Pulsed plasma surface functionalized nanosilver for gene delivery.

Lack of suitable surface properties in biomaterials is an acute challenge for their utilization in nucleic acid delivery, since surface plays a vital role in cell adhesion/uptake and immunity. Low pressure cold plasma is a promising technology for functionalization and surface modification of materials, in an effective, environment friendly and economical way. In this investigation we have modified the surface of silver nanoparticles (AgNPs) with chitosan biopolymer, using plasma treatment, to extend their application scope in intracellular DNA delivery.