Publications by authors named "Ajithkumar K"

Pemphigus is an autoimmune blistering disorder characterized by the presence of intraepidermal blisters and erosions, primarily affecting the mucosa and/or skin. There are no established Indian guidelines for the management of pemphigus, and Western guidelines cannot be directly applied due to differences in clinicodemographic profiles, comorbidities, and resource limitations. These guidelines aim to provide Indian dermatologists with evidence-based and consensus-driven recommendations for the management of pemphigus vulgaris (PV) and pemphigus foliaceous (PF), taking into account the unique challenges posed by the Indian healthcare setting.

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Novel species of fungi described in this study include those from various countries as follows: , from accumulated snow sediment sample. , on leaf spots of . , on submerged decaying wood in sea water, on , as endophyte from healthy leaves of .

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Purpose: The purpose of the present study was to translate and culturally validate the University of Washington Quality of Life Questionnaire, Version 4.1 (UW-QOL v4.1) in Malayalam, a language commonly used in the state of Kerala in India.

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Background: Chronic spontaneous urticaria (CSU) is a dermatosis with a significant psychological component. Only a few studies have assessed the quality of life (QoL) and perceived stress in CSU patients.

Objectives: To evaluate the QoL and perceived stress in patients with CSU.

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Article Synopsis
  • Chia is a commercially important crop in India, particularly in Karnataka, where a field survey revealed signs of virescence with symptoms affecting 2-4% of the crop in a 30-hectare area.
  • The symptoms included malformed shoots, thickened stems, and reduced floral parts characterized by greenish florets.
  • DNA analysis confirmed the presence of phytoplasma associated with the symptoms, specifically identifying it as Candidatus Phytoplasma aurantifolia with high sequence similarity to other known phytoplasmas.
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Background: Recent studies indicate an upsurge of primary cutaneous lymphoma (PCL) in the Indian population. Of late, we too have come across varied presentations of PCL in relatively younger individuals. Hence, we decided to study the clinical and immunohistological profile of patients with PCL in our department.

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Article Synopsis
  • The study introduces new species of fungi discovered in various environments, including leaves, soil, and dead organic matter across different countries.
  • These fungi were identified based on their morphological features and DNA barcodes, confirming their uniqueness.
  • The findings are documented in the publication "Fungal Planet description sheets," highlighting the diversity and ecological roles of the newly described fungi.
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Antifungal efficacy of against trichothecene-producing spp. was investigated in maize, sorghum, and wheat. The three cereals were subjected to four treatments as control (T1), alone (T2), combination of and treatment (T3), and only (T4).

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Context: Drug reaction with eosinphilia and systemic symptoms (DRESS) and drug-induced hypersensitivity syndrome (DiHS) represent the same spectrum of a drug reaction.

Aims: To compare the clinical profile of patients diagnosed as definite/probable DRESS by the Registry of Severe Cutaneous Adverse Reaction (RegiSCAR) scoring system and as atypical DiHS by Japanese consensus group criteria.

Settings And Design: We did a retrospective study in a tertiary referral center.

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Context: Autoimmune diseases, organ dysfunction and new drug allergies are mentioned as long-term complications after DRESS. There is scarcity of data on this from the country.

Aims: To determine the frequency of autoimmune diseases, organ dysfunction, and new drug allergies after the resolution of DRESS.

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Linseed commonly called as flaxseed (Linum usitatissimum Linn.) is an important oilseed crop cultivated widely in Northern parts of Karnataka. During, 2019 (January-February), a characteristic disease was noticed with symptoms that resembled phytoplasma or like disease symptoms.

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Prostaglandins are a group of important cell-signaling molecules involved in the regulation of ovarian maturation, oocyte development, egg laying and associated behaviors in invertebrates. However, the presence of prostaglandin E (PGE), the key enzymes for PGE biosynthesis and its interference by drugs were not investigated previously in the ovary of ticks. The present study was undertaken to assess the modulation of the PGE-mediated pathway in the eclosion blocking effect of flumethrin and terpenoid subfraction isolated from in ticks.

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Background: The purpose of this paper is to map the number of concerns on the dimensions in Head and Neck Patient Concerns Inventory (PCI) on to the health utility (HU) index scores on Euroqol-Five Dimensions-Five levels {EQ-5D-5L) .

Methods: This is a cross-sectional survey conducted in patients who have completed their treatment. Four candidate models were considered, three based on ordinary least squares regression (OLS) and one two-parts model.

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Background: Worldwide, a declining trend is observed in sexually transmitted infections of bacterial origin which is reflected as a rise in the proportion of viral sexually transmitted infections.

Aims: To find out the clinical referral patterns of sexually transmitted infections among patients who attended the sexually transmitted infection clinic attached to Dermatology and Venereology Department of Government Medical College, Kozhikode from 1.1.

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Background: Detection of peripheral nerve thickening and nerve function impairment is crucial in the diagnosis and the management of leprosy.

Aims And Objectives: (1) To document the cross-sectional area, echotexture and blood flow of peripheral nerves in healthy controls and leprosy cases using high-resolution ultrasound, (2) to compare the sensitivities of clinical examination and high-resolution ultrasound in detecting peripheral nerve thickening in leprosy.

Methods: Peripheral nerves of 30 leprosy patients and 30 age- and sex-matched controls were evaluated clinically and by high-resolution ultrasound.

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Context: Repeated trauma involving extremities (in the setting of peripheral neuropathy) and poor vascularity that impairs wound healing are important causes of disability and deformity in leprosy patients. Nail changes can serve as indicators of trophic changes due to leprosy.

Aims: To describe the onychoscopy findings in leprosy cases and to identify any specific findings in leprosy patients in comparison to controls.

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Context: Lepra reactions if not managed promptly are an important cause of sudden onset nerve palsy and disability due to leprosy.

Aim: To evaluate the usefulness of histology in predicting type 1 lepra reaction.

Setting And Design: After obtaining clearance from institutional research and ethics committees, all histologically proven borderline tuberculoid patients diagnosed at our center from 1.

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Article Synopsis
  • - Humans have historically utilized various plant parts for preventing and treating illnesses, with many plants containing beneficial secondary metabolites known for their biological activities, such as antitumor and anti-inflammatory effects.
  • - The study focuses on Pamp. (Compositae), a plant used in southern India for controlling pests, particularly assessing the acaricidal activity of its ethanolic leaf extract against ticks, which are known to spread serious diseases and negatively impact livestock production.
  • - Chemical tick control methods face challenges like high costs and environmental risks, making plant-based formulations a promising alternative, with prior research supporting the efficacy of various medicinal plants in combatting ectoparasites.
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Background: There are conflicting reports on the association between interface dermatitis and hepatic involvement in DRESS.

Methods: A cross-sectional analysis of the clinical and the histopathologic features of DRESS was performed to study the association between the histopathology of the skin rash and hepatic involvement.

Results: The clinical and the histopathologic findings were evaluated in 40 cases of DRESS.

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