Fabrication and characterization of natural fiber reinforced cowpea resin-based green composites: an approach towards agro-waste valorization.

A paradigm shift towards using bio-resins or bio-derived resins among materials scientists has led to wide exploration of the sector. Polymers such as soy protein isolate, poly(hydroxy alkanoate), poly(lactic acid), and thermoplastic starch are all synthetically modified bio-based resins and are costly. The cowpea-derived resin with the least chemical modification was used in this study as a matrix for the formation of composites with natural fibers at a lesser cost.

Poly Meta-Aminophenol (PmAP) as a Solid-State Electron Mediator in the Z-Scheme, AgPO/CoFeO Heterojunction: Mineralization of Highly Concentrated Bisphenol-A and Reactive Dyes Water Pollutants.

This study demonstrated the effectiveness of poly meta-aminophenol (PmAP) as a solid electron mediator in the Z-scheme photocatalytic system for organic pollutants (viz. bisphenol-A and reactive dyes) mineralization and also illustrated how PmAP transported the photogenerated electrons from an O-emitting photocatalyst (AgPO) to a H-emitting photocatalyst (CoFeO) enabling enhanced photocatalytic activity under visible light irradiation. The PmAP/AgPO-CoFeO (PAC-10), was prepared by a two-step process and characterized by various analytical methods to assess the impact of PmAP on optical, photocatalytic, and electrochemical characteristics of the CoFeO (CFO)/AgPO composite.

Bioinspired thiazolo-[2,3-b] quinazolin-6-one derivatives as potent anti-cancer agents targeting EGFR: their biological evaluations and in silico assessment.

Cancer is a challenging and second most deadly disease. The epidermal growth factor receptors (EGFRs) dimerize upon ligand bindings to the extracellular domain that intiates the downstream signaling cascades and activates intracellular kinase domain. Thus, activation of autophosphrylation through kinase domain results in metastasis, cell proliferation, and angiogenesis.

A new class of fluorogenic thiazolo[2,3-]quinazolinone receptor: selective detection towards mercury and hydrogen bisulfate ions in aqueous medium.

A series of fluorophoric and structurally diverse thiazoloquinazoline derivatives were synthesized in a one-pot multicomponent cascade reaction using a microwave irradiation technique. The unique structural arrangement of the synthesized compounds encouraged us to design a new type of bioactive molecular receptor. This receptor interacts with HSO in 1 : 1 and Hg in 1 : 2 binding stoichiometric ratios resulting in a change in fluorescence as well as absorption spectra in aqueous medium.

In Silico and In Vitro Evaluations of Fluorophoric Thiazolo-[2,3-b]quinazolinones as Anti-cancer Agents Targeting EGFR-TKD.

Epidermal growth factor receptor tyrosine kinase domain (EGFR-TKD) plays a pivotal role in cellular signaling, growth, and metabolism. The EGFR-TKD is highly expressed in cancer cells and was endorsed as a therapeutic target for cancer management to overcome metastasis, cell proliferation, and angiogenesis. The novel thiazolo-[2,3-b]quinazolinones series were strategically developed by microwave-assisted organic synthesis and multi dominos reactions aimed to identify the potent thiazolo-[2,3-b]quinazolinone inhibitor against EGFR-TKD.

Sustainable Process for the Extraction of Potassium from Feldspar Using Eggshell Powder.

To recover potassium from feldspar, a biowaste, i.e., eggshell, was used.

Resonance assignments and secondary structure prediction of secretory protein Rv0603 from Mycobacterium tuberculosis H37Rv.

We report the NMR resonance assignments of N-terminal signal sequence deleted secretory protein Rv0603 (∆-Rv0603) from Mycobacterium tuberculosis H37Rv. ∆-Rv0603 displayed good peak yield and signal dispersion in 2D [N-H] HSQC spectrum, which prompted us to proceed for resonance assignments on this construct. Standard triple-resonance experiments for resonance assignments were recorded on [U-N]-∆Rv0603 and [U-N, C]-∆Rv0603 samples.

The construction of fluorophoric thiazolo-[2,3-]quinazolinone derivatives: a multicomponent domino synthetic approach.

Acid-mediated one-pot domino reactions of substituted 2-amino thiazoles, substituted benzaldehydes and cyclic diketones have been developed for the synthesis of novel and architecturally unique thiazolo[2,3-]quinazolinone derivatives under microwave irradiation. In this protocol, a series of thiazolo[2,3-]quinazolinone derivatives have been synthesized and the excellent fluorescence behaviors of some of the molecules have been reported based on the incorporation of different electron-donating and electron-withdrawing substituents on the aryl moieties of the target molecules.

Growth-arresting Activity of Acmella Essential Oil and its Isolated Component D-Limonene (1, 8 P-Mentha Diene) against (Microbial Type Culture Collection 296).

Background: is used as a remedy in toothache complaints by the tribal people of Western part of Odisha, India.

Objective: The objective of this study was to study the growth-arresting activity of an indigenous Acmella essential oil (EO) ( Murr, ) and its isolated component, d-limonene against (microbial type culture collection 296).

Materials And Methods: The EO was extracted from flowers of indigenous using Clevenger's apparatus and analyzed by gas chromatography-mass spectrometry (GC-MS).

Design, synthesis and cytotoxicity of novel chalcone analogs derived from 1-cyclohexylpyrrolidin-2-one and 2,3-dihydrobenzo[f]chromen-1-one.

Two divergent series of novel chalcone analogs, one derived from 1-cyclohexylpyrrolidin-2-one and the other derived from 1-benzo[f]chromanone, were designed, synthesized and evaluated for cytotoxicity against two murine cancer cell lines. Two 1-benzo[f]chromanone analogs, 4g and 4j yielded moderate toxicity against both melanoma B16 and lymphoma L1210 cell lines with IC(50) values between the range of 5 and 6 µM. With an IC(50) value of 3.

5-Benzyl-idene-3-phenyl-2-phenyl-imino-1,3-thia-zolidin-4-one.

The title compound, C(22)H(16)N(2)OS, is a chalcone analog with a thia-zolidinone core that was synthesized as a potential cytotoxic and anti-cancer agent. The structure is commensurately modulated by unit-cell doubling along the direction of the a axis of the cell. The two crystallographically independent mol-ecules are differerentiated by the dihedral angle between the mean planes of the benzyl-idene phenyl group against the thia-zolidin-4-one moiety, which is 5.

Design, synthesis, and cytotoxicity of novel 3-arylidenones derived from alicyclic ketones.

Forty-four novel chalcone-inspired analogs having a 3-aryl-2-propenoyl moiety derived from alicyclic ketones were designed, synthesized, and investigated for cytotoxicity against murine B16 and L1210 cancer cell lines. The analogs belong to four structurally divergent series, three of which (series g, h, and i) contain differently substituted cyclopentanone units and the fourth (series j) contains a 3,3-dimethyl-4-piperidinone moiety. Of these, the analogs in series j showed potential cytotoxic activity against murine B16 (melanoma) and L1210 (lymphoma) cells.