Mutation spectra of the BRCA1/2 genes in human breast and ovarian cancer and germline.

Annotating genomic sequence alterations is sometimes a difficult decision, particularly in missense variants with uncertain pathogenic significance and also in those presumed as germline pathogenic variants. We here suggest that mutation spectrum may also be useful for judging them. From the public databases, 982 BRCA1/1861 BRCA2 germline missense variants and 294 BRCA1/420 BRCA2 somatic missense variants were obtained.

Silicon Optical Modulator Using a Low-Loss Phase Shifter Based on a Multimode Interference Waveguide.

We have developed a novel phase modulator, based on fin-type electrodes placed at self-imaging positions of a silicon multimode interference (MMI) waveguide, which allows reduced scattering losses and relaxes the fabrication tolerance. The measured propagation losses and spectral bandwidth are 0.7 dB and 33 nm, respectively, on a 987 μm-long phase shifter.

Demonstration of a new optical scanner using silicon photonics integrated circuit.

The reliability and small size of solid state scanners makes them ideal for LIDAR. We fabricated and demonstrated the successful operation of an optical scanner using silicon photonics integrated circuit technology. The scanner comprises a ring resonator multiplexer and a number of grating arrays, and employs a beam switching method, which means that the scanner is movement-free.

Light-induced self-written waveguide fabrication using 1550 nm laser light.

Light-induced self-written (LISW) optical waveguides were fabricated for the first time, to the best of our knowledge, using a photopolymerizable resin system formed by 1550 nm pulse laser light. A two-photon absorption (TPA) chromophore with a TPA cross section of several hundred Goeppert-Mayer (GM) at 1550 nm was used. Furthermore, the optical interconnection between a single-mode fiber and a fiber Bragg grating was demonstrated by the present technique, using one-way irradiation of 1550 nm laser light through the single-mode fiber.

Polymer waveguide module for visible wavelength division multiplexing plastic optical fiber communication.

We report a polymer waveguide module that provides bidirectional communication over a single plastic optical fiber (POF) with dual visible wavelength LEDs. The module is constructed using light-induced self-written waveguides, which enables a three-dimensional optical circuit for visible wavelength division multiplexing to be fabricated by an extremely simple process. We demonstrated 250 Mbits/s communication using a pair of these modules that each contained one green (lambda = 495 nm) and one red (lambda = 650 nm) LEDs by measuring the bit error rates.