FertilitY Predictor-a machine learning-based web tool for the prediction of assisted reproduction outcomes in men with Y chromosome microdeletions.

Purpose: Y chromosome microdeletions (YCMD) are a common cause of azoospermia and oligozoospermia in men. Herein, we developed a machine learning-based web tool to predict sperm retrieval rates and success rates of assisted reproduction (ART) in men with YCMD.

Methods: Data on ART outcomes of men with YCMD who underwent ART were extracted from published studies by performing a systematic review.

Synergistic Integration of Carbon Quantum Dots in Biopolymer Matrices: An Overview of Current Advancements in Antioxidant and Antimicrobial Active Packaging.

Approximately one-third of the world's food production, i.e., 1.

Structural modification of nickel tetra(thiocyano)corroles during electrochemical water oxidation.

In this study, we present two fully characterized nickel tetrathiocyanocorroles, representing a novel class of 3d-metallocorroles. These nickel(II) ions form square planar complexes, exhibiting a d-electronic configuration. These anionic complexes are stabilized by the electron-withdrawing SCN groups on the bipyrrole unit of the corrole.

Structural and biophysical analysis of cytochrome P450 2C9*14 and *27 variants in complex with losartan.

The human cytochrome P450 (CYP) 1, 2 and 3 families of enzymes are responsible for the biotransformation of a majority of the currently available pharmaceutical drugs. The highly polymorphic CYP2C9 predominantly metabolizes many drugs including anticoagulant S-warfarin, anti-hypertensive losartan, anti-diabetic tolbutamide, analgesic ibuprofen, etc. There are >80 single nucleotide changes identified in CYP2C9, many of which significantly alter the clearance of important drugs.

The isomer-sensitive electrochemical HER of ruthenium(II)-hydrido complexes involving redox-active azoheteroaromatics.

The article deals with the development of isomeric ruthenium(II)-hydrido complexes [Ru(H)(L1)(PPh)(CO)]ClO ([1a]ClO-[1b]ClO)/[Ru(H)(L2)(PPh)(CO)]ClO ([2a]ClO-[2b]ClO) involving azo coupled L1 [L1: ()-1,2-bis(1-methyl-1-pyrazol-3-yl)diazene]/L2 [L2: ()-1,2-bis(4-iodo-1-methyl-1-pyrazol-3-yl)diazene], respectively. Structural evaluation of the complexes affirmed the conformation of the coordinated/uncoordinated pyrazole groups of L and its unperturbed neutral azo (NN) state. Isomeric forms in [1a]ClO/[1b]ClO or [2a]ClO/[2b]ClO differed with respect to the and orientations of the coordinated CO and N(azo) donor of L, respectively.

Interactions of Turmeric- and Curcumin-Functionalized Gold Nanoparticles with Human Serum Albumin: Exploration of Protein Corona Formation, Binding, Thermodynamics, and Antifibrillation Studies.

In order to better understand the bioavailability and biocompatibility of polyphenol-assisted surface-modified bioengineered nanoparticles in nanomedicine applications, here, we address a series of photophysical experiments to quantify the binding affinity of serum albumin toward polyphenol-capped gold nanoparticles. For this, two different gold nanoparticles (AuNPs) were synthesized via the green synthesis approach, where curcumin and turmeric extract act as reducing as well as capping agents. The size, surface charge, and surface plasmon bands of the AuNPs were highly affected by the adsorption of human serum albumin (HSA) during protein corona formation, which was investigated using dynamic light scattering (DLS), ξ-potential, ultraviolet-visible (UV-vis) spectroscopy, and transmission electron microscopy (TEM) measurements.

Low-Loss Paper-Substrate Triple-Band-Frequency Reconfigurable Microstrip Antenna for Sub-7 GHz Applications.

In this paper, a low-cost resin-coated commercial-photo-paper substrate is used to design a printed reconfigurable multiband antenna. The two PIN diodes are used mainly to redistribute the surface current that provides reconfigurable properties to the proposed antenna. The antenna size of 40 mm × 40 mm × 0.

C-H Bond Activation by an Antimony(V) Oxo Intermediate Accessed through Electrochemical Oxidation of Antimony(III) Tetrakis(thiocyano)corrole.

A new class of antimony(III) corroles has been described. The photophysical properties of these newly synthesized tetrakis(thiocyano)corrolatoantimony(III) derivatives having four SCN groups on the bipyrrole unit of corrole are drastically altered compared to their β-unsubstituted corrolatoantimony(III) analogues. The UV-vis and emission spectra of tetrakis(thiocyano)corrolatoantimony(III) derivatives are significantly red-shifted (roughly 30-40 nm) in comparison with their β-unsubstituted corrolatoantimony(III) derivatives.

Quad Element MIMO Antenna for C, X, Ku, and Ka-Band Applications.

This article presents a quad-element MIMO antenna designed for multiband operation. The prototype of the design is fabricated and utilizes a vector network analyzer (VNA-AV3672D) to measure the S-parameters. The proposed antenna is capable of operating across three broad frequency bands: 3-15.

State-of-the-Art Insights and Potential Applications of Cellulose-Based Hydrogels in Food Packaging: Advances towards Sustainable Trends.

Leveraging sustainable packaging resources in the circular economy framework has gained significant attention in recent years as a means of minimizing waste and mitigating the negative environmental impact of packaging materials. In line with this progression, bio-based hydrogels are being explored for their potential application in a variety of fields including food packaging. Hydrogels are three-dimensional, hydrophilic networks composed of a variety of polymeric materials linked by chemical (covalent bonds) or physical (non-covalent interactions) cross-linking.

