The relationship between fatigue levels and psychosocial adjustment in elderly individuals with chronic obstructive pulmonary disease: A descriptive study.

Background: Chronic Obstructive Pulmonary Disease (COPD) is associated with physical limitations and significant social, psychological, and behavioral challenges. This study investigates the relationship between fatigue levels and psychosocial adjustment in COPD patients, considering their sociodemographic characteristics.

Methods: A descriptive study was conducted with 160 COPD patients hospitalized in the Pulmonology Department of a university hospital.

Evaluation of balance in children with hemophilia and the effect of balance on quality of life.

Background: Repeated joint bleeds are reported to decrease static balance in children with hemophilia (CwH).

Research Question: Is dynamic balance affected in CwH? Does dynamic balance affect the quality of life in these patients?

Methods: This cross-sectional study included thirty male children aged 7-18 years diagnosed with hemophilia, along with thirty healthy male children as controls. Dynamic balance was evaluated using the limits of stability (LOS) test and a fall risk test, both conducted via the Biodex Balance System.

Correction: Investigation of RhoA, ROCK1, and ROCK2 Gene Expressions in Autism Spectrum Disorders.

[This corrects the article DOI: 10.7759/cureus.74810.

Investigation of RhoA, ROCK1, and ROCK2 Gene Expressions in Autism Spectrum Disorders.

Objective: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that emerges in early childhood and is characterized by difficulties in social communication, repetitive behaviors, and restricted interests. The Ras homolog (Rho)/Rho-kinase signaling pathway plays a critical role in maintaining synaptic structure and function, as it regulates the actin cytoskeleton. This study aims to investigate the expression of the Ras homolog (Rho) family member A (), Rho-kinase 1 (), and Rho-kinase 2 () genes within this pathway in relation to ASD.

Brain networks and intelligence: A graph neural network based approach to resting state fMRI data.

Resting-state functional magnetic resonance imaging (rsfMRI) is a powerful tool for investigating the relationship between brain function and cognitive processes as it allows for the functional organization of the brain to be captured without relying on a specific task or stimuli. In this paper, we present a novel modeling architecture called BrainRGIN for predicting intelligence (fluid, crystallized and total intelligence) using graph neural networks on rsfMRI derived static functional network connectivity matrices. Extending from the existing graph convolution networks, our approach incorporates a clustering-based embedding and graph isomorphism network in the graph convolutional layer to reflect the nature of the brain sub-network organization and efficient network expression, in combination with TopK pooling and attention-based readout functions.

The impact of malignancy on death anxiety and psychological well-being in middle-aged and older patients undergoing abdominal surgery: a quasi-experimental study.

Background: Malignancy is a critical factor affecting death anxiety and psychological well-being. This study examined the impact of malignancy on death anxiety and psychological well-being in middle-aged and older adult patients undergoing abdominal surgery and projected it along with sociodemographic profiles.

Methods: This study is quasi-experimental in design.

Utilising Narrative Medicine to Identify Key Factors Affecting Quality of Life in Dry Eye Disease: An Italian Multicentre Study.

Introduction: Despite an improved understanding of its pathogenesis, dry eye disease (DED) remains relatively underestimated and its treatment challenging. A better alignment between the clinical evaluation and the patient self-assessment also requires capturing the whole patient experience of DED. This project aimed to unveil this experience through narrative medicine (NM).

The effect of digital game addiction on aggression and anger levels in adolescents: A cross-sectional study.

Purpose: In this study, it was aimed to determine the effect of digital game addiction on aggression and anger levels in adolescents.

Design And Methods: The participants of this cross-sectional study were adolescents. Data were collected using a socio-demographic questionnaire, Game Addiction Scale, and Buss-Perry Aggression Scale.

Analysis of amputations occurring in the earthquakes centered in Kahramanmaraş: Adıyaman experience.

Purpose: Amputations are a common surgical procedure resulting from trauma during earthquakes, leading to severe disability. This study aims to investigate surgical outcomes specific to amputations that occurred in Adıyaman after the Kahramanmaraş earthquakes.

Methods: This descriptive study included amputees who presented to Adıyaman University Training and Research Hospital.

DDI Prediction With Heterogeneous Information Network - Meta-Path Based Approach.

Drug-drug interaction (DDI) indicates where a particular drug's desired course of action is modified when taken with other drug (s). DDIs may hamper, enhance, or reduce the expected effect of either drug or, in the worst possible scenario, cause an adverse side effect. While it is crucial to identify drug-drug interactions, it is quite impossible to detect all possible DDIs for a new drug during the clinical trial.

Clinical and Laboratory Characteristics of MODY Cases, Genetic Mutation Spectrum and Phenotype-genotype Relationship.

Objective: Maturity onset diabetes of the young (MODY) occurs due to mutations in genes involved in pancreatic beta cell function and insulin secretion, has heterogeneous clinical and laboratory features, and account for 1-5% of all diabetes cases. The prevalence and distribution of MODY subtypes vary between countries. The aim of this study was to evaluate the clinical and laboratory characteristics, mutation distribution, and phenotype-genotype relationship in a large case series of pediatric Turkish patients genetically diagnosed with MODY.

