Extension of Law of Limitation in Medical Negligence Cases and Applicability of Discovery Rule: Emerging Indian Perspective.

Practitioners of medicine have a moral as well as legal obligation to serve their patients to the best of their ability, and in recent years the medical profession throughout the world has affirmed this principle. But where there is negligence of this sacred duty, a claim arises. Most civil claims are governed by the law of limitation, which restricts the time in which a plaintiff can bring a suit.

The interplay of plant-based antioxidants, inflammation, and clinical outcomes in asthma: A systematic review.

Background: Asthma is a chronic inflammatory disease and a leading cause of disability, posing a huge economic and social burden. Plant-based antioxidants have the potential to block proinflammatory pathways and protect against oxidative damage, which could improve asthma management.

Objective: This review examines the role of plant-based antioxidants as adjuvant therapy on inflammatory markers and clinical outcomes of adults with asthma.

Assessment of natural radioactivity levels in rice samples and their implications for radiological protection.

This study investigates the levels of natural and artificial radioactivity in rice samples collected from various local markets in Islamabad, Pakistan. The Ra, Th, and K activity concentrations were measured through gamma-ray spectrometry with a NaI(Tl) detector. The average activity concentrations were 1.

Miracle Fruit, a Potential Taste-modifier to Improve Food Preferences: A Review.

Purpose Of Review: The miracle fruit contains the glycoprotein miraculin which can modify the taste perception of food and beverages at low pH conditions, altering the consumers' food preferences. This review aims to critically evaluate all available evidence on miracle fruit/ miraculin and taste modification and its potential role in improving food preferences.

Recent Findings: Miracle fruit suppresses sourness and induces sweetness in acidic food/ beverages.

Comprehensive Analysis of Contaminants in Powdered Milk Samples Using an HPGe for γ Radiation.

: This study aimed to assess the activity concentrations and cancer risk assessments of Th and K in powdered milk samples collected from various suppliers in Pakistan, considering the increasing concern about cancer risks associated with environmental radiological effects related to food consumption. : Specific activity concentrations were determined using a high-resolution, high-purity germanium γ-spectroscopy system. : The specific activity levels of K and Th in the analyzed powdered milk samples were found to be 230.

Centrality and System Size Dependence among Freezeout Parameters and the Implications for EOS and QGP in High-Energy Collisions.

Utilizing the Modified Hagedorn function with embedded flow, we analyze the transverse momenta (pT) and transverse mass (mT) spectra of π+ in Au-Au, Cu-Cu, and d-Au collisions at sNN = 200 GeV across various centrality bins. Our study reveals the centrality and system size dependence of key freezeout parameters, including kinetic freezeout temperature (T0), transverse flow velocity (βT), entropy-related parameter (n), and kinetic freezeout volume (). Specifically, T0 and increase from central to peripheral collisions, while βT and show the opposite trend.

Charged Particles Transverse Momentum and Pseudorapidity Distribution in Hadronic Collisions at LHC Energies.

We present an analysis of the pseudorapidity η and transverse momentum pT distributions of charged hadrons in pp collisions for the kinematic range of 0 View Article and Find Full Text PDF

Analyses of , -, - and - Collisions by Tsallis-Pareto Type Function at RHIC and LHC Energies.

The parameters revealing the collective behavior of hadronic matter extracted from the transverse momentum spectra of π+, π-, K+, K-, , p¯, Ks0, Λ, Λ¯, Ξ or Ξ-, Ξ¯+ and Ω or Ω¯+ or Ω+Ω¯ produced in the most central and most peripheral gold-gold (Au-Au), copper-copper (Cu-Cu) and lead-lead (Pb-Pb) collisions at 62.4 GeV, 200 GeV and 2760 GeV, respectively, are reported. In addition to studying the nucleus-nucleus (AA) collisions, we analyzed the particles mentioned above produced in pp collisions at the same center of mass energies (62.

