Nitrogen Doped Carbon Quantum Dots as Fluorescence "Turn-Off-On" Sensor for Detection of Fe Ions and Ascorbic Acid in Moringa oleifera and Citrus Lemon.

In recent year, the uses of carbon quantum dots (CQDs) have increased in many fields. Herein we report, synthesis of fluorescent nitrogen doped carbon quantum dots (N-CQDs) by simple and ecofriendly hydrothermal method. The as-synthesized N-CQDs were characterized by various techniques and the quantum yield was also calculated.

Inner-filter effect of nitrogen-doped carbon quantum dots-MnO nanotubes for smartphone-integrated dual-mode sensing of glutathione and captopril.

Nitrogen-doped carbon quantum dots (N-CQDs) exhibit unique fluorescence properties and are considered one of the best candidates for the development of fluorescence-based sensors for the detection of many analytes. In this work, a smartphone-assisted fluorescent sensor has been developed using N-CQDs and MnO nanotubes (MnO NTs) for the detection of glutathione (GSH) and captopril (CAP). N-CQDs were facilely synthesized the solvothermal method, where -phenylenediamine (-PD) and urea were used as nitrogen precursors.

An innate pathogen sensing strategy involving ubiquitination of bacterial surface proteins.

Sensing of pathogens by ubiquitination is a critical arm of cellular immunity. However, universal ubiquitination targets on microbes remain unidentified. Here, using in vitro, ex vivo, and in vivo studies, we identify the first protein-based ubiquitination substrates on phylogenetically diverse bacteria by unveiling a strategy that uses recognition of degron-like motifs.

Differential Ubiquitination as an Effective Strategy Employed by the Blood-Brain Barrier for Prevention of Bacterial Transcytosis.

The protective mechanisms of blood-brain barrier (BBB) prohibiting entry of pathogens into central nervous system (CNS) are critical for maintenance of brain homeostasis. These include various intracellular defense mechanisms that are vital to block transcytosis of neurotropic pathogens into the CNS. However, mechanistic details of coordination between these defense pathways remain unexplored.

Impaired quality of life in growth hormone-deficient adults is independent of the altered skeletal muscle oxidative metabolism found in conditions with peripheral fatigue.

Context: Growth hormone-deficient (GHD) adults often report impaired quality of life (QoL) - with fatigue, a key element. This deficit can improve following GH replacement. The basis of this response is unclear.

Graves' immune reconstitution inflammatory syndrome in childhood.

Background: The use of hematopoietic stem cell transplantations (HSCTs) as a curative therapy for life-threatening immunodeficiencies has had a profound impact on clinical outcomes. A subset of patients may experience immune reconstitution inflammatory syndrome (IRIS) post-transplant affecting the thyroid gland, but this has received little attention in the pediatric literature. We present the clinical, biochemical, and cytological course of patients with Graves' disease after HSCT in the pediatric population.

Improving the vitamin D status of vitamin D deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle.

Objective: Suboptimal mitochondrial function has been implicated in several disorders in which fatigue is a prominent feature. Vitamin D deficiency is a well-recognized cause of fatigue and myopathy. The aim of this study was to examine the effects of cholecalciferol therapy on skeletal mitochondrial oxidative function in symptomatic, vitamin D-deficient individuals.

Prevention and treatment of vitamin D deficiency.

Vitamin D insufficiency and deficiency are widespread in many countries. We review the evidence pertaining to its prevention and treatment. Deficiency may be adequately treated with many different therapeutic regimens of either cholecalciferol or ergocalciferol, owing to the high therapeutic index of both compounds.

Vitamin D status in paediatric patients with cancer.

Background: Children with malignant disease are at increased risk of bone disorders and cardiovascular disease. Vitamin D status may influence this risk and so we assessed vitamin D levels in children with malignant disease undergoing active treatment or surveillance post-therapy.

Procedure: This was an outpatient-based cross-sectional study of 61 children with a history of malignancy (median age 11.