerebral ischemia, the expression and functions of eRNAs are virtually unknown. Here, we applied genome-wide H3K27ac ChIP-seq and genome-wide RNA-seq to identify enhancer elements and stroke-induced eRNAs, respectively, in the mouse cerebral cortex during transient focal ischemia.

Long Noncoding RNAs in the Pathophysiology of Ischemic Stroke.

Ischemic stroke is an acute brain injury with high mortality and disability rates worldwide. The pathophysiological effects of ischemic stroke are driven by a multitude of complex molecular and cellular interactions that ultimately result in brain damage and neurological dysfunction. The Human Genome Project revealed that the vast majority of the human genome (and mammalian genome in general) is transcribed into noncoding RNAs.

Captopril augments acetylcholine-induced bronchial smooth muscle contractions in vitro via kinin-dependent mechanisms.

Angiotensin converting enzyme (ACE) inhibitors therapy is aassociated with bothersome dry cough as an adverse effect. The mechanisms underlying this adverse effect are not clear. Therefore, influence of captopril (an ACE inhibitor) on acetylcholine (ACh)-induced bronchial smooth muscle contractions was investigated.

Morphine blocks the Mesobuthus tamulus venom-induced augmentation of phenyldiguanide reflex and pulmonary edema in anesthetized rats.

Objective: Pulmonary edema, a manifestation of scorpion envenomation syndrome, is attributed to cardiogenic or noncardiogenic factors. Morphine is a drug used for cardiogenic pulmonary edema and its effect on Mesobuthus tamulus (MBT) venom-induced changes is not known. Therefore, we hypothesized that morphine blocks the MBT venom-induced augmentation of phenyldiguanide (PDG) reflex and pulmonary edema.

Reflex hypertensive response induced by capsaicin involves endothelin-dependent mechanisms.

Capsaicin, a nociceptive agent produces triphasic pressure response in rats. The mechanisms underlying capsaicin-induced pressure responses are not clear. Therefore, the present study was undertaken to determine the mechanisms involved in capsaicin - induced pressure responses.

Vagal efferent stimulation protects against Mesobuthus tamulus venom-induced acute respiratory distress syndrome in rats.

Mesobuthus tamulus (MBT) venom and oleic acid (OA) have been shown to produce acute respiratory distress syndrome (ARDS) involving different mechanisms. The role of vagally mediated anti-inflammatory pathway in ARDS is poorly understood. Therefore, the effects of vagal efferent stimulation on these two models of ARDS were examined.

Pulmonary oedema producing toxin from Mesobuthus tamulus venom augments cardio-respiratory reflexes through B2 kinin receptors.

The current study was undertaken to compare the effects of pulmonary oedema producing toxin (PO-Tx) isolated from Mesobuthus tamulus venom on cardio-respiratory reflexes with exogenously administered bradykinin (BK) and to delineate the type of BK receptors mediating these responses. Jugular venous injection of phenyldiguanide (PDG) in anaesthetized rats produced reflex bradycardia, hypotension and apnoea. The PDG-induced reflex was augmented (two folds) by PO-Tx.

Mesobuthus tamulus venom induces acute respiratory distress syndrome in rats involving additional mechanisms as compared to oleic acid model.

The present study was undertaken to determine whether acute respiratory distress syndrome (ARDS) is produced after Mesobuthus tamulus (MBT) envenomation and compared it with oleic acid (OA)-induced ARDS. The trachea, jugular vein and femoral artery were cannulated in anesthetized adult rats. Lethal dose of MBT venom (5 mg/kg) or OA (75 μL) was administered intravenously and the time-dependent changes in respiratory frequency (RF), heart rate (HR) and mean arterial pressure (MAP) were recorded.

Characterization of oleic acid-induced acute respiratory distress syndrome model in rat.

Animal studies using oleic acid (OA) model to produce acute respiratory distress syndrome (ARDS) have been inconsistent. Therefore, the present study was undertaken to establish an acute model of ARDS in rats using OA and to characterize its effect on cardio-respiratory parameters and lethality. The trachea, jugular vein and femoral artery of anesthetized adult rats were cannulated.