Pseudorapidity dependence of the bulk properties of hadronic medium in pp collisions at 7 TeV.

The measured charged particle [Formula: see text] spectra in proton-proton collisions obtained by the CMS experiment at CERN is compared with the simulation results of EPOS-LHC and Pythia8.24 models at 7 TeV center-of-mass energy. The Pythia8.

Study of Kinetic Freeze-Out Parameters as a Function of Rapidity in pp Collisions at CERN SPS Energies.

We used the blast wave model with the Boltzmann-Gibbs statistics and analyzed the experimental data measured by the NA61/SHINE Collaboration in inelastic (INEL) proton-proton collisions at different rapidity slices at different center-of-mass energies. The particles used in this study were π+, π-, K+, K-, and p¯. We extracted the kinetic freeze-out temperature, transverse flow velocity, and kinetic freeze-out volume from the transverse momentum spectra of the particles.

Dithiin diisoimides: Synthesis and their antimicrobial studies.

Sixteen derivatives of dithiin diisoimide 2a-2p have been synthesized and screened for antibacterial and antifungal activity. Compounds 2a-2g and 2i-2p are almost same or more active than gentamicine against Acinetobacter. Whereby compound 2,6-didodecyl-H,5H-pyrrolo[3',4',5,6][1,4]dithiino[2,3-c]pyrrole-1,3,5,7(2H,6H)-tetrone (2d) having zone of inhibition 20 mm against Acinetobacter is the most potent among all these compounds and can be used as lead compound for the treatment of Acinetobacter infection.

In Vitro Evaluation of Notch Inhibition to Enhance Efficacy of Radiation Therapy in Melanoma.

Purpose: The scope of radiation therapy is limited in melanoma. Using in vitro melanoma models, we investigated a Notch signaling inhibitor as a radiosensitizer to explore its potential to improve the efficacy of radiation therapy to widen the clinical application of radiation therapy in melanoma.

Methods And Materials: Melanoma cell lines A375, SKMEL28, and G361 were grown using standard tissue culture methods.

Prevalence and antibiotic resistance profiles of Gram negative bacilli associated with urinary tract infections (UTIs) in Karachi, Pakistan.

The aim of this investigation was to determine the prevalence and antibiotic resistance profiles of Gram negative bacilli (GNB) responsible for urinary tract infections (UTIs). Urine specimens were cultured on Cysteine Lactose Electrolyte Deficient Agar (CLED) medium and pathogenic GNB were identified by conventional biochemical methods and automated profile index (API) system and further subjected to antibiotic sensitivity testing by disk diffusion method. Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii were encountered as most frequent GNB in sequence.

Microbial use for azo dye degradation-a strategy for dye bioremediation.

Azo dyes are aromatic compounds with one to many -N=N- groups as well as the leading class of synthetic dyes utilised in commercial solicitations. Azo dyes, released in the environment through textile effluents, have hazardous effects on the aquatic as well as human life. Their persistence and discharge into the environment are becoming a global concern; thus, the remediation of these contaminants has acquired great attention.

Postoperative Craniotomy Pain in Emergent versus Non-emergent Cases.

Background: Postoperative pain control in craniotomies poses multiple challenges. Pain must be addressed, but the use of medications must be weighed against risks. Craniotomies risk neurologic injury and so postoperative examinations are critical.

The Targeting of RNA Polymerase I Transcription Using CX-5461 in Combination with Radiation Enhances Tumour Cell Killing Effects in Human Solid Cancers.

An increased rate of cellular proliferation is a hallmark of cancer and may be accompanied by an increase in ribosome biogenesis and dysregulation in rRNA synthesis. In this regard, CX-5461 has been developed as a novel RNA polymerase I inhibitor and is currently in Phase I/II clinical trials for solid and hematological malignancies. In the present study, interactions between CX-5461 and single-dose X-ray exposure were assessed using isobologram analysis using MTS assay and drug-induced cell death was assessed using flow cytometric, confocal microscopy and Western blot analysis.

