Development of polyvinyl alcohol-gelatin membranes for antibiotic delivery in the eye.

Aim: The aim of the present study was to develop biosynthetic hybrid polymer-based ocular insert for topical administration of antibiotics for treatment of ocular infections.

Methods: Ciprofloxacin hydrochloride-loaded three different inserts were prepared by solution casting method by esterification of a biopolymer (gelatin) with a synthetic polymer (polyvinyl alcohol, PVA). Esterification between PVA and gelatin was confirmed by Fourier transform infrared spectroscopy.

Investigation of in vitro iontophoresis facilitated transdermal delivery of glycine.

The research presented in this paper discusses the potential of iontophoresis facilitated transdermal delivery of glycine. Iontophoresis has been widely investigated as a noninvasive transdermal drug delivery system. Iontophoresis is the use of a low electric current to carry ionized as well as unionized drug molecules across tissues (like skin) in a noninvasive technique.

Polyvinyl alcohol-glycine composite membranes: preparation, characterization, drug release and cytocompatibility studies.

The purpose of this study was to prepare a polyvinyl alcohol-glycine composite membrane to deliver glycine directly to a site of injury to be utilized for the synthesis of collagen for complete healing of a wound. Polyvinyl alcohol (PVA) and glycine (Gly) blended composite membranes, with different PVA:glycine ratios (1:0.2, 1:0.

Synthesis and characterization of pectin/PVP hydrogel membranes for drug delivery system.

The purpose of the present study was to develop and design pectin and polyvinyl pyrrolidone (PVP) blended hydrogel membranes (PEVP), with different pectin: PVP ratios (1:0.2, 1:0.4, 1:0.

Development of pH sensitive polyacrylamide grafted pectin hydrogel for controlled drug delivery system.

In the present study an attempt was made to graft polyacrylamide on pectin. The grafted polymer was characterized by FTIR spectroscopy, differential scanning calorimetry and X-ray diffraction. Rheological property of pectin solution was compared with the product solution.

Preparation and characterization of polyvinyl alcohol-gelatin hydrogel membranes for biomedical applications.

The purpose of this research was to design and develop hydrogels by esterification of polyvinyl alcohol (PVA) with gelatin. The membranes were characterized by Fourier Transform Infrared (FTIR) spectroscopy, x-ray diffraction (XRD), and differential scanning calorimetry. The viscosity of the esterified product (as solution) was compared with the mixture of PVA and gelatin of the same composition.

Biocompatibility and antibacterial activity studies of polyamidoamine (PAMAM) dendron, side chain dendritic oligourethane (SCDOU).

Cytotoxicity of both polyamidoamine dendritic diol (PAMAM) and side chain dendritic oligourethane (SCDOU) was studied through interaction with mammalian fibroblast cells (L929). Cell metabolic activity in the presence of dendritic polymers was measured using an MTT assay exhibiting significant cell viability. Additionally, the antibacterial activity of PAMAM dendron, SCDOU, as well as their silver-doped structures was studied against Escherichia coli bacteria.

New insight into the synthesis of a novel azo-based optically active polyamidoamine side chain dendritic polyester architectural photoswitch.

[reaction: see text] A novel chiral polyamidoamine side chain dendritic polyester 4 has been synthesized and found to be a photoresponsive system undergoing reversible E/Z photochemical/thermal isomerization of azo units. Thorough characterization (IR,UV-vis, NMR, FAB-MS, elemental analysis, optical rotation, etc.) were performed to ascertain the structures of dendrimers 2, 3, and 4.