Solitary ulcer of the rectum: report of a case and review of the literature.

A 13-year-old girl with Prader-Willi syndrome was admitted to our hospital with an 18-month history of anal bleeding and mucus discharge on defecation. Physical examination revealed obesity, hypogonadism, hypotonia and hypomentia. On digital examination, a nodular mass was palpated on the right wall of the ampulla recti, which was suspected to be carcinoma on a barium enema study.

alpha-Guanidinoglutaric acid in cobalt-induced epileptogenic cerebral cortex of cats.

Guanidino compounds in the cobalt-induced epileptogenic cerebral cortex of cats were fluorometrically analysed by a JASCO G-520 guanidino compounds analyser, and an unknown high peak was observed in the chromatogram that was identical to the peak of authentic alpha-guanidinoglutaric acid. In another experiment, the substance was extracted from the cobalt focus tissue, converted into dimethylpyrimidyl derivative-butylester, and analysed by a GC/MS technique. The mass spectrum of the substance was identical to the dimethylpyrimidyl derivative of alpha-guanidinoglutaric acid butylester (M+ = 365).

The role of gastric glucagon immunoreactivity in pancreatectomized dogs.

Immunoreactive glucagon (IRG) or glucagon immunoreactivity is known to be increased in the plasma of insulin-deprived pancreatectomized dogs, most of it originating in the stomach. We attempted to clarify the extent to which gastric IRG is involved in glycogenolysis in the liver of insulin-deprived, pancreatectomized dogs. Mongrel dogs underwent total pancreatectomy.

Properties of hydrogen peroxide-induced histamine release from rat mast cells.

Incubation of rat peritoneal mast cells with hydrogen peroxide results in a marked release of histamine. Maximal release is observed with 0.05-0.

Validity of long-term recordings of electrical activity of the stomach by chronically implanted monopolar suction electrodes in the conscious dog.

Twenty-four-hour changes in gastric electrical activity were recorded in conscious dogs by means of chronically implanted monopolar suction electrodes. The electrical activity consisted of an initial potential followed by a second potential with various amplitude and duration depending upon the time after feeding. Amplitude of the second potential was well correlated to magnitude of each contraction.

The physicochemical nature and biological function of extrapancreatic immunoreactive glucagon.

The physicochemical nature and biological function of extrapancreatic immunoreactive glucagon in the plasma of totally pancreatectomized dogs were studied. The experimental animals were divided into two groups. Group A received only total pancreatectomy while group B had total pancreatectomy plus total gastrectomy.

Histochemical observations of polyglucose synthesized by enzyme activities in human gastric carcinoma.

Polyglucose particles histochemically synthesized from glucose 1-phosphate by phosphorylase and branching glycosyltransferase were observed in the gastric carcinoma cells, in intestinal metaplastic epithelium of the gastric mucosa and in fetal epithelium of the fetal gastric mucosa by light and electron microscopical studies. Light microscopical observations resembled those in previous reports. As for the electron microscopical observations, in gastric carcinoma cells, the polyglucaose synthesizing area were expansively widened by a deposition of synthesized polyglucose particles.

Anti-inflammatory activity of a proteolytic enzyme, Prozime-10.

Prozime-10 (P-10), a proteolytic enzyme extracted from cultured broth of Aspergillus melleus, was injected intravenously into rats in dosages of 1--10 mg/kg and was found to alleviate carrageenin edema. Thermal denaturation diminished not only the proteolytic activity but also the antiedematous effect. Carrageenin-induced granuloma pouches in rats were reduced by P-10 in a dose-dependent manner (1--5 mg/kg).

Inhibition of human leukocyte migration in agar by 3-M potassium chloride extracts of stomach, colon, and lung cancers.

Inhibition of leukocyte migration in agarose-agar was used as a probe for tumor-associated antigen in 3-M KCl solubilized extracts of gastric, colon, and lung cancers from humans. Twelve of 40 (30%) leukocyte preparations from gastric cancer patients, 10 of 21 (48%) from colon cancer patients, and 7 of 14 (50%) from lung cancer patients were inhibited by their respective histologically homologus cancer extract. However, among 75 preparations from various cancer patients, leukocytes from only 2 gastric cancer patients were inhibited by paired normal gastric tissue extracts.

Postoperative evaluation of the exocrine function of the pancreas after pancreaticoduodenectomy.

The exocrine function of the residual pancreas of eight patients who underwent pancreaticoduodenectomy was studied with the 131I-triolein absorption test and by 75Se-selenomethionine scintiscanning. In six patients, a pancreaticojejunostomy was performed, while in the other two patients, the pancreatic duct of the residual pancreas was ligated. The fecal 131I-triolein excretory rate in the duct ligation group was more than 50 per cent, while, in all but one patient in the duct anastomosis group, it was less than 10 per cent.

Anti-allergic properties of a new histamine antagonist, 4-(p-chlorobenzyl)-2- [N-methyl-perhydroazepinyl-(4)]-1-(2H)-phthalazinone hydrochloride (azelastine).

Anti-allergic properties of 4-(p-chlorobenzyl)-2 [N-methyl-perhydroazepinyl-(4)]-1-(2H)-phthalazinone hydrochloride (azelastine, A-5610) were investigated focusing the most attention on its decongestive effect. Intravenous injection of azelastine into anesthetized dogs with doses more than 0.1 mg/kg prevented the changes in nasal impedance provoked by histamine sprayed into the nasal cavity.

Evaluation of fibergastroscopic biopsy in the diagnosis of gastric cancer: a study of 339 cases.

Three hundred and sixty-five biopsies under direct vision, using a fibergastroscope, were performed on 339 patients with gastric cancer from 1966 to 1975. Diagnostic accuracy improved with an increased in the number of biopsy specimens and reached 100% when 6 or more biopsy specimens were obtained. Positive specimens were obtained with 48.

Cutaneous mycosis caused by Paecilomyces lilacinus.

A 20-year-old woman had erythematous scaly plaques persistent for 15 years on the left cheek. Cultures from scales and biopsy specimens on Sabouraud's glucose agar repeatedly yielded floccose lilac colonies, and those on a Czapek's solution agar plate developed deep purplish red pigment, which is characteristic of Paecilomyces lilacinus. The PAS stain of the tissue section showed ovoid, divergent, or club-shaped fungal elements among the inflammatory cells or in giant cells.

Effects of diphenhydramine, naphazoline and m-amino-alpha(1-aminoethyl)benzyl alcohol dihydrochloride on the nasal mucosa determined by impedance method: a simple method for evaluation of nasal decongestant.

A simple, new method was devised for evaluating nasal decongestants. In anesthetized dogs, two needle electrodes were inserted bilaterally into the superficial mucosa of the nasal wings. An impedance plethysmorgraphy provided with a DC output was used to measure impedance between the two electrodes.