Publications by authors named "Akbar Muhammed Shahid"
Article Synopsis
- * A new technique called polymerase error rate sequencing (PER-seq) was developed to measure DNA polymerase error rates, revealing that a common Pol ε mutant (P286R) significantly increases CpG>TpG errors similar to those seen in cancer tumors.
- * Wild-type Pol ε shows a much higher error rate when replicating 5mCpG as opposed to regular cytosines, indicating that replication errors represent a crucial factor in CpG>TpG mutagenesis and altering the
Acute myeloid leukemia (AML) stem cells are required for the initiation and maintenance of the disease. Activation of the Wnt/β-catenin pathway is required for the survival and development of AML leukaemia stem cells (LSCs) and therefore, targeting β-catenin is a potential therapeutic strategy. NUC-7738, a phosphoramidate transformation of 3'-deoxyadenosine (3'-dA) monophosphate, is specifically designed to generate the active anti-cancer metabolite 3'-deoxyadenosine triphosphate (3'-dATP) intracellularly, bypassing key limitations of breakdown, transport, and activation.
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