Evaluation of In Situ Hardening β-Tricalcium Phosphate/Poly(lactic-co-glycolide) Bone Substitute Used in Edentulous Ridge Preservation for Late Implant Placement: Case Series.

Introduction: The bioresorbable polymer poly(lactide-co-glycolic acid) (PLGA) coated β-tricalcium phosphate (β-TCP) (β-TCP/PLGA) bone substitute hardens into a stable and porous hard tissue scaffold when exposed to body fluids. Effectiveness of the novel alloplast has been examined in edentulous ridge preservation (ERP) following tooth extraction with subsequent early endosseous dental implant placement; however, it is not clear that the biomaterial is capable of maintaining the edentulous ridge volume to allow for late implant placement due to the rapid bioresorption property of β-TCP. The purpose of this case series is to determine if the β-TCP/PLGA bone substitute is a desirable material for ERP followed by late implant placement.

Inhibitory effects of tumor necrosis factor-alpha on migration of human periodontal ligament cells.

Background: Tumor necrosis factor-alpha (TNF-alpha) is associated with chronic gingival inflammation and is suspected to influence periodontal destruction. However, the exact roles of TNF-alpha in wound healing and periodontal tissue regeneration are largely unknown. In the present study, we examined the effects of TNF-alpha on migration and proliferation of human periodontal ligament (PDL) cells.

[Application of dietary supplement to periodontal disease and osteoporosis].

It is known that there is a relationship between various systemic diseases, life style and periodontal disease. In such a situation, it is becoming clear a relationship between the systemic bone density and the mandibular bone, alveolar bone density and clinical periodontal parameters. And it is also cleared that to lower common risk factors related to these conditions might be useful to prevent osteoporosis and periodontal disease.