Exploring Ligand-Controlled C Product Selectivity in Carbon Dioxide Reduction with Copper Metal-Organic Framework Nanosheets.

The suitable choice of an electrocatalyst is crucial in controlling the selectivity of electrocatalytic CO reduction products. Herein, we have explored the effect of different ligand environments in 2D metal-organic frameworks (MOFs), viz., copper naphthalenedicarboxylate (Cu-UNDC) and copper benzenedicarboxylate (Cu-UBDC).

Nitrogen substitution induced lattice contraction in nickel nanoparticles for electrochemical hydrogen evolution from simulated seawater.

Herein, we demonstrate a facile method for the introduction of nitrogen in the lattices of nickel nanoparticles to form NiN ( = 0.13, 0.20, 0.

Phenolic Compounds in Active Packaging and Edible Films/Coatings: Natural Bioactive Molecules and Novel Packaging Ingredients.

In recent years, changing lifestyles and food consumption patterns have driven demands for high-quality, ready-to-eat food products that are fresh, clean, minimally processed, and have extended shelf lives. This demand sparked research into the creation of novel tools and ingredients for modern packaging systems. The use of phenolic-compound-based active-packaging and edible films/coatings with antimicrobial and antioxidant activities is an innovative approach that has gained widespread attention worldwide.

The plant nucleoplasmin AtFKBP43 needs its extended arms for histone interaction.

The nucleoplasmin family of histone chaperones is a key player in governing the dynamic architecture of chromatin, thereby regulating various DNA-templated processes. The crystal structure of the N-terminal domain of Arabidopsis thaliana FKBP43 (AtFKBP43), an FK506-binding immunophilin protein, revealed a characteristic nucleoplasmin fold, thus confirming it to be a member of the FKBP nucleoplasmin class. Small-Angle X-ray Scattering (SAXS) analyses confirmed its pentameric nature in solution, and additional studies confirmed the nucleoplasmin fold to be highly stable.

Biophysical interaction between lanthanum chloride and (CG) or (GC) repeats: A reversible B-to-Z DNA transition.

The transition from right-handed to left-handed DNA is not only acts as the controlling factor for switching gene expression but also has equal importance in designing nanomechanical devices. The (CG) and (GC) repeat sequences are well known model molecules to study B-Z transition in the presence of higher concentration of monovalent cations. In this communication, we report a cyclic transition in (CG) DNA using millimolar concentration of trivalent lanthanide salt LaCl.

Promoting sustainable packaging applications in the circular economy by exploring and advancing molded pulp materials for food products: a review.

Packaging ensures the safe handling and distribution of fresh and processed food products via diverse supply chains, and has become an indispensable component of the food industry. However, the rapidly expanding use of plastics, especially single-use plastics, as packaging material leads to inadequate waste management, littering, and consequently serious environmental damage, which predominantly affects marine and freshwater sources. Thus, the use of plastics for packaging purposes has become a major public concern and hence a concern among global policymakers.

Crystal packing reveals rapamycin-mediated homodimerization of an FK506-binding domain.

Chemically induced dimerization (CID) is used to induce proximity and result in artificial complex formation between a pair of proteins involved in biological processes in cells to investigate and regulate these processes. The induced heterodimerization of FKBP fusion proteins by rapamycin and FK506 has been extensively exploited as a chemically induced dimerization system to regulate and understand highly dynamic cellular processes. Here, we report the crystal structure of the AtFKBP53 FKBD in complex with rapamycin.

In Vitro Characterization of Histone Chaperones using Analytical, Pull-Down and Chaperoning Assays.

Histone proteins associate with DNA to form the eukaryotic chromatin. The basic unit of chromatin is a nucleosome, made up of a histone octamer consisting of two copies of the core histones H2A, H2B, H3, and H4, wrapped around by the DNA. The octamer is composed of two copies of an H2A/H2B dimer and a single copy of an H3/H4 tetramer.

Decellularization of Skin Tissue.

Biomaterials science encompasses elements of medicine, biology, chemistry, materials, and tissue engineering. They are engineered to interact with biological systems to treat, augment, repair, or replace lost tissue function. The choice of biomaterial depends on the procedure being performed, the severity of the patient's condition, and the surgeon's preference.

Coping Strategies and Perception toward Drugs, Electronic Gadgets, and Media in Relation to Stress: A Cross-sectional Study among Residents of a Suburban Area.

Background And Objectives: Stress is an indispensable part of modern-day living. The study deals with coping strategies by the participants and their perception toward drugs, electronic gadgets, and media as stress creators, busters, or relievers.

Materials And Methods: A cross-sectional study was conducted among 400 community dwellers in a suburban area of Delhi.

Palliative oral care in patients undergoing radiotherapy: Integrated review.

Maintaining a patient's quality of life is main the aim while treating cancer patients. Patients getting treated for oral cancer encountered with numerous symptoms at the time of radiotherapy and most of these are side effect which can persist even after few months to year after the treatment gets over. Radiotherapy is a vital aspect of both curative and palliative cancer care.

The Adverse Effect of COVID Pandemic on the Care of Patients With Kidney Diseases in India.

Introduction: The coronavirus disease 2019 (COVID-19) pandemic has affected the care of patients with noncommunicable diseases, including those suffering from kidney-related ailments. Many parts of the world, including India, adopted lockdown to curb community transmission of disease. The lockdown affected transportation, access to health care facilities, and availability of medicines and consumables as well as outpatient and inpatient services.