Characterization of as a Potential Prognostic Marker of Oncological Diseases.

The main goal of this study is to consider as a potential prognostic marker of oncological diseases using the mutational, expression, and survival data of cancer studies which are publicly available online. We collected data from four databases (cBioPortal, The Cancer Genome Atlas; cBioPortal, Genie; International Cancer Genome Consortium; ArrayExpress). In total, 111,283 samples were categorized according to 27 tumor locations.

[Molecular dynamics of immune complex of photoadduct-containing DNA with Fab-Anti-DNA antibody fragment].

Antibodies to DNA play an important role in the pathogenesis of autoimmune diseases. The elucidation of structural mechanisms of both the antigen recognition and the interaction of anti-DNA antibodies with DNA will help to understand the role of DNA-containing immune complexes in various pathologies and can provide a basis for new treatment modalities. Moreover, the DNA-antibody complex is an analog of specific intracellular DNA-protein interactions.

An anti-DNA antibody prefers damaged dsDNA over native.

DNA-protein interactions, including DNA-antibody complexes, have both fundamental and practical significance. In particular, antibodies against double-stranded DNA play an important role in the pathogenesis of autoimmune diseases. Elucidation of structural mechanisms of an antigen recognition and interaction of anti-DNA antibodies provides a basis for understanding the role of DNA-containing immune complexes in human pathologies and for new treatments.

[Peculiarities of genotype distribution of interleukins (IL-1 and IL-10) in patients with peptic ulcer disease and their associations with persistence of Mycoplasma hyorhinis and Helicobacter pylori genotypes].

It was found for the first time in our study that there is a significant prevalence of combinations of IL-1 and IL-10 genotypes--IL-1B-511C/C, IL-1B+3954C/C, IL-1RN1/1, IL-10-1082A/A and IL-1B-511T/C, IL-1B+3954C/C, IL-1RN1/2, IL-10- 1082A/G--in the group of patients with gastric and duodenal ulcer disease and control one, respectively. The correlation between the Tox- (cagA- vacAs1-) strains of H. pylori and the combinations of genotypes IL-1B-511T/C, IL-1B +3954C/C, IL-1RN1/1, IL-10-1082G/G was shown (p <0,05).