Publications by authors named "Ajla Smajlovic"
Halogenated boroxine K[BOFOH] (HB), an inorganic derivative of cyclic anhydride of boronic acid, is patented as a boron-containing compound with potential for the treatment of both benign and malignant skin changes. HB has effectively inhibited the growth of several carcinoma cell lines. Because of the growing interest in autophagy induction as a therapeutic approach in bladder carcinoma (BC), we aimed to assess the effects of HB on metabolic phenotype and autophagy levels in 5637 human bladder carcinoma cells (BC).
View Article and Find Full Text PDFAnti-proliferative effects of halogenated boroxine - K(BOFOH) (HB) - have been confirmed in multiple cancer cell lines, including melanoma, but the exact mechanism of action is still unknown. This study aimed to determine its cytotoxic effects on human Caucasian melanoma (GR-M) cell growth as well as on the expression of cell death-related genes , and . GR-M and peripheral blood mononuclear (PBM) cells were treated with different HB concentrations and their growth inhibition and relative gene expression profiles were determined using the Alamar blue assay and real-time PCR.
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- Imiquimod (IMQ) effectively induces psoriasis-like symptoms in mice and serves as a valuable model for testing new treatments, but its effects on different rat strains remain under-researched.
- The study evaluated the impact of IMQ and betamethasone on psoriasis, measuring changes in lesion severity, histology, and cytokine levels, with significant skin lesion reversal observed after betamethasone treatment (p=0.03).
- Results indicated notable gene expression changes, with 14 genes up-regulated by IMQ and 4 down-regulated after betamethasone treatment, highlighting the model's potential for advancing psoriasis research and drug testing.