Hadron production models' prediction for p distribution of charged hadrons in pp interactions at 7 TeV.

The yield of transverse momentum (p) spectra of integrated hadrons and their ratios produced in pp collisions at 7 TeV are reported using DPMJET-III, EPOS1.99, EPOS-LHC, HIJING1.383, QGSJETII-04, and Sibyll2.

Degradation of azo dyes by Alcaligenes aquatilis 3c and its potential use in the wastewater treatment.

In the present study, Alcaligenes aquatilis was found to decolorize 82% Synazol red 6HBN after incubation of 4 days at 37 °C and pH 7. Maximum decolorization was found under static conditions by using saw dust and yeast extract as carbon and nitrogen source. It also showed promising potential to decolorize mixture of multiple dyes at a rate of more than 86% in 5 days.

Phytochemical screening and antipyretic effects of hydroalcoholic extracts of selected medicinal plants of Rawalakot, Azad Jammu and Kashmir in albino rats.

Pyrexia occurs due to infection, malignancy and other diseases. Majority of the antipyretic drugs are synthetic in nature which exerts side effects such as gastric ulcer, hepatic necrosis and renal damage. The antipyretic potential of the hydro-alcoholic extracts of Achillea millefolium, Taraxacum officinale, Salix alba and Trigonella foenum were investigated on the yeast-induced pyrexia in albino rats.

Textural analysis and lung function study: Predicting lung fitness for radiotherapy from a CT scan.

Objective: This study tested the hypothesis that shows advanced image analysis can differentiate fit and unfit patients for radical radiotherapy from standard radiotherapy planning imaging, when compared to formal lung function tests, FEV1 (forced expiratory volume in 1 s) and TLCO (transfer factor of carbon monoxide).

Methods: An apical region of interest (ROI) of lung parenchyma was extracted from a standard radiotherapy planning CT scan. Software using a grey level co-occurrence matrix (GLCM) assigned an entropy score to each voxel, based on its similarity to the voxels around it.

Evaluation of Two Dosing Regimens for Nivolumab in Combination With Ipilimumab in Patients With Advanced Melanoma: Results From the Phase IIIb/IV CheckMate 511 Trial.

Purpose: Nivolumab 1 mg/kg plus ipilimumab 3 mg/kg (NIVO1+IPI3) is approved for first-line treatment of patients with advanced melanoma in several countries. We conducted a phase IIIb/IV study (CheckMate 511) to determine if nivolumab 3 mg/kg plus ipilimumab 1 mg/kg (NIVO3+IPI1) improves the safety profile of the combination.

Patients And Methods: Patients (N = 360) age 18 years or older with previously untreated, unresectable stage III or IV melanoma were randomly assigned 1:1 to NIVO3+IPI1 or NIVO1+IPI3 once every 3 weeks for four doses.

Industrially relevant cellulase production by indigenous thermophilic Bacillus licheniformis TLW-3 strain: Isolation-molecular identification and enzyme yield optimization.

Cellulases are the third largest single industrial bio-robots. These enzymes are employed in industries like pharmaceutical, textile, food processing, paper recycling and detergent manufacturing. In order to produce broadly diversified cellulases, microbes (both bacteria and fungi) have been exploited.

Biological effects of static magnetic field exposure in the context of MR-guided radiotherapy.

The clinical introduction of MRI-guided radiotherapy has prompted consideration of the potential impact of the static magnetic field on biological responses to radiation. This review provides an introduction to the mechanisms of biological interaction of radiation and magnetic fields individually, in addition to a description of the magnetic field effects on megavoltage photon beams at the macroscale, microscale and nanoscale arising from the Lorentz force on secondary charged particles. A relatively small number of scientific studies have measured the impact of combined static magnetic fields and ionising radiation on biological endpoints of relevance to radiotherapy.