CORRELATION OF LEPTIN AND ADIPONECTIN RECEPTOR EXPRESSION WITH CLINICOPATHOLOGICAL PARAMETERS IN COLORECTAL CARCINOMA - A CROSS-SECTIONAL PROSPECTIVE STUDY.

Background: Colorectal carcinoma (CRC) is one of the common carcinomas with a rising incidence of metastasis due to its advanced stage of presentation. The existing biomarkers such as CEA (Carcinoembryonic antigen) etc., for prognosis, have low sensitivity and specificity.

evaluation of the neuroprotective potential of against Aβ peptide-induced toxicity in human neuroblastoma SH-SY5Y cells.

Alzheimer's disease (AD) is a type of neurodegenerative disease, associated with the hastening of ROS, acetylcholinesterase (AChE) activity, and amyloid β peptides plaques in the brain. The limitations and side effects of existing synthetic drugs incline toward natural sources. In the present communication active principles of methanolic extract of Roxb, leaves are explored as an antioxidant, AChE inhibitor, and anti-amyloidogenic.

Ameliorative role of dietary acidifier potassium formate on growth metrics, blood chemistry, gut health and well-being indices of rohu, Labeo rohita fingerlings.

Organic acids and their derivatives have been attributed to growth and well-being improvement in fish when supplemented in their diets. Therefore, this study was conducted to evaluate the ameliorative role of potassium formate (PF) in rohu Labeo rohita fingerlings. A total of 240 healthy rohu fingerlings (9.

In Vivo Antitumor, Pharmacological and Toxicological Study of Pyrimido[ 4',5':4,5] thieno(2,3-b)quinoline with 9-hydroxy-4-(3-diethylaminopropylamino) and 8-methoxy-4-(3-diethylaminopropylamino) Substitutions.

Background: We previously synthesized two DNA intercalative Pyrimido[4',5':4,5]thieno(2,3-b) quinolines (PTQ), 9-hydroxy-4-(3-diethylaminopropylamino)pyrimido[4',5':4,5]thieno(2,3-b) quinolines (Hydroxy- DPTQ) and 8-methoxy-4-(3-diethylaminopropylamino) pyrimido[4',5':4,5]thieno(2,3-b) quinolines (Methoxy-DPTQ), and reported their cytotoxicity against cancer cell lines.

Methods: In the present study, we sought to analyze the antitumor activity of Hydroxy-DPTQ and Methoxy-DPTQ on Ehrlich's ascites carcinoma in vivo models, along with other pharmacological activities and toxicity.

Results: In this study, both the test molecules studied possess potent in vivo antitumor activity without any hematological, biochemical or nephrotoxicity.

Nano-selenium Supplementation to Ameliorate Nutrition Physiology, Immune Response, Antioxidant System and Disease Resistance Against Aeromonas hydrophila in Monosex Nile Tilapia (Oreochromis niloticus).

In the present work, a total 180 monosex male Nile tilapia fingerlings (15.73 ± 0.05 g) were stocked in 150-l FRP tanks categorised into four diet groups with triplicate each and fed with dietary nano-selenium-supplemented diets at different concentration (T1-0, T2-0.