Publications by authors named "Ajda Medved"
Effect of electrochemotherapy on myogenesis of mouse C2C12 cells in vitro.
Bioelectrochemistry
October 2023
Article Synopsis
- Electrochemotherapy (ECT) is a targeted treatment for skin and certain internal tumors, but its effects on nearby skeletal muscle tissue haven't been thoroughly studied.
- In experiments using the mouse muscle cell line C2C12, higher voltages during ECT maximized cell permeabilization and maintained cell viability for up to four days.
- ECT combined with drugs like bleomycin and cisplatin reduced the viability of muscle cells more significantly in myoblasts than in mature myotubes, with a minor increase in IL-6 indicating early inflammatory responses.