Efficient antimicrobial applications of two novel supramolecular metallogels derived from a l(+)-tartaric acid low molecular weight gelator.

Novel metallogels were synthesized using l(+)-tartaric acid as a gelator, along with cadmium(ii)-acetate and mercury(ii)-acetate in ,-dimethyl formamide at room temperature. Rheological analyses confirmed the mechanical stability of Cd(ii)- and Hg(ii)-metallogels under varying conditions. Characterization through EDX mapping and FESEM imaging provided insights into their chemical constituents and microstructural features.

Biomedical applications of biodegradable polycaprolactone-functionalized magnetic iron oxides nanoparticles and their polymer nanocomposites.

Magnetic nanoparticles (MNPs) have gained significant attention among several nanoscale materials during the last decade due to their unique properties. These properties make them successful nanofillers for drug delivery and a number of new biomedical applications. MNPs are more useful when combined with biodegradable polymers.

Analytical approaches for screening of per- and poly fluoroalkyl substances in food items: A review of recent advances and improvements.

Per and polyfluoroalkyl substances (PFAS) are a group of man-made chemicals characterized by their ubiquitous nature in all environmental compartments which makes them of increasing concern due to their persistence, bioaccumulation, and toxicity (PBT). Several instrumental methodologies and separation techniques have been identified in the literature for the detection and quantification of PFAS in environmental samples. In this review, we have identified and compared common separation techniques adopted for the extraction of PFAS in food items, and analytical methodologies for identification and quantification of PFAS in food items of plant and animal origin, highlighting recent advances in tandem techniques for the high selectivity and separation of PFAS related compounds as well as knowledge gaps and research needs on current analytical methodologies.

Impacts of Binary Oxide Nanoparticles on the Soybean Plant and Its Rhizosphere, Associated Phytohormones, and Enzymes.

The utilization of binary oxide nanoparticles is geometrically increasing due to their numerous applications. Their intentional or accidental release after usage has led to their omnipresence in the environment. The usage of sludge or fertilizer containing binary oxide nanoparticles is likely to increase the chance of the plants being exposed to these binary oxide nanoparticles.

Network Pharmacology- and Molecular Dynamics Simulation-Based Bioprospection of for Type-2 Diabetes Care.

The medicinal herb (rooibos) is globally recognized in type-2 diabetes mellitus (T2DM) treatment due to its known and distinctive compounds. This work utilized network pharmacology (NP) coupled with molecular dynamics simulation in gaining new insight into the anti-diabetic molecular mechanism of action of rooibos teas. It looked at the interactions between rooibos constituents with various relevant protein receptors and signaling routes associated with T2DM progression.

Microbiome of Soybean (Glycine max L.) Rhizosphere from Free State, South Africa.

Soybean develop a symbiotic relationship with the rhizospheric microbial communities. These organisms are important in maintaining soybean growth and health. Soil samples for this study were collected from Free State, South Africa.

Functional Diversity of Microbial Communities in the Soybean ( L.) Rhizosphere from Free State, South Africa.

The plant microbiome is involved in enhancing nutrient acquisition, plant growth, stress tolerance, and reducing chemical inputs. The identification of microbial functional diversity offers the chance to evaluate and engineer them for various agricultural processes. Using a shotgun metagenomics technique, this study examined the functional diversity and metabolic potentials of microbial communities in the rhizosphere of soybean genotype link 678.

The Versatility in the Applications of Dithiocarbamates.

Dithiocarbamate ligands have the ability to form stable complexes with transition metals, and this chelating ability has been utilized in numerous applications. The complexes have also been used to synthesize other useful compounds. Here, the up-to-date applications of dithiocarbamate ligands and complexes are extensively discussed.

Simultaneous removal of organics and heavy metals from industrial wastewater: A review.

The co-existence of heavy metals and organics in industrial effluents is a prevalent problem. These pollutants usually have dissimilar compositions and properties, making their complete removal very tedious even with the use of conventional methods. In some cases, organics and heavy metals usually exist in a mixed matrix in industrial wastes.

Identification and characterization of anti-diabetic principle in Senna alata (Linn.) flower using alloxan-induced diabetic male Wistar rats.

Ethno-pharmacological Relevance: The age-long folkloric use of Senna alata flower (SAF) was recently substantiated with scientific evidence. However, the study did not account for the anti-diabetic principle(s) in SAF.

Aim Of The Study: The study aimed to identify and characterize the bioactive principle(s) responsible for the anti-diabetic activity in SAF.

Deceased donor organ transplantation potential: A peep into an untapped gold mine.

Organ transplantation is the gold standard for treating end-stage organ diseases, many of whom are on waiting lists. The reasons for this include the nonavailability of suitable organs to be transplanted. In many nations, most of these challenges have been surmounted by the adoption of deceased donor program, which is not so in sub-Saharan countries such as Nigeria.

Antidiabetic activity-guided isolation of gallic and protocatechuic acids from Hibiscus sabdariffa calyxes.

We isolated and identified gallic and protocatechuic acids as the antidiabetic principles in Hibiscus sabdariffa using solvent extraction, column chromatographic fractionation, and nuclear magnetic resonance (NMR) spectroscopy. Ethylacetate fraction of the aqueous extract of H. sabdariffa inhibited α-amylase and α-glucosidase with IC of 411.

Nutritional performance and antioxidant activities of roasted and unroasted sprouted sorghum-based weaning diets in Wistar rats.

