Publications by authors named "Akari Momozono"
Objective: There is a high risk of asymptomatic hypoglycemia associated with hemodialysis (HD) using glucose-free dialysate; therefore, the inclusion of glucose in the dialysate is believed to prevent intradialytic hypoglycemia. However, the exact glycemic fluctuation profiles and frequency of asymptomatic hypoglycemia using dialysates containing >100 mg/dL glucose have not been determined.
Research Design And Methods: We evaluated the glycemic profiles of 98 patients, 68 of whom were men, with type 2 diabetes undergoing HD (HbA 6.
Numerous studies have shown that growth hormone (GH) replacement in adult GH deficiency (AGHD) improves the body composition and metabolic rate; however, data about the relationship between body composition and energy expenditure in these patients is scarce. Our study aimed to investigate the changes in resting energy expenditure (REE) and body composition after GH replacement in patients with AGHD. We enrolled 15 patients diagnosed with AGHD and evaluated the effect of GH replacement administered once daily for 12 months on REE, body composition measured by bioelectrical impedance analysis, and serological markers.
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- Oxidative stress is linked to chronic diseases, prompting research for clinical biomarkers to measure its severity, specifically focusing on the oxidation of Met (methionine) residues in serum albumin.
- The study utilized liquid chromatography-high resolution mass spectrometry (LC-MS) to quantify oxidised and non-oxidised Met, revealing higher levels in diabetic patients compared to controls; the GA/HbA ratio was found to independently impact Met oxidation.
- Findings also indicated that glycaemic variability, particularly hypoglycaemia and hyperglycaemia, correlates with increased Met oxidation, alongside associations with renal function and cholesterol levels, suggesting potential use of LC-MS quantification to assess oxidative stress in diabetes.
Glucose-dependent insulinotropic polypeptide (GIP), secreted from enteroendocrine K cells, has potent insulin-releasing and extrapancreatic glucoregulatory activities. However, exogenous GIP has less potent biological effects compared with another incretin hormone, GLP-1, which limits its use for the treatment of type 2 diabetes. The fate and secretion of administered native GIP remain unclear.
View Article and Find Full Text PDFOxidative stress contributes to the pathophysiology of a variety of diseases, and circulating biomarkers of its severity remains a topic of great interest for researchers. Our peptidomic strategy enables accurate and reproducible analysis of circulating proteins/peptides with or without post-translational modifications. Conventional wisdom holds that hydrophobic methionines exposed to an aqueous environment or experimental handling procedures are vulnerable to oxidation.
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