A simulation based case study for control of DSTATCOM.

This paper presents a distribution static compensator (DSTATCOM) for power quality improvements in terms of harmonics and power factor correction in a three-phase four-wire distribution system. The DSTATCOM is implemented with PWM current controlled six-leg voltage source converter (VSC) and the switching patterns are generated through a novel synchronous reference frame controller (SRFC). The insulated gate bipolar transistor (IGBT) based VSC is supported by a capacitor and is controlled for the required compensation of the load current.

A study to investigate capsaicin-induced pressure response in vagotomized rats.

Objectives: Capsaicin is used to evoke pulmonary C reflexes and produces complex pressure responses along with apnea/tachypnea, and bradycardia. In the present study, the mechanisms involved in capsaicin-induced pressure responses were explored.

Materials And Methods: Tracheal, jugular venous, and femoral artery cannulations were performed in anesthetized adult rats.

Pulmonary surfactants and their role in pathophysiology of lung disorders.

Surfactant is an agent that decreases the surface tension between two media. The surface tension between gaseous-aqueous interphase in the lungs is decreased by the presence of a thin layer of fluid known as pulmonary surfactant. The pulmonary surfactant is produced by the alveolar type-II (AT-II) cells of the lungs.

Mechanisms underlying the augmentation of phenylbiguanide and capsaicin induced cardiorespiratory reflexes by Mesobuthus tamulus venom.

Phenylbiguanide (PBG) and capsaicin evoke cardiorespiratory reflexes utilizing two separate pathways. It is known that Indian Red Scorpion (Mesobuthus tumulus; MBT) venom augments PBG (5-HT(3)) responses but, the effect of MBT venom on capsaicin (TRPV1)-induced response is not known. Therefore, the present study was undertaken to ascertain whether MBT venom also augments the capsaicin-induced reflex responses involving mechanisms similar to PBG.

Digital holographic storage system incorporating optical fixing.

Digital holograms have been written in stoichiometric Pr:LiNbO(3) in a two-color recording scheme, demonstrating what is to our knowledge the first all-optical nondestructive readout of digital data. Using writing light at 800nm and gating light at 476 nm, we stored and retrieved 256-kbit digital data pages with a raw bit-error rate BER of <10(-4) .

One-color one-beam pumping of Er(3+)-doped ZBLAN glasses for a three-dimensional two-step excitation display.

We demonstrate a one-color one-beam pumping method for a three-dimensional two-step excitation fluorescent display with Er(3+) -doped ZBLAN glass. A localized green fluorescent spot is obtained by use of a focused pump-light beam at 979 nm. The quantum efficiency of the two-step excitation fluorescence is investigated in a time-dependent analysis and an experiment with a pulsed pump light.

Photorefractive materials for nonvolatile volume holographic data storage.

Optically gated recording and nonvolatile readout in a digital volume holographic data storage system that uses a pair of mutually incoherent light sources during recording and only one for readout were demonstrated recently. This approach used stoichiometric lithium niobate, which after post-growth processing gave rise to an at least two orders of magnitude improvement in sensitivity over the best materials reported previously. It is also shown that by adding certain dopants (iron and manganese) to near-stoichiometric lithium niobate, the dark storage time and gating efficiency can be increased compared with previous work.

Two-photon holographic recording in aluminosilicate glass containing silver particles.

Recording of holographic gratings by 532-nm laser pulses in photochromic bulk aluminosilicate glass containing silver particles is demonstrated. A diffraction efficiency of 1.5% is achieved for readout at the same wavelength.

Synthesis and characterization of photochromic organic films for holographic recording.

Polymer films doped with 2-(5, 5-dimethyl-3-styryl-cyclohex-2-enylidene)-malononitrile chromophore and various sensitizers have been prepared and characterized. The material exhibits high sensitivity in the red region (S=0.26 cm(2)/J at lambda=633 nm), a large dynamic range (Dn=-0.