Publications by authors named "Akanksha Dahifale"
Glioblastoma multiforme (GBM) is considered to be one of the most devastating brain tumors with a shorter life expectancy. Several factors contribute to the dismal prognosis of GBM patients including the complicated nature of GBM, the ability of tumor cells to resist treatment, and the difficulty of delivering drugs to the brain because of barriers like the blood-brain barrier (BBB) and blood-tumor barrier (BTB). The unique challenges posed by the BBB in delivering therapeutic agents to the brain have led to the development of innovative nanotechnology-based approaches.
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- Glioblastoma (GB) is a highly aggressive brain tumor with poor treatment options and low survival rates, leading to a need for innovative drug delivery methods.
- This study focuses on creating triphenylphosphonium (TPP)-conjugated chitosan nanoparticles to effectively deliver temozolomide (TMZ) specifically to GB cells, using a Quality-by-Design approach for development.
- The optimized nanoparticles showed favorable characteristics, including a small size and high drug entrapment efficiency, while demonstrating improved retention in the nasal mucosa and enhanced cytotoxic effects compared to TMZ alone.