The nutritional performance and antioxidant profile of sprouted sorghum-based weaning diets were evaluated in weaning wistar rats. Rats were fed basal diet, unroasted germinated sorghum-based diet, roasted germinated sorghum-based diet, or a commercial weaning feed (nutrend) for 28 days. Energy, carbohydrate, crude protein, lipids, crude fiber, and ash contents of the sorghum-based diets compared significantly with FAO/WHO recommendations.

Caffeic acid abrogates 1,3-dichloro-2-propanol-induced hepatotoxicity by upregulating nuclear erythroid-related factor 2 and downregulating nuclear factor-kappa B.

1,3-dichloro-2-propanol is a food-borne contaminant reported to cause liver injury. In this study, we evaluated the protective influence of caffeic acid on 1,3-dichloro-2-propanol-induced hepatotoxicity in rats. Rats were randomized into five groups (A-E).

Protective Influence of on Ciprofloxacin-Induced Neurotoxicity in Male Rats.

(Kuntze) Exell. (Euphorbiacea) leaves are widely used in the treatment of neurological disorders in Nigeria. We investigated the protective effect of aqueous leaf extract of on ciprofloxacin neurotoxicity in male rats.

Lophirones B and C induce oxidative cellular death pathway in Acinetobacter baumannii by inhibiting DNA gyrase.

We evaluated the inactivation of DNA gyrase on the oxidative stress response and sensitivity of A. baumannii to lophirones B and C. The sensitivity of parental and the mutant strains of A.

Contributions of reactive oxygen species, oxidative DNA damage and glutathione depletion to the sensitivity of Acinetobacter baumannii to 2-(2-nitrovinyl) furan.

2-(2-nitrovinyl) furan is a broad-spectrum antibacterial agent with activity against Gram-positive and Gram-negative bacteria. In this study, the contributions of reactive oxygen species, oxidative DNA damage and glutathione depletion to its activity against Acinetobacter baumannii was investigated. Inactivation of sodB, katG and recA lowered the minimum inhibitory concentration of 2-(2-nitrovinyl) furan.

Loperamide-induced cardiotoxicity in rats: Evidence from cardiac and oxidative stress biomarkers.

At therapeutic dose, loperamide is a safe over-the-counter antidiarrheal drug but could induce cardiotoxic effect at a supratherapeutic dose. In this study, we use cardiac and oxidative biomarkers to evaluate loperamide-induced cardiotoxicity in rats. Rats were orally gavaged with 1.

Protocatechuic acid protects against menadione-induced liver damage by up-regulating nuclear erythroid-related factor 2.

Menadione (Vitamin K) is an over-the-counter (OTC) drug used in the treatment of abdominal cramps, colitis, diarrhea, hay fever, hemorrahage, hypoprothrombinemia, and joint pains. In this study, we evaluated the protective influence of protocatechuic acid on menadione-induced hepatotoxicity in rats. Rats were randomized into five groups (A-E) of five rats each.

(+)-Catechin potentiates the oxidative response of Acinetobacter baumannii to quinolone-based antibiotics.

(+)-Catechin is a versatile compound with its pharmacophore (catechol and resorcinol) responsible for prooxidant and antibacterial activities. In this study, we present that demonstrating the synergistic interaction between (+)-catechin and quinolone-based antibiotics, ciprofloxacin and gemifloxacin is related to reactive oxygen species generation. The minimum inhibitory concentration of (+)-catechin against Acinetobacter baumannii AB5075 were considerably lowered for ΔsodB and ΔkatG mutants.

Menadione perturbs oxidative stress biomarkers and testicular function indices of rats.

In this study, we evaluated the influence of menadione on the androgenic, oxidative stress biomarkers, and testicular function indices in rats. Rats (20) were randomized into four groups (A-D) of five rats each. Rats in groups A, B, C, and D received the vehicle of administration (olive oil), 25, 50, or 100 mg/kg body weight menadione intraperitoneally, respectively, for 7 days.

Impact of zinc uptake regulator Zur on the susceptibility and oxidative stress response of Acinetobacter baumannii to antibiotics.

Zinc is a highly coveted redox-inactive micronutrient required for the growth and virulence of Acinetobacter baumannii. In this study, the role of the zinc uptake regulator Zur in the susceptibility and oxidative stress response of A. baumannii to antibiotics was evaluated.

Ferulic acid potentiates the antibacterial activity of quinolone-based antibiotics against Acinetobacter baumannii.

Ferulic acid is a cinnamic derivative of phenolic acid and its pharmacophore (catechol) is responsible for antioxidant, prooxidant and antibacterial activities. In this study, we evaluated the influence of ferulic acid on the antibacterial activity of quinolone-based antibiotics against Acinetobacter baumannii. The minimum inhibitory concentration of ferulic acid against Acinetobacter baumannii AB5075 were considerably lowered for ΔsodB and ΔkatG mutants.

Hydro-Ethanolic Fruit Extract of Reversed Triton-X-100-Induced Hyperlipidaemia in Rats.

This study evaluates the anti-hyperlipidaemic and antioxidant activities of hydro-ethanolic fruits extract of in hyperlipidemia rats. The secondary volatile metabolite constituents of the extract were identified using Gas chromatography. antioxidant activity of the extract (0.

Expanding renal transplantation organ donor pool in Nigeria.

Kidney transplantation is the gold standard for end-stage renal disease. All over the world there are several challenges preventing sufficient organ donation to meet the growing needs of patients on the waiting list. One major challenge which is common to most countries is the shortage of organs from willing living donors.