Formulation and evaluation of solid lipid nanoparticles of a water soluble drug: Zidovudine.

The present investigation was undertaken to develop solid lipid nanoparticles (SLN) of a hydrophilic drug Zidovudine (an anti-human immunodeficiency viral agent) and improve the entrapment efficiency of the drug in SLN. The SLN were prepared with stearic acid by process of w/o/w double-emulsion solvent-evaporation method using 3(2) factorial design. Different triglycerides alone and in different combinations, with/without stearic acid were used to prepare SLN using similar procedure.