Publications by authors named "Akeem Ayodeji Okesina"

Article Synopsis
  • - The study investigates how thymoquinone can protect the brain from damage caused by the insecticide cypermethrin, focusing on its effects within the dentate gyrus region responsible for memory and motor functions.
  • - Forty adult male rats were divided into five groups, receiving various treatments over 14 days, including combinations of cypermethrin and thymoquinone, followed by tests to assess memory and brain health.
  • - Results indicate that thymoquinone improves memory performance and supports brain cell integrity while reducing neurotoxic effects of cypermethrin, suggesting its potential as a treatment for pesticide-related neurotoxicity.
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Background: Hypertension remains a major global health challenge, including in low- and middle-income countries. In Rwanda, a lack of adequate information and healthcare services impacts healthcare-seeking behaviors, contributing to undiagnosed hypertension in rural areas. Therefore, the need to determine its prevalence and associated factors.

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Type 2 diabetes mellitus (T2DM), characterized by insulin resistance and glucose dysmetabolism, is a major metabolic disorder accompanied with health and financial burden. Recently, research findings showed that orange peel extract (OPE) has health benefits such as improved insulin sensitivity and glucose metabolism. The present study aimed at establishing the role of naringin from OPE on T2DM-induced glucose and lipid dysmetabolism.

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Article Synopsis
  • Type 2 diabetes mellitus (T2DM) can negatively impact testicular function, and this study aimed to examine the effects of naringin, a compound from orange peel, on T2DM-related testicular dysfunction in male Wistar rats.
  • The results showed that naringin reduced high blood sugar levels and improved sperm quality, hormones, and antioxidant capacity, while also decreasing markers of oxidative stress and inflammation.
  • The findings suggest that naringin could be a beneficial supplement for addressing male infertility caused by T2DM, even though oral orange peel extract had a more pronounced effect.
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Over time, the use of plant-derived agents in the management of various human health conditions has gained a lot of attention. The study assessed the hepatoprotective potential of ethyl acetate fraction leaves (EFTI) during prenatal aluminum chloride exposure. Pregnant rats were divided into 5 groups (n = 4); Group I rats were administered 2 ml kg of distilled water (negative control), Group II rats received only 200 mg kg aluminum chloride (positive control), Group III rats were administered 200 mg kg aluminum chloride and 400 mg kg EFTI, Group IV rats were administered 200 mg kg aluminum chloride and 800 mg kg EFTI, Group V rats were administered 200 mg kg aluminum chloride and 300 mg kg Vit E (comparative control).

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Alzheimer's disease (AD) is the most common cause of dementia worldwide. Because Alzheimer's disease has no known treatment, sufferers and their caregivers must concentrate on symptom management. Astrocytes and microglia are now known to play distinct physiological roles in synaptic function, the blood-brain barrier, and neurovascular coupling.

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Purpose: The recent increase in aluminum exposure and its effect on the development of the brain call for serious attention. The study investigated the behavioral and immunohistochemical changes in the cerebral cortex of Wistar rats following prenatal co-administration of ethyl acetate leaf fraction of (EATI) and aluminum chloride (AlCl).

Methods: Pregnant Wistar rats were divided into 5 groups (n=4).

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Alcohol exposure to the cerebellum has been known to trigger cerebellar dysfunctions through several mechanisms. This present study was designed to evaluate the repealing effect of D-ribose-L-cysteine (DRLC) on alcohol-induced cerebellar dysfunctions in juvenile BALB/c mice. The animals were randomly divided into 4 groups (=10 per group).

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Despite reports that quinoline antimalarials including chloroquine (Chq) exhibit idiosyncratic neuropsychiatric effects even at low doses, the drug continues to be in widespread use during pregnancy. Surprisingly, very few studies have examined the potential neurotoxic action of Chq exposure at different points of gestation or how this phenomenon may affect neurophysiological well-being in later life. We therefore studied behavior, and the expression of specific genes and neurochemicals modulating crucial neural processes in offspring of rats exposed to prophylactic dose of Chq during different stages of gestation.

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