NAD Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy.

Background: Diabetes is a risk factor for heart failure and promotes cardiac dysfunction. Diabetic tissues are associated with nicotinamide adenine dinucleotide (NAD) redox imbalance; however, the hypothesis that NAD redox imbalance causes diabetic cardiomyopathy has not been tested. This investigation used mouse models with altered NAD redox balance to test this hypothesis.