Brain Networks and Intelligence: A Graph Neural Network Based Approach to Resting State fMRI Data.

Resting-state functional magnetic resonance imaging (rsfMRI) is a powerful tool for investigating the relationship between brain function and cognitive processes as it allows for the functional organization of the brain to be captured without relying on a specific task or stimuli. In this paper, we present a novel modeling architecture called BrainRGIN for predicting intelligence (fluid, crystallized and total intelligence) using graph neural networks on rsfMRI derived static functional network connectivity matrices. Extending from the existing graph convolution networks, our approach incorporates a clustering-based embedding and graph isomorphism network in the graph convolutional layer to reflect the nature of the brain sub-network organization and efficient network expression, in combination with TopK pooling and attention-based readout functions.

Effect of felodipine on indomethacin-induced gastric ulcers in rats.

Felodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties. Researchers have stated that oxidative stress and inflammation also play a role in the pathophysiology of gastric ulcers caused by nonsteroidal anti-inflammatory drugs. The aim of this study was to investigate the antiulcer effect of felodipine on indomethacin-induced gastric ulcers in Wistar rats and compare it with that of famotidine.

Reversible Severe Parkinsonism Caused by Extra-Pontine Myelinolysis in a patient with Primary Adrenal Failure.

Purpose: Extrapontine myelinolysis (EPM) is a highly uncommon, life-threatening disease, particularly in individuals who initially appear with severe clinical symptoms. Here, we describe a case of EPM caused by the rapid correction of hyponatremia that had severe clinical signs at first but parkinsonism symptoms were fully improved after treatment.

Case Report: A 46-year-old female patient was admitted to the hospital due to impaired consciousness.

Spatial and temporal variation of meteorological parameters in the lower Tigris-Euphrates basin, Türkiye: application of non-parametric methods and an innovative trend approach.

In this study, Mann-Kendall (MK), Spearman's rho (SR), and innovative trend analysis with significance test (ITA-ST) are performed on about 53 years of meteorological parameters obtained from 23 meteorological stations located in the lower Tigris-Euphrates basin (LTEB), Türkiye. Finally, sequential Mann-Kendall (SMK) and Cusum tests are applied to detect any abrupt changes in annual time series. Results indicate that MK and SR demonstrate a significant trend in seven of the total annual precipitation series, and ITA-ST captures the existence of a significant trend in 21 of the 23 total annual precipitations.

Head posture mediates the association of cognition with hand grip and pinch strength in older adults: an examination using structural equation modeling.

Background: The association of cognition with hand grip and pinch strength has been well-recognized in older adults. The authors sought to explore: (1) associations among forward head posture (FHP), cognition, and hand grip and pinch strength in older adults; and (2) the mediator role of FHP in these pathways using structural equation modeling (SEM).

Methods: This cross-sectional study included 88 older adults (70.

The effect of spiritual well-being on compassion fatigue among intensive care nurses: A descriptive study.

Objectives: This study aimed to determine the effect of spiritual well-being of intensive care nurses on compassion fatigue.

Methods: It is a descriptive study. The sample of the study was composed of 167 nurses who were working in the intensive care units of the hospitals in Turkey.

Physiological aspect of apoptosis-regulating microRNAs expressions during fasting.

Objective: Fasting is an activity that requires a certain calorie restriction without consuming food or drinks for a certain period of daytime. However, fasting triggers many complex events, including activating cellular stress response pathways, autophagy promotion, apoptosis pathways, and a change in hormonal balance. Among the many events affecting the regulation of apoptosis, the expression of microRNAs (miRNAs) plays an important role.

The Effects of Sunitinib in Healthy and Cisplatin-Induced Rats.

Sunitinib is a multitargeted kinase inhibitor that inhibits many receptor tyrosine kinases and has been used in the treatment of gastrointestinal stromal tumors, metastatic renal cell carcinoma, and pancreatic neuroendocrine tumors. In this study, the effects of sunitinib given to rats, both alone and after stress with cisplatin, were investigated. The animals were divided into four groups - (1) control group (C) administered interperitoneally with a single dose 0.

Effect of adenosine triphosphate on ribociclib-induced skin toxicity in rats.

Purpose: Ribociclib is a CDK4/6 inhibitor approved for the treatment of breast cancer; it inhibits the activity of CDK4/6 by competitively binding to adenosine 5'-triphosphate (ATP) binding sites. Although generally well-tolerated, ribociclib has been connected to a number of serious dermatologic complications. This study explored the effects of ATP on ribociclib-induced skin damage.

The effect of solution-focused approach on anger management and violent behavior in adolescents: A randomized controlled trial.

Background: This study was carried out to evaluate the effect of a solution-focused approach on anger management and violent behavior in adolescents.

Method: The study was an experimental and randomized controlled trial including pre-test and post-test measurements and control group. The sample of experimental (n = 24) and control groups (n = 24) of the study consisted of 48 students.

The effects of sorafenib in healthy and cisplatin-treated rats.

Background: Sorafenib is a multikinase inhibitor currently used in the treatment of hepatocellular carcinoma, renal cell carcinoma and thyroid cancer.

Objectives: The literature on this agent is scarce. This study aimed to evaluate the effects of sorafenib when administered to both healthy and cisplatin-induced rats.