Publications by authors named "Akane Shimakura"
Article Synopsis
- After pancreaticoduodenectomy, 20-40% of patients experience steatotic liver disease (SLD), but the role of specific gene polymorphisms (PNPLA3 and TM6SF2) in this condition post-surgery is not well understood.
- A study involving 43 pancreatic cancer patients assessed these gene variants and their correlation with SLD and high hepatic fibrosis indexes (HFI) after surgery.
- Results indicated that while PNPLA3 variants showed no significant association, the TM6SF2 minor allele was linked to a higher incidence of steatohepatitis, suggesting its potential impact on liver health after the procedure.*
Article Synopsis
- The study aimed to assess whether total bile acid (TBA) levels can help identify patients with decompensated cirrhosis who need echocardiography for diagnosing portopulmonary hypertension.
- Out of 135 patients evaluated, elevated TBA levels and main pulmonary artery diameter were linked to higher tricuspid regurgitation pressure gradient (TRPG), suggesting TBA can indicate TRPG elevation effectively.
- However, for patients taking ursodeoxycholic acid (UDCA), the effectiveness of TBA in diagnosing TRPG elevation was reduced, indicating the need for careful interpretation in such cases.
Recent Advances in Endoscopic Ultrasound for Gallbladder Disease Diagnosis.
Diagnostics (Basel)
February 2024
Article Synopsis
- Gallbladder disease is categorized mainly into GB wall-thickening and protuberant lesions, which includes conditions like cholecystitis and GB carcinoma.
- Recent advancements in diagnosis focus on techniques such as endoscopic ultrasound (EUS) and contrast-enhanced harmonic EUS (CH-EUS) that effectively assess GB lesions.
- The review also discusses the role of EUS-guided fine-needle aspiration (EUS-FNA) and highlights the growing impact of artificial intelligence in diagnosing gallbladder diseases.
Article Synopsis
- This study compares two needle types used in endoscopic ultrasound-assisted tissue acquisition (EUS-TA) for collecting cancer tissue samples: the EZ Shot 3 Plus (EZ3) and the SonoTip TopGain (TopGain).
- Researchers analyzed data from EUS-TA cases between 2010 and 2021, finding that the TopGain needle collected tissue with a surface area of 4 mm or more in a higher percentage of cases (68.6%) compared to the EZ3 needle (42.9%).
- The findings suggest that using the TopGain needle is more effective for obtaining larger tissue samples necessary for accurate cancer gene panel testing, indicating its potential benefits in clinical practice.
Background: This study aimed to evaluate the usefulness of discharge standards in outpatients undergoing sedative endoscopy by comparing the modified post-anesthetic discharge scoring system (MPADSS) and the modified Aldrete score.
Methods: We prospectively enrolled 376 outpatients who underwent gastrointestinal endoscopy under midazolam sedation; 181 outpatients were assessed regarding discharge after sedative endoscopy using the MPADSS (group M), and 195 patients were assessed by the modified Aldrete score (group A). The clinical characteristics, types of endoscopy, endoscopic outcomes, and anesthesia outcomes were evaluated between the two groups.
Background And Aim: This study aimed to compare patients with and without sedation during emergency endoscopy for upper gastrointestinal bleeding (UGIB) and to clarify the safety and efficacy of sedation in emergency endoscopy.
Methods: We retrospectively collected 389 patients who underwent emergency endoscopy for UGIB at Ureshino Medical Center from 2016 to 2021. Patients were divided into two groups: sedation group during emergency endoscopy and nonsedation group.
An 86-year-old woman presented with a history of endoscopic papillary sphincterotomy for bile duct stones and diverticulitis. The patient was admitted as an emergency case of acute cholangitis due to choledocholithiasis, underwent endoscopic bile duct stenting, and was discharged with a plan for endoscopic lithotripsy. One month later, the patient was readmitted owing to abdominal pain.
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